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Christian Nefzger

@nefzgerlab.bsky.social
2K followers 837 following 35 posts

Cell identity/Transcription factors/Aging/Maturation - Group Leader/PI at the IMB, University of Queensland, Brisbane, Australia

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Reposted by Christian Nefzger
ARMI @armilabs.bsky.social · 17/04/2026
Dr Christian Nefzger (Uni of QLD) presented at ARMI this week as part of our External Seminar Series. His work shows ageing is a structured process, reusing developmental mechanisms to reshape cell identity. It focuses on how transcription factor networks, including AP-1, regulate these changes.
Dr Christian Nefzger presenting at an ARMI seminar with a slide on ageing and transcription factor networks behind him.
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Reposted by Christian Nefzger
Chris Wells @stemcellsystems.bsky.social · 11/11/2025
Ralph Patrick is looking for dosage-sensitive transcription factors that may impact ageing #ASSCR2025 doi.org/10.1016/j.cm...
doi.org
Redirecting
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Reposted by Christian Nefzger
Shaun Mahony @shaunmahony.bsky.social · 18/11/2024
Really intriguing model of AP-1 driven aging. @anshulkundaje.bsky.social @suragnair.bsky.social - thinking of your AP1-related results in the ChromBPNet paper here...
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Christian Nefzger @nefzgerlab.bsky.social · 18/11/2024
🙏 to Manuel Serrano for writing a preview for our study @ Cell Metabolism. A pattern emerges in chromatin aging: AP-1 steals the show dlvr.it/TBvzgR
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Christian Nefzger @nefzgerlab.bsky.social · 18/11/2024
Thanks to Longevity Technology for writing an article about our recent study: "Master controller of aging and development uncovered. New insights into transcription factors and chromatin remodeling reveal potential for improving age-related health outcomes. #innovation #aging " t.co/a8Mxgowkbe
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Christian Nefzger @nefzgerlab.bsky.social · 18/11/2024
Thanks to EpiGenie for an article about our study: "Christian Nefzger's lab reveals how chromatin remodeling driven by the AP-1 pioneer transcription factor supports cell maturation. Beware o' the mechanism pirated during #aging to induce the appearance of age-related phenotypes!" bit.ly/3zOqBux
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Christian Nefzger @nefzgerlab.bsky.social · 18/11/2024
Our recent study in Cell Metabolism provides compelling evidence that chromatin accessibility and transcription factor network remodeling in aging reflect the predictable degrading effects of a mechanism initially driving organismal maturation. Link: doi.org/10.1016/j.cmet.2024.06.006 Thread 🧵👇1/9
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