The END nuclease targets eight phage families with at least ten different known DNA modifications, but not unmodified DNA. Its specificity is dictated by the C-terminal iEndoIII domain. To combat END,...

Analytic tools to characterize complex messenger RNA (mRNA) sequences are crucial for mRNA-based therapeutics and vaccines

Ongoing changes in human immunodeficiency virus (HIV) and hepatitis C virus (HCV) epidemiology highlight the need for more adaptable and accessible diagnostic tools. In this study, we developed a fast, low-cost test that detects HIV-1 and HCV from a sma...

Pseudolactococcus laudensis (formerly named Lactococcus laudensis) is an emerging lactic acid bacterium first isolated from raw milk in 2015 and subsequently detected in vegetables and dairy mesophili...

Characterizing viral strategies for circumventing cellular defenses is critical to understanding the biology and therapeutic application of bacteriophages as antimicrobials. Many bacteriophages synthesize complex modifications (i.e. hypermodifications) ...

In this Q&A, PeptiFinder Biotech scientists share how mRNA display yields the most potent peptide binder hits, where they see the field going, and what could expand the chemical space accessible to mR...

Abstract. Bacteriophage exclusion (BREX) defense systems restrict phage infection via inhibition of phage DNA replication, while also modifying and protect

Abstract. Toxin–antitoxin (TA) systems use diverse strategies to control bacterial growth and represent attractive therapeutic targets to fight pathogens.

Neuroinflammation is a key hallmark of both neurodegenerative and neurospecific autoimmune diseases, including multiple sclerosis (MS), where immune dysregulation contributes to cellular stress, autophagy, and disease progression in Alzheimer's disease ...

Abstract. We present a microfluidic workflow that couples reconstituted in vitro transcription–translation (IVTT) with ultrahigh-throughput droplet screeni

Wednesday, August 12th 1pm EDT The advancement of in vitro transcribed (IVT) mRNA therapeutics has driven demand for analysis methods that support consistent product quality and safety throughou...

Isolate total circulating cfRNA from biofluids with mag bead-based kit for downstream detection & sequencing workflows. Includes DNase.

RNase Inhibitor, Murine (Glycerol-free) is a glycerol-free version of RNase Inhibitor, Murine (NEB #M0314) that supports lyophilization and automation workflows

Creating the right partnership is essential when pioneering a new life science product. Every aspect of development – technical expertise

High-quality and pure RNA is a requirement for RNA therapeutics to avoid unwanted immune responses, not just a “nice to have.” In vitro transcription can be optimized, but additional cleanup may be ne...

Single-chain antibody fragments, like VHH and scFv, are increasingly popular in therapeutics due to their smaller size

Abstract. Replicative DNA synthesis is distributed among several DNA polymerases (DNAPs) in both Bacteria and Eukarya. The division of synthesis permits sp

Microbial-fungal symbioses are fundamental drivers of ecological networks and agricultural systems, orchestrating critical processes such as nutrient cycling...