Building on their landmark efforts to create cell-type atlases of adult brains using single-cell and spatial genomics technologies, researchers in the BRAIN ...

A 2022 paper was retracted after an independent team of researchers reanalyzed the data and questioned its validity.

The study used data filtering and statistical approaches that can yield spurious findings, but more rigorous methods can result in missed leads.

In the Nature paper “Spatial transcriptomics reveal neuron–astrocyte synergy in long-term memory” published on March 14th, 2024, authors Sun et al. claimed to identify cell-type specifi…

Nature - False positives in study of memory-related gene expression

Nature - False positives in study of memory-related gene expression

It may employ a kind of reasoning humans use all the time — but you’ve probably never heard of it.

ChIP-DIP (ChIP done in parallel) is a highly multiplex assay for protein–DNA binding, scalable to hundreds of proteins including modified histones, chromatin regulators and transcription factors, offe...