iiinova — where your digital self keeps evolving

Omar Saleh @oasaleh.bsky.social · 19/02/2026

Yes! Various theory papers about this. The nanostar system is well suited to explore programmed crosstalk…. Funding willing, we might explore this

100 1

Omar Saleh @oasaleh.bsky.social · 19/02/2026

Yes we could, but not in this study where we engineered things to have as little crosstalk as possible. We checked and the Tm of a given phase is about the same regardless of the presence of the other eight phases. We argue in the paper that this ‘zero crosstalk’ limit is easier to achieve with DNA

100 1

Omar Saleh @oasaleh.bsky.social · 18/02/2026

…we further show that appropriate thermal processing lead to metastable jammed-droplet layers, which are kinetically stabilized by cages formed from the diverse immiscible phases… so new types of structure and dynamics are possible with this system (2/3)

150 5

Omar Saleh @oasaleh.bsky.social · 18/02/2026

New from us in @pnas.org : We considered the limits of condensate diversity, and engineered DNA droplets to form 9 distinct, homotypic, coexisting phases. Very hard to do this except with nucleic acids. Probably you can make more than 9. (1/3)

32810 28

Omar Saleh @oasaleh.bsky.social · 11/02/2026

Sorry! Please feel free to return to your regularly scheduled doom scrolling.

000 0

Omar Saleh @oasaleh.bsky.social · 11/02/2026

… With enzymatic degradation, a curious behavior in which droplets disappear while their avg radius stays constant (red images). Lovely work by post doc fellow Michio Tateno. Check out the paper at the link. doi.org/10.1103/x2pf...

doi.org

Diffusive and Enzymatic Modulation of the Dynamic Size Distribution of DNA Droplets

An experimental model system of DNA nanoparticles shows that the droplet size distribution can be controlled by the droplets' phase separation ability.

010 1

Omar Saleh @oasaleh.bsky.social · 11/02/2026

New paper from us in PRL: Precision measurements of DNA condensate droplets as modulated by diffusive (Ostwald) or enzymatic processes. We verify LSW models of Ostwald ripening at the level of single droplets (blue images), and observe dynamic scaling of the size distribution….

360 6

Omar Saleh @oasaleh.bsky.social · 29/11/2025

I am not sure it is a major conflict. The poster is correct that the scaffold concept has been taken too far in certain cases. But he is not questioning the entire condensate/LLPS field; to the contrary he praises certain approaches

050 5

Omar Saleh @oasaleh.bsky.social · 21/11/2025

Check out our paper on transcriptional control of an artificial condensate, including engineering a feedback loop that includes phase separation. Led by the amazing @samwilken.bsky.social

151 5

Omar Saleh @oasaleh.bsky.social · 01/09/2025

PRX Life seems like a good choice, though maybe you are thinking to aim higher? It is a great result

100 1

Reposted by Omar Saleh

University of California @uofcalifornia.bsky.social · 09/08/2025

“As a public university, we are stewards of taxpayer resources, and a payment of this scale would completely devastate our country’s greatest public university system as well as inflict great harm on our students and all Californians.” —UC President James B. Milliken

78821332 821

Omar Saleh @oasaleh.bsky.social · 16/07/2025

Best time to come is the winter, for the obvious reason (maximal weather difference between Canada and here) but also because it is the clearest time, and you get great views of the islands from that particular room

010 1

Omar Saleh @oasaleh.bsky.social · 10/05/2025

Maybe the new NSF will fund this Seems like the kind of thing the administration will like

010 1

Omar Saleh @oasaleh.bsky.social · 10/05/2025

How many of you are there

100 1

Omar Saleh @oasaleh.bsky.social · 09/05/2025

Hey this looks fun Congrats!

100 1

Omar Saleh @oasaleh.bsky.social · 27/04/2025

No I believe research gov went down and came back up without any issues or changes This whole thing was strange from the start; we have all sorts of email trails and office of research paperwork on awards, right?

research.gov

Research.gov - Homepage

Research.gov is a partnership of Federal, research-oriented grant making agencies with a shared vision of increasing customer service for applicants while streamlining and standardizing processes amon...

100 1

Reposted by Omar Saleh

Jerelle Joseph @jerelleaj.bsky.social · 12/03/2025

This summer in beautiful Santa Barbara we will run a 3-day conference on “Biological Physics of Biomolecular Condensates: Bridging Theory and Experiment” June 16 to 18th. Register now: www.kitp.ucsb.edu/activities/b...

02012 20

Omar Saleh @oasaleh.bsky.social · 21/03/2025

APSMarch attendees: eat to bed early so you can get to the 8am session on Friday: Bioinspired phase separation, wi the Lorenzo Di Michele and many other great speakers. 8am sharp in the Hilton 4th floor Palos Verdes room summit.aps.org/events/MAR-W64

summit.aps.org

Bioinspired Phase Separation

8:00 am – 10:48 am, Friday March 21, Session MAR-W64, Anaheim Hilton, Palo Verdes (Level 4)

072 7

Omar Saleh @oasaleh.bsky.social · 14/03/2025

Note excellent invited speakers on both days starting at 8am sharp!

010 1

Omar Saleh @oasaleh.bsky.social · 14/03/2025

For those condensate and active fluid fans attending the APS meeting next week, please wake up early and come to our 8am sessions on Thursday and Friday, co organized by myself, Ahmad Omar, Lauren Zarzar, and Sam Wilken Details here: summit.aps.org/events/MAR-Q64 summit.aps.org/events/MAR-W64

summit.aps.org

Multi-Component Active Liquids

8:00 am – 11:00 am, Thursday March 20, Session MAR-Q64, Anaheim Hilton, Palo Verdes (Level 4)

150 5

Omar Saleh @oasaleh.bsky.social · 25/02/2025

Yeah I saw this also… was hoping to get to LA from Santa Barbara; getting to Sacramento is a bit harder

010 1

Omar Saleh @oasaleh.bsky.social · 20/02/2025

Yeah I read this yesterday… a sad ending to an article that, in the first place, was discussing intrinsic issues with the university funding model. May we be so lucky to just have those intrinsic issues in a year

010 1

Omar Saleh @oasaleh.bsky.social · 13/02/2025

No despairing!! Fight fight fight

100 1

Omar Saleh @oasaleh.bsky.social · 10/02/2025

the wide scale legal action about the NIH IDC is great. I am concerned that there is no such action for the NSF. basic research generates long term technological/economic benefit, but the long time scale makes it vulnerable to short term budget thinking Who is championing the NSF?

052 5

Omar Saleh @oasaleh.bsky.social · 09/02/2025

Well all the more reason to take quick action then!

100 1

Omar Saleh @oasaleh.bsky.social · 09/02/2025

Though even CRISPR was at least 15 years, and perhaps longer depending on which fundamental research paper you want to start counting from

000 0

Omar Saleh @oasaleh.bsky.social · 09/02/2025

You are right It probably varies with sector. Some physics things are longer scale Agreed that biotech is much faster

100 1

Omar Saleh @oasaleh.bsky.social · 09/02/2025

Me too! I am literally waking up in the middle of the night with this crap running through my head Private industry generally no longer carries out research …bell labs is long gone…but in pharma they still do some

000 0

Omar Saleh @oasaleh.bsky.social · 09/02/2025

Is your comment about the real world or online discourse? I think in the real world there are a lot of powerful entities (companies) that rely on an educated workforce. Even Musk seemed to acknowledge this in the H1B visa discussion last fall

100 1

Omar Saleh @oasaleh.bsky.social · 09/02/2025

My worry with that approach (focusing on scientific areas with such direct and ongoing applications) is that the argument does not protect fundamental research (NSF, and a lot of the NIH and DOE)

100 1

Omar Saleh @oasaleh.bsky.social · 09/02/2025

Yeah, agreed about the delay…stopping research will tank the economy in 30-50 years, not right away. A teaching strike is pretty immediate. This is a huge benefit when the NIH order takes effect tomorrow. No retailer/company will stop selling Viagra because we ask (why did you choose viagra?)

200 2

Omar Saleh @oasaleh.bsky.social · 09/02/2025

Well we might be forced to stop doing research anyway, regardless of what I choose. Maybe the ‘deal’ I outlined is simplistic. But teaching is the only mechanism of civil disobedience we really have, right?

100 1

Omar Saleh @oasaleh.bsky.social · 09/02/2025

A teaching/grading strike would put pressure on the universities, and students and their families; this pressure might then transfer upwards to elected officials. I don’t like pressuring students, but I also don’t see what other levers I have apart from teaching.

010 1

Omar Saleh @oasaleh.bsky.social · 09/02/2025

My understanding of my job: I garner federal funding to carry out research, in part to support the economy and security of the nation. In return for the opportunity to do this, I teach. Friday’s NSF budget proposal, and NIH budget cut, breaks this deal. Ergo, shouldn’t I stop teaching?

260 6

Omar Saleh @oasaleh.bsky.social · 22/11/2024

Thanks for doing this! Can I be added?

110 1

Omar Saleh @oasaleh.bsky.social · 14/11/2024

Thanks for making this! I also would appreciate being added

010 1