Reposted by Nan Xu
💫NEW: @studerl.bsky.social , Ciceri & co present a whole-genome CRISPR-Cas9 knockout screen using directed differentiation systems. They find that MEN1 and SUZ12 modulate human developmental timing by epigenetically controlling bivalent promoters of developmental genes.
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Genome-wide CRISPR screen identifies Menin and SUZ12 as regulators of human developmental timing - Nature Cell Biology
Xu et al. perform a whole-genome CRISPR-Cas9 knockout screen using directed differentiation systems. They find that MEN1 and SUZ12 modulate human developmental timing by epigenetically controlling biv...