Reposted by Nuno Valente-LealNobel Prize @nobelprize.org · 05/10/2026This year’s medicine laureate Karl Deisseroth transformed the protein channelrhodopsin into a light-controlled switch for nerve cells. Deisseroth introduced the gene for channelrhodopsin into nerve cells from rats. By illuminating the cells with blue light, he was able to trigger a nerve signal. 114433
Reposted by Nuno Valente-LealArjuna Rajakumar PhD @arjunarajakumar.bsky.social · 19/09/2026So proud of my lab mate @sagrill.bsky.social (whose on the job market 👀) for this magnum opus from @remlehmann.bsky.social lab @whiteheadinstitute.bsky.social ScRNA-seq of 🪰 germ cells reveals new biology, answers age old questions, and proposes new paradigms! 1/8 www.biorxiv.org/content/10.6... 36028
Reposted by Nuno Valente-LealZita Carvalho-Santos Lab @zsantoslab.bsky.social · 16/09/2026Last week, our amazing Patrícia Francisco represented the lab at #NeuroFly2026 in Cologne, presenting our latest work: "Ovary-derived signals align protein appetite with oogenesis." (if you're curious, take a look: www.biorxiv.org/content/10.6...) It was a great week, with great talks and people. 093
Reposted by Nuno Valente-LealYichen Luo 骆奕辰 @camellyc.bsky.social · 03/08/20261/8 Breathing seems automatic. But it's a finely tuned motor behavior that has to be controlled. In this preprint, I map the circuits that match a fly's respiration to the metabolic demands of flight and mitigate the risk of dehydration. 🧵🪰 www.biorxiv.org/content/10.6... 411943
Reposted by Nuno Valente-LealShefali @iamshef.bsky.social · 10/07/2026#NewPreprint Alert 📢📢📢 Check out our work showing #Drosophila #Ldh deficiency leads to impaired larval mobility. This started as a simple question of why Ldh mutants exhibit diet dependent lethality.🧵 #genetics #metabolism @iubiology.bsky.social @superflymr.bsky.social @tennessenlab.bsky.socialbiorxiv.orgDrosophila melanogaster lactate dehydrogenase deficiency recapitulates the exercise intolerance of human glycogen storage disease type XILactate dehydrogenase A (LDHA) is a key glycolytic enzyme that commonly exhibits altered expression in human diseases such as cancers and neurodegeneration, making it a valuable disease biomarker and ... 3195
Reposted by Nuno Valente-LealZita Carvalho-Santos Lab @zsantoslab.bsky.social · 08/07/2026Thrilled to share that Zita @carvalhosantosz.bsky.social has been selected as a FENS-Kavli Scholar, representing 🇵🇹 in the FENS-Kavli Network of Excellence! During the next 4 years she will join a group of 30 scientists to shape the future of neuroscience through collaboration and discovery! 053
Reposted by Nuno Valente-LealIrene Miguel-Aliaga @irenemiguel-aliaga.bsky.social · 30/06/2026Lab's latest: sculpting sex-biased metabolic territories in the intestine by tuning ploidy and lipid metabolism. Myc is to blame; Laura, Pedro and Chris found out www.cell.com/developmenta...cell.comMyc sustains sex-biased organ zonation in the Drosophila intestineAmourda, Blackie, Gaspar, et al. show that sex-biased activity of Dsx and Myc shapes intestinal zonation and lipid metabolism in Drosophila. Elevated Myc activity in female enterocytes increases ploid... 23210
Reposted by Nuno Valente-LealZita Carvalho-Santos Lab @zsantoslab.bsky.social · 13/05/2026The 1st Metabolism & Physiology Day took place at @gimminstitute.bsky.social . It was a day full of engaging discussions and scientific exchange within the community, sparking new ideas and potential collaborations. We would like to thank Sara Violante, for the amazing expert talk. 🧵 141
Nuno Valente-Leal @nunovalenteleal.bsky.social · 13/05/2026🏆 best poster presentation 🏆 Thank you to the organising team of this event! It was a full day of amazing science! I hope this becomes a long lasting tradition at our institute! 000
Reposted by Nuno Valente-LealJunior European Drosophila Investigators @fly-jedi.bsky.social · 12/05/2026Amazing news! The company of biologists @biologists.bsky.social has decided to support our upcoming meeting! We now only have a couple of spots left for the upcoming JEDI #Drosophila meeting. 📍Palmela, Portugal 📅 June 1st to 3rd Register: congressos.mundiconvenius.pt/geral/inseri...congressos.mundiconvenius.ptNew registrationNew registration 0249
Reposted by Nuno Valente-LealMetabolism in Development and Physiology, Virtual Seminar Series @devmetphys.bsky.social · 12/05/2026Join us this week for the next Zoom meeting on Metabolism in Development! Thursday, May 14th 2026, 4pm CET Qun-Ying Lei (Fudan University Shanghai Medical College) Meng Zhu (Harvard Medical School) Zoom link: vbc-ac-at.zoom.us/j/6417065777... 141
Reposted by Nuno Valente-LealMC Gambetta @mcgambetta.bsky.social · 04/05/2026Hello all, our lab is recruiting a PhD candidate to study how 3D genome folding impacts gene regulation in development. We're located at the Center for Integrative Genomics department of the University of Lausanne, Switzerland. Please email me if interested. #PhDPosition, #PhDOpportunity 05844
Nuno Valente-Leal @nunovalenteleal.bsky.social · 28/04/2026My first one 🥹🥹! In this Perspective, we highlight the power of combining Drosophila genetics with metabolic sensors to better understand how metabolism shapes physiology, inspired by the amazing work from the Schirmeier Lab. Curious about our pov? Take a look! 000
Reposted by Nuno Valente-LealZita Carvalho-Santos Lab @zsantoslab.bsky.social · 27/04/2026‼️ GENTLE REMINDER ‼️ Only 1 week left to register! Don’t miss this opportunity to come together and discuss the hottest topics in Drosophila research! Join us in Pamela to enjoy great science, sun, and of course… pastéis de nata! We can’t wait to see you there!fly-jedi.orgJunior European Drosophila Investigators | JEDI Meeting 2026 | Palmela, PortugalJEDI Meeting 2026 in Portugal 🇵🇹 - June 1–3, 2026 034
Reposted by Nuno Valente-LealZita Carvalho-Santos Lab @zsantoslab.bsky.social · 08/04/2026What is our research focus? The answer captured in a single picture by Quirky Luísa (ig: quirky.luisa) 062
Reposted by Nuno Valente-LealZita Carvalho-Santos Lab @zsantoslab.bsky.social · 10/04/2026Zita’s Keynote Speaker Debut! Huge thanks to the @drosospain.bsky.social organisers for the invitation! It has been a blast hearing about all the fantastic work our neighbours are doing!!! 0103
Reposted by Nuno Valente-LealJuan C. Landoni @jclandoni.bsky.social · 03/04/2026Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6] 317665
Reposted by Nuno Valente-LealKatja Rust @rustflylab.bsky.social · 25/03/2026Our paper is now available as early access at Nature Communications! Using the #Drosophila follicle epithelium as a model, we applied #scRNAseq, #LiveImaging, and cell biological tools to unravel functions of aberrant EGFR-Ras and Hedgehog signaling. www.nature.com/articles/s41...nature.comHh and EGFR-Ras signaling promote distinct steps of tumor progression in the Drosophila follicle epithelium - Nature CommunicationsAberrant signaling pathway activation is a key driver of tumorigenesis. Using single-cell RNA sequencing, the authors unravel how EGFR-Ras and Hedgehog signaling promote distinct steps of tumor progre... 2113
Nuno Valente-Leal @nunovalenteleal.bsky.social · 25/03/2026The first preprint of the @zsantoslab.bsky.social has arrived!!! Ovaries control protein appetite - what about that? Are you curious to know how? Take a look below! Also, if you want to laugh a bit check the thread 🧵 012
Nuno Valente-Leal @nunovalenteleal.bsky.social · 13/03/2026‼️‼️ If you are interest on how Drosophila melanogaster integrates internal signals and environmental cues to regulate reproduction take a look at this book chapter! #fruitfly #drosophila #oogenesis 011
Nuno Valente-Leal @nunovalenteleal.bsky.social · 04/02/2026Last week, I had the pleasure of attending the 1st CAML&GIMM PhD meeting! I’m especially glad to have been part of the organizing team! Thank you to this amazing committee and everyone that contributed to making this meeting a success! See you again next year! 000
Nuno Valente-Leal @nunovalenteleal.bsky.social · 17/12/2025new lab, new blessings #fruitfly #drosophila #PhDlife 010
Nuno Valente-Leal @nunovalenteleal.bsky.social · 21/11/2025Just culturing Drosophila ovaries ex-vivo🪰! #Drosophila #fruitfly #PhDlife 130
Nuno Valente-Leal @nunovalenteleal.bsky.social · 11/11/2025Took the stage at the XI Portuguese Drosophila Research Meeting to discuss science, flies, and the alarming number of hours I spend counting eggs! Grateful for the discussions and the community! #drosophilaresearch #metabolism #drosophila #fruitfly 020
Reposted by Nuno Valente-LealAlex Gould Lab @alexgouldlab.bsky.social · 04/02/2025Our latest... Congrats to Seb Sorge, Victor Girard & coauthors for devising HolFast, a chemically defined (holidic) diet for #Drosophila development that performs almost as well as a yeast diet. If you study developmental #nutrition or #metabolism please try it out... www.cell.com/developmenta... 04216
Reposted by Nuno Valente-LealAndy Fraser @andyfraser.bsky.social · 04/02/2025Delighted to share our latest paper describing a method to read the levels of hundreds of metabolites or drugs in parallel using DNA sequencing. This method, which we call ‘smol-seq’ (Small MOLecule sequencing), harnesses the power of DNA sequencing for metabolite detection: rdcu.be/d8xLv (1/6)rdcu.beQuantifying metabolites using structure-switching aptamers coupled to DNA sequencingNature Biotechnology - Metabolites can be quantified using a combination of aptamers and DNA barcodes. 1115962