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Nuno Valente-Leal

@nunovalenteleal.bsky.social
125 followers 478 following 13 posts

a former microbiologist in the realm of metabolism and female fertility 🪰 🔬 PhD Student- Carvalho-Santos Lab - GIMM🧑‍🔬 he/his/him

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Reposted by Nuno Valente-Leal
Nobel Prize @nobelprize.org · 05/10/2026
This year’s medicine laureate Karl Deisseroth transformed the protein channelrhodopsin into a light-controlled switch for nerve cells. Deisseroth introduced the gene for channelrhodopsin into nerve cells from rats. By illuminating the cells with blue light, he was able to trigger a nerve signal.
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Reposted by Nuno Valente-Leal
Arjuna Rajakumar PhD @arjunarajakumar.bsky.social · 19/09/2026
So proud of my lab mate @sagrill.bsky.social (whose on the job market 👀) for this magnum opus from @remlehmann.bsky.social lab @whiteheadinstitute.bsky.social ScRNA-seq of 🪰 germ cells reveals new biology, answers age old questions, and proposes new paradigms! 1/8 www.biorxiv.org/content/10.6...
Drosophila stage 10b embryo w/HCR staining marking two germ cell clusters. One will successfully colonize the gonad and the other, like tears in the rain, will be lost forever
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Reposted by Nuno Valente-Leal
Zita Carvalho-Santos Lab @zsantoslab.bsky.social · 16/09/2026
Last week, our amazing Patrícia Francisco represented the lab at #NeuroFly2026 in Cologne, presenting our latest work: "Ovary-derived signals align protein appetite with oogenesis." (if you're curious, take a look: www.biorxiv.org/content/10.6...) It was a great week, with great talks and people.
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Reposted by Nuno Valente-Leal
Yichen Luo 骆奕辰 @camellyc.bsky.social · 03/08/2026
1/8 Breathing seems automatic. But it's a finely tuned motor behavior that has to be controlled. In this preprint, I map the circuits that match a fly's respiration to the metabolic demands of flight and mitigate the risk of dehydration. 🧵🪰 www.biorxiv.org/content/10.6...
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Reposted by Nuno Valente-Leal
Shefali @iamshef.bsky.social · 10/07/2026
#NewPreprint Alert 📢📢📢 Check out our work showing #Drosophila #Ldh deficiency leads to impaired larval mobility. This started as a simple question of why Ldh mutants exhibit diet dependent lethality.🧵 #genetics #metabolism @iubiology.bsky.social @superflymr.bsky.social @tennessenlab.bsky.social
biorxiv.org
Drosophila melanogaster lactate dehydrogenase deficiency recapitulates the exercise intolerance of human glycogen storage disease type XI
Lactate dehydrogenase A (LDHA) is a key glycolytic enzyme that commonly exhibits altered expression in human diseases such as cancers and neurodegeneration, making it a valuable disease biomarker and ...
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Reposted by Nuno Valente-Leal
Zita Carvalho-Santos Lab @zsantoslab.bsky.social · 08/07/2026
Thrilled to share that Zita @carvalhosantosz.bsky.social has been selected as a FENS-Kavli Scholar, representing 🇵🇹 in the FENS-Kavli Network of Excellence! During the next 4 years she will join a group of 30 scientists to shape the future of neuroscience through collaboration and discovery!
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Reposted by Nuno Valente-Leal
Irene Miguel-Aliaga @irenemiguel-aliaga.bsky.social · 30/06/2026
Lab's latest: sculpting sex-biased metabolic territories in the intestine by tuning ploidy and lipid metabolism. Myc is to blame; Laura, Pedro and Chris found out www.cell.com/developmenta...
cell.com
Myc sustains sex-biased organ zonation in the Drosophila intestine
Amourda, Blackie, Gaspar, et al. show that sex-biased activity of Dsx and Myc shapes intestinal zonation and lipid metabolism in Drosophila. Elevated Myc activity in female enterocytes increases ploid...
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Reposted by Nuno Valente-Leal
Zita Carvalho-Santos Lab @zsantoslab.bsky.social · 13/05/2026
The 1st Metabolism & Physiology Day took place at @gimminstitute.bsky.social . It was a day full of engaging discussions and scientific exchange within the community, sparking new ideas and potential collaborations. We would like to thank Sara Violante, for the amazing expert talk. 🧵
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Nuno Valente-Leal @nunovalenteleal.bsky.social · 13/05/2026
🏆 best poster presentation 🏆 Thank you to the organising team of this event! It was a full day of amazing science! I hope this becomes a long lasting tradition at our institute!
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Reposted by Nuno Valente-Leal
Junior European Drosophila Investigators @fly-jedi.bsky.social · 12/05/2026
Amazing news! The company of biologists @biologists.bsky.social has decided to support our upcoming meeting! We now only have a couple of spots left for the upcoming JEDI #Drosophila meeting. 📍Palmela, Portugal 📅 June 1st to 3rd Register: congressos.mundiconvenius.pt/geral/inseri...
congressos.mundiconvenius.pt
New registration
New registration
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Reposted by Nuno Valente-Leal
Metabolism in Development and Physiology, Virtual Seminar Series @devmetphys.bsky.social · 12/05/2026
Join us this week for the next Zoom meeting on Metabolism in Development! Thursday, May 14th 2026, 4pm CET Qun-Ying Lei (Fudan University Shanghai Medical College) Meng Zhu (Harvard Medical School) Zoom link: vbc-ac-at.zoom.us/j/6417065777...
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Reposted by Nuno Valente-Leal
MC Gambetta @mcgambetta.bsky.social · 04/05/2026
Hello all, our lab is recruiting a PhD candidate to study how 3D genome folding impacts gene regulation in development. We're located at the Center for Integrative Genomics department of the University of Lausanne, Switzerland. Please email me if interested. #PhDPosition, #PhDOpportunity
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Nuno Valente-Leal @nunovalenteleal.bsky.social · 28/04/2026
My first one 🥹🥹! In this Perspective, we highlight the power of combining Drosophila genetics with metabolic sensors to better understand how metabolism shapes physiology, inspired by the amazing work from the Schirmeier Lab. Curious about our pov? Take a look!
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Reposted by Nuno Valente-Leal
Zita Carvalho-Santos Lab @zsantoslab.bsky.social · 27/04/2026
‼️ GENTLE REMINDER ‼️
Only 1 week left to register! Don’t miss this opportunity to come together and discuss the hottest topics in Drosophila research! Join us in Pamela to enjoy great science, sun, and of course… pastéis de nata! We can’t wait to see you there!
fly-jedi.org
Junior European Drosophila Investigators | JEDI Meeting 2026 | Palmela, Portugal
JEDI Meeting 2026 in Portugal 🇵🇹 - June 1–3, 2026
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Reposted by Nuno Valente-Leal
Zita Carvalho-Santos Lab @zsantoslab.bsky.social · 08/04/2026
What is our research focus? The answer captured in a single picture by Quirky Luísa (ig: quirky.luisa)
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Reposted by Nuno Valente-Leal
Zita Carvalho-Santos Lab @zsantoslab.bsky.social · 10/04/2026
Zita’s Keynote Speaker Debut! 
Huge thanks to the @drosospain.bsky.social organisers for the invitation!
It has been a blast hearing about all the fantastic work our neighbours are doing!!!
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Reposted by Nuno Valente-Leal
Juan C. Landoni @jclandoni.bsky.social · 03/04/2026
Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]
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Reposted by Nuno Valente-Leal
Katja Rust @rustflylab.bsky.social · 25/03/2026
Our paper is now available as early access at Nature Communications! Using the #Drosophila follicle epithelium as a model, we applied #scRNAseq, #LiveImaging, and cell biological tools to unravel functions of aberrant EGFR-Ras and Hedgehog signaling. www.nature.com/articles/s41...
nature.com
Hh and EGFR-Ras signaling promote distinct steps of tumor progression in the Drosophila follicle epithelium - Nature Communications
Aberrant signaling pathway activation is a key driver of tumorigenesis. Using single-cell RNA sequencing, the authors unravel how EGFR-Ras and Hedgehog signaling promote distinct steps of tumor progre...
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Nuno Valente-Leal @nunovalenteleal.bsky.social · 25/03/2026
The first preprint of the @zsantoslab.bsky.social has arrived!!! Ovaries control protein appetite - what about that? Are you curious to know how? Take a look below! Also, if you want to laugh a bit check the thread 🧵
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Nuno Valente-Leal @nunovalenteleal.bsky.social · 13/03/2026
‼️‼️ If you are interest on how Drosophila melanogaster integrates internal signals and environmental cues to regulate reproduction take a look at this book chapter! #fruitfly #drosophila #oogenesis
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Nuno Valente-Leal @nunovalenteleal.bsky.social · 04/02/2026
Last week, I had the pleasure of attending the 1st CAML&GIMM PhD meeting! I’m especially glad to have been part of the organizing team! Thank you to this amazing committee and everyone that contributed to making this meeting a success! See you again next year!
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Nuno Valente-Leal @nunovalenteleal.bsky.social · 17/12/2025
new lab, new blessings #fruitfly #drosophila #PhDlife
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Nuno Valente-Leal @nunovalenteleal.bsky.social · 21/11/2025
Just culturing Drosophila ovaries ex-vivo🪰! #Drosophila #fruitfly #PhDlife
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Nuno Valente-Leal @nunovalenteleal.bsky.social · 11/11/2025
Took the stage at the XI Portuguese Drosophila Research Meeting to discuss science, flies, and the alarming number of hours I spend counting eggs! Grateful for the discussions and the community! #drosophilaresearch #metabolism #drosophila #fruitfly
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Alex Gould Lab @alexgouldlab.bsky.social · 04/02/2025
Our latest... Congrats to Seb Sorge, Victor Girard & coauthors for devising HolFast, a chemically defined (holidic) diet for #Drosophila development that performs almost as well as a yeast diet. If you study developmental #nutrition or #metabolism please try it out... www.cell.com/developmenta...
HolFast is a new chemically defined (holidic) diet for Drosophila development that performs almost as well as a yeast diet.
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Reposted by Nuno Valente-Leal
Andy Fraser @andyfraser.bsky.social · 04/02/2025
Delighted to share our latest paper describing a method to read the levels of hundreds of metabolites or drugs in parallel using DNA sequencing. This method, which we call ‘smol-seq’ (Small MOLecule sequencing), harnesses the power of DNA sequencing for metabolite detection: rdcu.be/d8xLv (1/6)
rdcu.be
Quantifying metabolites using structure-switching aptamers coupled to DNA sequencing
Nature Biotechnology - Metabolites can be quantified using a combination of aptamers and DNA barcodes.
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