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Seamus O'Brien

@obriense.bsky.social
42 followers 44 following 65 posts

Antibiotic developer. Seabird lover, Arsenal, Rhinos, Leinster, Eagles, Celtics and RedSox, Film noir fan

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Reposted by Seamus O'Brien
Global Antibiotic R&D Partnership (GARDP) @gardp.bsky.social · 02/09/2026
📅 Save the date: 9–11 Feb 2027 The #ACC2027 is a free, open-access virtual conference, jointly organised by @bsacandjac.bsky.social and GARDP within the framework of the @eupohamr.bsky.social. More info coming soon! 🌐Explore the website: acc-conference.com
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Seamus O'Brien @obriense.bsky.social · 03/08/2026
Within lung transfer from other bacterial species. We are so up against it. Antibiotic resistance is such a challenge for the successful treatment of infections in CF patients #AMR
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Seamus O'Brien @obriense.bsky.social · 15/06/2026
"a victory for immigration" well said Emma Hayes. #CaboVerde #CapeVerde
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Reposted by Seamus O'Brien
Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 02/06/2026
🆕💥🔴Systematic review & meta-analysis of 8 RCTs (n=2,881) in HAP/VAP: ⏸️ Newer antibiotics offered no significant advantage over generic comparators for 28-day mortality, clinical response, or microbiological response. #idsky academic.oup.com/cid/article-...
academic.oup.com
Efficacy and Safety of Newer Antibiotics Versus Generic Antibiotics for Hospital-Acquired and Ventilator-Associated Bacterial Pneumonia: A Systematic Review and Meta-analysis of Randomized Controlled ...
Newer antibiotics, despite broader antimicrobial coverage, have not significantly outperformed generic comparators in terms of the 28-day all-cause mortali
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Reposted by Seamus O'Brien
arseblog @arseblog.com · 12/05/2026
"If you say it enough times, people will believe it whether it's true or not" – from Arsecast Extra 694 with @gunnerblog.bsky.social, out now in all the usual places
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Global Antibiotic R&D Partnership (GARDP) @gardp.bsky.social · 08/05/2026
Last week in Geneva, GARDP brought together 50+ partners in Geneva to help shape our 2027–2031 strategy. The consultation explored how we can strengthen collaboration, prioritize resources and maximize impact across AMR R&D and access. Thank you to all our partners for your presence and ideas.
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Reposted by Seamus O'Brien
Global Antibiotic R&D Partnership (GARDP) @gardp.bsky.social · 23/03/2026
📢 GARDP and Antabio partner to advance hit-to-lead antibiotic discovery. With few truly innovative drugs in the pipeline, advancing early research is key to tackling drug-resistant infections. 🔗 Read more: gardp.pulse.ly/ghuis8ftsg
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Reposted by Seamus O'Brien
Global Antibiotic R&D Partnership (GARDP) @gardp.bsky.social · 14/03/2026
📊 A new paper in ACS Infectious Diseases discusses AntibioticDB - the only open-access database of antibacterial agents supporting antibacterial R&D. 💻🔬 Now with new Chemical Structure search function. 📖 acs.pulse.ly/f1zx92bgc8 🔎 antibioticdb.pulse.ly/oynhhtpj6k
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Reposted by Seamus O'Brien
Global Antibiotic R&D Partnership (GARDP) @gardp.bsky.social · 23/11/2025
📊 2025 progress in GARDP’s DER programme 🤝Partnered with the Institute of Science Tokyo to explore protein-compound structures, aiming to develop new antibiotics for drug-resistant infections. 🔎Shared new DER research at global meetings. 🔗https://bit.pulse.ly/sp5uubtrqa #WAAW2025
bit.pulse.ly
Discovery & exploratory research | GARDP
Growing drug resistance is outpacing the development of antibiotics for the most difficult-to-treat infections. Producing such antibiotics starts with the earli
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Reposted by Seamus O'Brien
Arsenal FC @arsenalfc.bsky.social · 23/11/2025
STATEMENT MADE.
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Reposted by Seamus O'Brien
Global Antibiotic R&D Partnership (GARDP) @gardp.bsky.social · 19/11/2025
Gonorrhoea accounts for over 82 million new cases each year and has had no new treatment in more than 40 years. GARDP and Innoviva Specialty Therapeutics have co-developed zoliflodacin, an investigational first-in-class oral antibiotic now under FDA review. THIS IS BIG. #WAAW2025 #AMR
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Reposted by Seamus O'Brien
LifeArc @lifearc.bsky.social · 11/11/2025
If you weren't able to attend #GAMRIC2025, or you want to catch up on sessions you missed, a comprehensive round-up is now live, covering each session of the conference in detail ➡️ www.gamric.org/about-gamric/confere… @carb-x.bsky.social @escmid.bsky.social @gardp.bsky.social
gamric.org
Conference round-up
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Reposted by Seamus O'Brien
Nature Microbiology @natmicrobiol.nature.com · 15/10/2025
A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics By Kuan-Yi Lu, Brian Conlon & colleagues. #microsky www.nature.com/articles/s41...
nature.com
A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics - Nature Microbiology
The authors developed a screen to find compounds that modulate intracellular Staphylococcus aureus metabolism and discovered KL1, which sensitizes persisters to antibiotics by reversing host-induced t...
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Reposted by Seamus O'Brien
Global Antibiotic R&D Partnership (GARDP) @gardp.bsky.social · 17/09/2025
GARDP’s Executive Director Dr Manica Balasegaram writes about the urgent need to revive antibiotic R&D in the Financial Times. Without it, patients may survive cancer, only to lose their lives from untreatable infections. 📖 Read the op-ed here (subscriber-only): www.ft.com/content/196f...
ft.com
Antibiotic resistance is the greatest threat to cancer patients
Investing in new oncology drugs without building up an effective arsenal against infections is a false economy
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Reposted by Seamus O'Brien
Global Antibiotic R&D Partnership (GARDP) @gardp.bsky.social · 13/09/2025
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Reposted by Seamus O'Brien
Global Antibiotic R&D Partnership (GARDP) @gardp.bsky.social · 13/09/2025
Every 2.8 seconds, someone dies of sepsis. That’s 1 in 5 deaths worldwide. This #WorldSepsisDay, we share 5 key facts about sepsis and 5 actions GARDP is taking with partners worldwide to fight it. 👉 Swipe through. Share it with your network. #Sepsis #AMR #GARDP
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Seamus O'Brien @obriense.bsky.social · 25/07/2025
Incredible interview on @bbcradio4 Today programme. Great credit to Nick Robinson for standing up for his and BBC's credibility and independent journalism in the face of a bully representing a desperate and brutal Israel state #BBCR4 #aidnow #stopthefamine #gaza
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Reposted by Seamus O'Brien
Global Antibiotic R&D Partnership (GARDP) @gardp.bsky.social · 25/07/2025
📰 The Nikkan Kogyo Shimbun covers GARDP’s new joint research with Institute of Science Tokyo on developing novel antibiotics to address drug-resistant infections. Read the story here : www.nikkan.co.jp/articles/vie...
nikkan.co.jp
東京科学大とGARDP、抗菌薬を共同研究
東京科学大学とグローバル抗菌薬研究開発パートナーシップ(GARDP)は、新しい抗菌薬の開発に向けた共同研究契約を締結した。......
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Reposted by Seamus O'Brien
Global Antibiotic R&D Partnership (GARDP) @gardp.bsky.social · 14/06/2025
Big thanks to the experts at our #AMR workshop during ReAct Africa Network in Lusaka—working to prioritize key antibiotics for treating childhood sepsis in Sub-Saharan Africa. 💊🌍 #Sepsis #ChildHealth #GARDP
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Global Antibiotic R&D Partnership (GARDP) @gardp.bsky.social · 14/05/2025
Join Dr Steven Tong & Dr Patrick Harris to delve into how post-licensing clinical trials help us use antibiotics more effectively. 🗓️ 22 May 2025 | ⏰ 09:30–11:00 CEST 💬 Live Q&A included 🔗 Register now: tinyurl.com/2kr3cbym #REVIVE #ClinicalTrials #InfectiousDiseases #REVIVEWebinar #GARDP
Join Dr Steven Tong & Dr Patrick Harris to delve into how post-licensing clinical trials help us use antibiotics more effectively.

🗓️ 22 May 2025 | ⏰ 09:30–11:00 CEST

💬 Live Q&A included

🔗 Register now: https://tinyurl.com/2kr3cbym

#REVIVE #ClinicalTrials #InfectiousDiseases #REVIVEWebinar #GARDP
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Seamus O'Brien @obriense.bsky.social · 10/05/2025
Lovely day at Emirates. Excellent game, credit to both teams but great for us to close the WSL in style. On to Lisbon #Arsenal #WSL
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Reposted by Seamus O'Brien
Nature Microbiology @natmicrobiol.nature.com · 09/05/2025
🚨Out now! A new study that shows that typhoid toxin disrupts the blood–brain barrier leading to vascular leakage, inflammation and neurological symptoms, causing encephalopathy in typhoid fever. Corticosteroids help mitigate these effects. #MicroSky www.nature.com/articles/s41...
nature.com
Typhoid toxin causes neuropathology by disrupting the blood–brain barrier - Nature Microbiology
This study shows that typhoid toxin disrupts the blood–brain barrier leading to vascular leakage, inflammation and neurological symptoms, causing encephalopathy in typhoid fever. Corticosteroids help ...
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Reposted by Seamus O'Brien
Global Antibiotic R&D Partnership (GARDP) @gardp.bsky.social · 02/05/2025
Great discussions this morning at the Indo-Swiss AMR Innovation Dialogue in partnership with Swissnex Valuable exchange with partners and experts from India on strengthening innovation and collaboration to tackle drug-resistant infections. 🤝💡 #AMR #Innovation #India #Switzerland #Partnerships #R&D
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Seamus O'Brien @obriense.bsky.social · 02/05/2025
Important modelling data from our access team @gardp.bsky.social antibiotics that can be used optimally to address difficult to treat resistant infections are not available where they are needed the most #AMR #Antibiotics #GlobalHealth
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Reposted by Seamus O'Brien
Global Antibiotic R&D Partnership (GARDP) @gardp.bsky.social · 01/05/2025
🚨 This is Big! New GARDP research shows that people with multidrug-resistant infections in LMICs are not receiving the appropriate antibiotics because of large gaps in access. Improving access and developing new antibiotics must be a priority, 📖 Read the study www.thelancet.com/journals/lan...
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Seamus O'Brien @obriense.bsky.social · 19/04/2025
@markradcliffe.bsky.social green Isaac for the green, come on. Am I taking this too seriously
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Reposted by Seamus O'Brien
Ulf R. Dahle @ulfdahle.bsky.social · 16/04/2025
WHO Member States have finalized a draft Pandemic Agreement to strengthen global pandemic prevention and response. It includes commitments to equity, a #OneHealth approach, and respecting national sovereignty. Proposal will be considered at World Health Assembly in May. www.who.int/news/item/16...
who.int
WHO Member States conclude negotiations and make significant progress on draft pandemic agreement
After more than three years of intensive negotiations, WHO Member States took a major step forward in efforts to make the world safer from pandemics, by forging a draft agreement for consideration at ...
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Seamus O'Brien @obriense.bsky.social · 10/03/2025
Thinking of all the staff at the wonderful RSPB Bempton Cliffs and the concern for the seabird breeding habitat with the potential oil spill of the East Yorks coast #RSPB #EastYorks #NorthSea #Tankercrash
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Seamus O'Brien @obriense.bsky.social · 26/01/2025
Fly Eagles Fly #NFCChampions
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Seamus O'Brien @obriense.bsky.social · 04/01/2025
When are the sports media going to really start questioning Ange Postecoglu. He is getting away with it, a shocking set of results, #Spurs #Ange
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Seamus O'Brien @obriense.bsky.social · 09/10/2024
Eidevall out now #ArsenalWomen
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