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Reposted by Ning Tsao

Nima Mosammaparast @nimamlab.bsky.social · 03/03/2025

A great pleasure to share our newest paper out this morning @cp-molcell.bsky.social. We show that damage to nascent RNAs should not be ignored, and under certain conditions, these can turn into DNA breaks. We call this phenomena RDIBs (RNA Damage Induced Breaks). www.cell.com/molecular-ce...

cell.com

YTHDC1 cooperates with the THO complex to prevent RNA-damage-induced DNA breaks

Tsao et al. uncover a novel pathway for genotoxicity, termed RNA-damage-induced DNA breaks (RDIBs). The mechanism for preventing RDIBs is orchestrated by YTHDC1 along with the THO complex, which funct...

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