Reposted by @myadla.bsky.socialBrammah R Thangarajah @kidneying.bsky.social · 31/07/2025#ECNeph @brammahin @Dilushiwijay @myadla @acssjr @dra_miliflores pubmed.ncbi.nlm.nih.... pubmed.ncbi.nlm.nih.... ☄️ More than few reported cases exist 052
Reposted by @myadla.bsky.socialBrammah R Thangarajah @kidneying.bsky.social · 31/07/2025ℹ️Turns out patient has hypogammaglobulinemia ❓MMF related/disease related Ig A - 134 mg/dl ( 70-400) ⬇️Ig G - 669 mg/dL (700-1600) ⬇️⬇️Ig M - 38 mg/dL (40-230) 😏Does it explain all? #ECNeph @brammahin @Dilushiwijay @myadla @acssjr @dra_miliflores 042
myadla.bsky.social @myadla.bsky.social · 31/07/2025How to differeentiate flare from infection ? Any novel markers #ECNeph 141
Reposted by @myadla.bsky.socialBrammah R Thangarajah @kidneying.bsky.social · 31/07/2025#ECNeph @brammahin @myadla @Dilushiwijay @acssjr @dra_miliflores @Dilushiwijay @ISNkidneycare Admitted with febrile illness Flare vs infection Any other DD ? Thoughts plz ! Mild rise in creatinine Kidney Bx : Now Class III LN 152
Reposted by @myadla.bsky.socialBrammah R Thangarajah @kidneying.bsky.social · 31/07/2025#ECNeph @brammahin @myadla @ISNkidneycare @Dilushiwijay @acssjr @dra_miliflores Class switching in LN Bomback AS. Nonproliferative Forms of Lupus Nephritis: An Overview. Rheum Dis Clin North Am. 2018 Nov;44(4):561-569 062
myadla.bsky.social @myadla.bsky.social · 31/07/2025Common diagnosis in this age group of rhematological category is lupus ..Need to see whether shes satisfying criteria #ECNeph 040
Reposted by @myadla.bsky.socialAugusto Cesar S Santos Jr @acssjr.bsky.social · 31/07/2025Let start the discussion! 23 YO women with Lupus and recurrent admissions #ECNeph @kidneying.bsky.social @myadla.bsky.social @dilushiwijay.bsky.social @dramiliflores.bsky.social 153
myadla.bsky.social @myadla.bsky.social · 31/07/2025Hi #ECNeph Dr Manjusha From India Eager to learn 030
Reposted by @myadla.bsky.socialBrammah R Thangarajah @kidneying.bsky.social · 31/07/2025#ECNeph @brammahin @myadla @Dilushiwijay @acssjr @dra_miliflores @Dilushiwijay @ISNkidneycare Is the diagnosis obvious ? Should we check labs? ANA+VE/low C3/hemat /Musculo skeletal involvement /Kidney Biopsy done in v/o proteinuria : Class 1 Can it be podocytopathy 152
myadla.bsky.social @myadla.bsky.social · 30/06/2025Thank you for a good case prsentation @karnephro.bsky.social #ECNeph @dilushiwijay.bsky.social @theisn.orgmedia.tenor.coma penguin wearing a black hat with the words thank you above itALT: a penguin wearing a black hat with the words thank you above it 040
myadla.bsky.social @myadla.bsky.social · 30/06/2025Recent publication from CKJ @karnephro.bsky.social #ECNeph @dilushiwijay.bsky.social @theisn.org 020
Reposted by @myadla.bsky.socialShubharthi Kar @karnephro.bsky.social · 30/06/2025⚡️PLA2R antibody seropositivity doesn’t mean that we do not investigate for underlying malignancies. Here is a Case Report showing PLA2rAb MN having Carcinoma Oesophagus #ECNeph @theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social 041
Reposted by @myadla.bsky.socialShubharthi Kar @karnephro.bsky.social · 30/06/2025KDIGO recommends Population and Age-appropriate Screening for malignancies irrespective of antigen status #ECNeph @theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social 051
Reposted by @myadla.bsky.socialISNkidneycare @theisn.org · 30/06/2025Yes, some tests came after biopsy #ECNEPh 021
myadla.bsky.social @myadla.bsky.social · 30/06/2025@karnephro.bsky.social #ECNeph @dilushiwijay.bsky.social @theisn.org 020
myadla.bsky.social @myadla.bsky.social · 30/06/2025Check the distribution of solid malignancies in NS @karnephro.bsky.social #ECNeph @dilushiwijay.bsky.social @theisn.org 010
myadla.bsky.social @myadla.bsky.social · 30/06/2025Differentiating between PMN and SMN @karnephro.bsky.social #ECNeph @dilushiwijay.bsky.social @theisn.org 020
Reposted by @myadla.bsky.socialISNkidneycare @theisn.org · 30/06/2025Final Diagnosis #ECNeph @dramiliflores.bsky.social @karnephro.bsky.social @myadla.bsky.social @dilushiwijay.bsky.social 031
Reposted by @myadla.bsky.socialShubharthi Kar @karnephro.bsky.social · 30/06/2025👉 🫣 Can IF differentiate from Primary and Secondary MN? IgG 4 is the dominant class in primary MN 👉 IgG1,IgG2, IgG3 are dominant Immunoglobulins in Secondary MN #ECNeph @theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social 121
myadla.bsky.social @myadla.bsky.social · 30/06/2025Paraneoplastic glomerulopathies @karnephro.bsky.social #ECNeph @dilushiwijay.bsky.social @theisn.org 020
myadla.bsky.social @myadla.bsky.social · 30/06/2025Some more info about PNS ! @karnephro.bsky.social #ECNeph @dilushiwijay.bsky.social @theisn.org 030
myadla.bsky.social @myadla.bsky.social · 30/06/2025@karnephro.bsky.social #ECNeph @dilushiwijay.bsky.social @theisn.org Paraneoplastic glomerulopathy can occur before /sfter or simultaneously with the diagnosis of MN Need for evaluation of cases of MN for underlying malignancy is suggested 030
Reposted by @myadla.bsky.socialISNkidneycare @theisn.org · 30/06/2025Primary vs Secondary Membranous Nephropathy #ECNeph springer.com... @dramiliflores.bsky.social @karnephro.bsky.social 031
Reposted by @myadla.bsky.socialISNkidneycare @theisn.org · 30/06/2025🔬 The characteristic histopathologic features of MN, light microscopy, IF, EM, are falling into place. So… where are we in this case? Granular IgG, GBM thickening, no crescents... What do you think? #ECNeph @dramiliflores.bsky.social @karnephro.bsky.social www.ajkd.org/action/... 042
Reposted by @myadla.bsky.socialISNkidneycare @theisn.org · 30/06/2025A positive anti-PLA2R antibody test is “virtually” diagnostic of a lesion of MN (but may not always be able to reliably distinguish primary and secondary forms) #ECNeph #MedSky #NephSky @kdjhaveri.bsky.social @dramiliflores.bsky.social @karnephro.bsky.social 141
Reposted by @myadla.bsky.socialShubharthi Kar @karnephro.bsky.social · 30/06/2025Different types of tumor secrete different types of antigen. Here is the proposed mechanism of malignancy associated MN. #ECneph @dramiliflores.bsky.social @myadla.bsky.social @theisn.org www.frontiersin.org/journals/med... 031
myadla.bsky.social @myadla.bsky.social · 30/06/2025Great infographic about NS in elderly @karnephro.bsky.social #ECNeph @dilushiwijay.bsky.social @theisn.org 010
myadla.bsky.social @myadla.bsky.social · 30/06/2025Genetic testing for elderly ? Any lit supporting this ? @karnephro.bsky.social #ECNeph @dilushiwijay.bsky.social @theisn.org 130
myadla.bsky.social @myadla.bsky.social · 30/06/2025Elderly with massive proteinuria Membranous nephropthy Amyloidosis Dn if (pt is DM) FSGS #ECNeph @karnephro.bsky.social #ECNeph @dilushiwijay.bsky.social @theisn.org 120
myadla.bsky.social @myadla.bsky.social · 30/06/2025@karnephro.bsky.social #ECNeph @dilushiwijay.bsky.social @theisn.org Searching for clues .....media.tenor.coma cartoon mouse is peeking out from behind a wall and covering his face .ALT: a cartoon mouse is peeking out from behind a wall and covering his face . 020
myadla.bsky.social @myadla.bsky.social · 30/06/2025Thankyou @karnephro.bsky.social for sharing case details #ECNeph @dilushiwijay.bsky.social @theisn.org 020
Reposted by @myadla.bsky.socialShubharthi Kar @karnephro.bsky.social · 30/06/2025Hello Shubharthi ,From Sylhet, Bangladesh .Thank you @theisn.org for selecting our case from #Bangladesh No COI #ECneph 121
Reposted by @myadla.bsky.socialISNkidneycare @theisn.org · 30/06/2025 Please introduce yourself, tell us where you're joining from, and don’t forget to use #ECNeph! 💬 Let’s keep learning together, let´s join the case chat now! 🎓🩺 011
myadla.bsky.social @myadla.bsky.social · 30/06/2025Hi @myadla.bsky.social joining from India No COI #ECNeph 110
Reposted by @myadla.bsky.socialISNkidneycare @theisn.org · 30/06/2025🎙️ Milagros Flores, @dramiliflores.bsky.social 🇭🇳 🇲🇽 I’m your host today #ECNeph No COI. On the other side @karnephro.bsky.social 🙌 Let’s get started! #MedSky #NephSky @theisn.org Are you ready to learn, discuss, and share your thoughts?💥 031
Reposted by @myadla.bsky.socialISNkidneycare @theisn.org · 30/06/2025⏳ 60 min to go! 👣 Let’s walk through proteinuria findings 🧪🌳 🗓️ Join today for our #ECNeph Case Discussion 🕛 30th June 2025 at 12 PM EST @dramiliflores.bsky.social @karnephro.bsky.social Are you ready? #MedSky #NephSky 022
myadla.bsky.social @myadla.bsky.social · 30/06/2025Dont miss Join us in 20 min #ECNeph @theisn.org @dilushiwijay.bsky.social 010
Reposted by @myadla.bsky.socialMilagros Flores @dramiliflores.bsky.social · 30/06/2025🧪 Proteinuria: Not a Walk in the Park 👣 Could this be more than just "nephrotic syndrome"? 🕵️ 🗓️ Join us #ECNeph Chat on Bluesky 🕛 30th June 2025, 12 PM EST @dramiliflores.bsky.social @karnephro.bsky.social @theisn.org #NephSky #MedSky @theisn.org 042
Reposted by @myadla.bsky.socialDilushi Wijayaratne @dilushiwijay.bsky.social · 30/05/2025Hi this is Dilushi, joining a bit late! And lurking tonight #ECNeph 141
Reposted by @myadla.bsky.socialAS @renfamilia.bsky.social · 30/05/202515/n Diagnostic algorithm for IgG4-RKD Diagnosis = Multimodal 🧠 High suspicion in AIN w/ low complement 🔬 Biopsy: Storiform fibrosis, IgG4+ PCs >10/hpf 🧪 Supportive labs & imaging 📊 Diagnostic criteria evolving (2011 → 2020 updates) #ECNeph @myadla.bsky.social @dramiliflores.bsky.social 021
Reposted by @myadla.bsky.socialAS @renfamilia.bsky.social · 30/05/202518/n IgG4-TIN Treatment Case Series 🩺 📄https://pubmed.ncbi.nlm.nih.gov/21719792/ 📉 Treatment Response: Most patients responded dramatically to corticosteroids #ECNeph @myadla.bsky.social @dramiliflores.bsky.social @theisn.org 021
Reposted by @myadla.bsky.socialGabriela Amador @gabyneph.bsky.social · 31/05/2025Let’s follow this clinical case that @renfamilia.bsky.social , @dramiliflores.bsky.social and @myadla.bsky.social prepared for us! Follow the 🧵 021
Reposted by @myadla.bsky.socialAS @renfamilia.bsky.social · 30/05/202520/n MITIGATE trial- Inebilizumab 💊 Steroid sparing effect, ↓flare 🛡️ Immunosuppression for relapsers 💉 Inebilizumab – 1st FDA-approved drug for IgG4-RD 💰 Costly (~$150k/30 mL) 📖 www.nejm.org/doi/full/10.1056/NEJMo… #ECNeph @myadla.bsky.social @dramiliflores.bsky.social @theisn.org 121
Reposted by @myadla.bsky.socialAS @renfamilia.bsky.social · 30/05/2025Glad to have discussed the case for #ECNeph. Thank you all for your support and guidance! @myadla.bsky.social @dramiliflores.bsky.social @dilushiwijay.bsky.social @theisn.org 🙌 032
myadla.bsky.social @myadla.bsky.social · 30/05/2025Often underdiagnosed Are there any bioomarkers #ECNeph 110
Reposted by @myadla.bsky.socialAS @renfamilia.bsky.social · 30/05/202523/n Conclusion 🔚 Once an elusive mystery, IgG4-RD was hard to spot and often misdiagnosed. 🌊 But decades of research have turned the tide. ✨ Today, IgG4-RD stands in the spotlight—defined, diagnosable, and treatable. #ECNeph @myadla.bsky.social @dramiliflores.bsky.social @theisn.org 131
Reposted by @myadla.bsky.socialAS @renfamilia.bsky.social · 30/05/202517/n IgG4-RD-Pathophysiology and Novel Targets 🎯B-T cell collaboration seems to be central to the pathophysiology of IgG4-RD at different levels #ECNeph @myadla.bsky.social @dramiliflores.bsky.social @dilushiwijay.bsky.social @theisn.org 021
