iiinova — where your digital self keeps evolving

Narayanan Lab @narayananlab.bsky.social · 01/09/2026

Vey excited that this paper is our – briefly, we show that 4 Hz STN DBS has the potential to improve cognitive control in PD patients with cognitive impairment, and the most dysfunctional 4 Hz activity. www.nature.com/articles/s41531-026-…

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Narayanan Lab @narayananlab.bsky.social · 07/04/2026

I've been quiet on social media recently - but I miss the opportunity to talk about all the cool things happening with other scientists since the days of Twitter. So - congrats to Hannah Stutt on defending her PhD on dorsal striatal dopamine and timing. Next step: on to awesome postdoctoral work!

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Narayanan Lab @narayananlab.bsky.social · 21/05/2025

Our work from a great collaboration now out at Brain Stimulation: doi.org/10.1016/j.br... We find that 4 Hz STN stimulation in *humans* changes decision thresholds: Data: narayanan.lab.uiowa.edu and osf.io/hsz3u With Rachel Cole and Jim Cavanagh

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Narayanan Lab @narayananlab.bsky.social · 21/05/2025

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Narayanan Lab @narayananlab.bsky.social · 14/05/2025

Lots more details in the paper. This paper challenged our fundamental view of what we think amphetamine does…

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Narayanan Lab @narayananlab.bsky.social · 14/05/2025

Amphetamine has been thought to reliably affect timing accuracy. We find in a meta-analysis and in our data that it actually more reliably affects precision:

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Narayanan Lab @narayananlab.bsky.social · 14/05/2025

Our work showing that amphetamine affects behavior by degrading prefrontal temporal variability is now out at Neuropharmacology: doi.org/10.1016/j.ne... Work by Matthew Weber and colleagues: As always, data and code at: narayanan.lab.uiowa.edu/datasets

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Narayanan Lab @narayananlab.bsky.social · 03/04/2025

New preprint from our group showing that drugs that enhance glycolysis slow neurodegeneration in Alzheimer's disease - data from yeast to humans: www.biorxiv.org/content/10.1... data: bit.ly/GlycolysisANDAD Data and code : narayanan.lab.uiowa.edu/home/data

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Narayanan Lab @narayananlab.bsky.social · 12/03/2025

What a great looking lab! Best of luck to Mackenzie Rysted at the University of Indiana...

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Narayanan Lab @narayananlab.bsky.social · 16/01/2025

How do we explain these results? We collaborated Rodica Curtu in math who implemented classic drift diffusion models. These DDMs suggest that D1 and D2 neurons provide temporal evidence. Disrupting them decreases the accumulation of temporal evidence – and predicts slowed timing. 5/5

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Narayanan Lab @narayananlab.bsky.social · 16/01/2025

We’ve previously reported that striatal neuron encode time by linear changes over a temporal interval – and we found that these linear changes in the striatum. However – to our complete surprise – D1 and D2 neurons had *opposite patterns* of ramping! 4/5

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Narayanan Lab @narayananlab.bsky.social · 16/01/2025

In line with our pharmacology data, we found that optogenetically inactivating either D2 or D1 MSNs slowed temporal control of action: 3/5

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Narayanan Lab @narayananlab.bsky.social · 16/01/2025

This works starts pharmacology showing that dopamine controls the timing of movement. Our work with blocking dopamine receptors systemically – and where they are most abundantly expressed – in the striatum -shows that blocking either D1 or D2 dopamine receptors slows temporal control of action:

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Narayanan Lab @narayananlab.bsky.social · 16/01/2025

Our latest work is up as a version of record on eLife. elifesciences.org/articles/96287 This story a long road – but is a major advance on understanding temporal control of action. As always, data and code are available at narayanan.lab.uiowa.edu/data 1/5

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Narayanan Lab @narayananlab.bsky.social · 20/12/2024

Long story short - we get great expression, and about what we might get from Cre mice. This will be a powerful tool for studying these circuits. They will be up at Jackson (039507) soon.

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Narayanan Lab @narayananlab.bsky.social · 20/12/2024

Youngcho integrated FlpO - another conditional expression construct - into the D1 gene. This is distinct from the D1 Cre mice, which uses BAC transgenics:

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Narayanan Lab @narayananlab.bsky.social · 17/12/2024

Very proud what our nascent Center for Neurodegeneration has done here in Iowa:

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Narayanan Lab @narayananlab.bsky.social · 15/11/2024

Wild - the term 'prefrontal' I think first appeared in 1878 in the journal Brain relating Phineas Gage and other lesions. For the human chauvinists out there - I think the term originates from fish skull anatomy, and in the first description - animal references abound:

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Narayanan Lab @narayananlab.bsky.social · 05/02/2024

As a reminder - here is the program: See you in May 15-17th @ NIH: narayanan.lab.uiowa.edu/cppc2024

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Narayanan Lab @narayananlab.bsky.social · 05/02/2024

Congrats to our Computational Properties of Prefrontal Cortex 2024 Travel Awardees! Kenji Lee-BU @kenjilee.bsky.social Rachel Dick-Univ of Minnesota Evan Hart-NIDA Habiba Azab-Baylor Justin Shin-Brandeis See you in May 15-17th @ NIH: narayanan.lab.uiowa.edu/cppc2024

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Narayanan Lab @narayananlab.bsky.social · 24/01/2024

Out in NPJ Parkinson's disease pubmed.ncbi.nlm.nih.gov/38172519/ engineering.uiowa.edu/news-all/202... Resting-state EEG *strongly* predicts cognition in Parkinson’s disease.

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Narayanan Lab @narayananlab.bsky.social · 09/11/2023

Check out posters at #SFN23 this year. I have to stay home - but we've got some fascinating science to present!

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Narayanan Lab @narayananlab.bsky.social · 10/10/2023

Congrats to Xin Ding for winning a fellowship from Iowa's graduate college!

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Narayanan Lab @narayananlab.bsky.social · 25/09/2023

Congrats to Alex Bova on her newly funded F32! reporter.nih.gov/search/tUxfE...

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Narayanan Lab @narayananlab.bsky.social · 14/09/2023

For my first bsky post: We are proud to announce 8th Computational Properties of Prefrontal Cortex Workshop May 15-17th 2024 at NIH! Registration: bit.ly/CPPC2024 (hurry - there are only ~80 slots) More info: narayanan.lab.uiowa.edu/cppc2024 Itinerary below - and in modern parlance - is 🔥 🔥 🔥

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