iiinova — where your digital self keeps evolving

Reposted by Mustafa Alaabo

Gerlich Lab @gerlichlab.bsky.social · 06/05/2026

New preprint out!🧬 How do cells keep replicated sister chromatids linked for DNA repair while folding 3D loops for gene expression? Extrusion folds DNA but separates sisters, while cohesion connects them, risking mutual interference. How do they coexist?🧵👇 🔗 doi.org/10.64898/2026.05.02.722390 1/6

doi.org

25422

Mustafa Alaabo @mualaabo.bsky.social · 25/02/2026

Congratulations to @mfdspicer.bsky.social and all co-authors on this awesome work 🥳🤩 I'm happy to have made a tiny contribution to the paper

030

Reposted by Mustafa Alaabo

Aurele Piazza @aurelepiazza.bsky.social · 06/01/2026

SMC and recombination enthusiasts: we updated our work describing the loop extrusion properties of budding yeast condensin and its function in biasing donor usage for mating-type switching. Lots of cool new data, check it out! www.biorxiv.org/content/10.1...

13824

Reposted by Mustafa Alaabo

Aurele Piazza @aurelepiazza.bsky.social · 27/08/2025

Transcription and recombination are two universal DNA-dependent processes, but how they are coordinated remains largely unknown. Here we characterized transcription-recombination priority rules in yeast. 🧵 www.embopress.org/doi/full/10....

12914

Reposted by Mustafa Alaabo

Gerlich Lab @gerlichlab.bsky.social · 03/09/2025

1/ New preprint alert! In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis. 🔗 doi.org/10.1101/2025...

doi.org

An electrostatic repulsion model of centromere organisation

During cell division, chromosomes reorganise into compact bodies in which centromeres localise precisely at the chromatin surface to enable kinetochore-microtubule interactions essential for genome se...

26827

Reposted by Mustafa Alaabo

Institute of Molecular Biotechnology @imbavienna.bsky.social · 01/08/2025

Congratulations to Mustafa Alaabo, PhD student in Daniel Gerlich’s lab, who was awarded a competitive fellowship by the Boehringer Ingelheim Fonds for his research on DNA repair by homologous recombination.

072

Reposted by Mustafa Alaabo

Karolin Luger @nucleosomepolice.bsky.social · 26/07/2025

if i were a better person i would do a tweetorial on our recent paper - but, hey, read the paper. its right there, waiting for you. #Giantvirus #histones are cool! their #nucleosomes are cool. check it out.! thats the tweetorial. rdcu.be/exXBX

18419

Reposted by Mustafa Alaabo

Janet Iwasa @jiwasa.bsky.social · 02/07/2025

Check out this new review (with animations, natch) of mechanisms of licensing origins of DNA replication - a wonderful (and continuing!) collaboration with Bruce Stillman @cshlnews.bsky.social and John Diffley @crick.ac.uk! www.nature.com/articles/s41...

68144