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Reposted by Nazlı Akıllı

Daniel Jost - Physical Biology of Chromatin group @djost-physbiol.bsky.social · 10/09/2026

This great work by the Cavalli lab is finally out in @narjournal.bsky.social ! Congrats to all the team 🥂 and in particular Paul-Swann in our group who did the modeling part 👏. doi.org/10.1093/nar/...

doi.org

Loss of SUMOylation drives aberrant PRC1 clustering and 3D genome rewiring independent of H3K27me3

Abstract. Polycomb repressive complex 1 (PRC1) forms nuclear condensates that organize target chromatin domains. SUMOylation modulates PRC1 clustering, but

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