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@msresearchhub.bsky.social
77 followers 319 following 14 posts

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MS Research Hub @msresearchhub.bsky.social · 01/10/2026
A 28-year-old army officer went to the Scottish Highlands in December 1822 to visit a relative he loved like a father. When he got there, the man was already dead. Shortly after the funeral his eyes started to fail. His diary is often called the earliest first-person account of probable MS 🧵
Handwritten diary page headed "1822. The Death of Strowan.— Effect upon my Eyes.—" It reads: "In the month of December 1822 I travelled from Ramsgate to the Highlands of Scotland for the purpose of passing some days with a Relation for whom I had the affection of a Son. On my arrival I found him dead.— I attended his funeral:— there being many persons present I struggled violently not to weep, I was however unable to prevent myself from so doing:— Shortly after the funeral I was obliged to have my letters read to me, and their answers written for me, as my eyes were". The words "violently not to weep" are underlined. Plate from Firth, The Case of Augustus d'Esté (1948). Wellcome Collection, CC BY 4.0.
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Joe Sabatino @jsabatino37.bsky.social · 22/07/2026
Anti-CD20 B cell depletion is associated with elevated mucosal-originating circulating regulatory IgA B cells in multiple sclerosis www.science.org/doi/10.1126/...
science.org
Anti-CD20 B cell depletion is associated with elevated mucosal-originating circulating regulatory IgA B cells in multiple sclerosis
Anti-CD20 B cell depletion augments mucosal regulatory IgA B cell trafficking in multiple sclerosis.
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Joe Sabatino @jsabatino37.bsky.social · 07/06/2026
Single-cell analysis of skin and blood reveals systemic immune responses to ultraviolet B and their impairment in MS link.springer.com/article/10.1...
link.springer.com
Single-cell analysis of skin and blood reveals systemic immune responses to ultraviolet B and their impairment in MS - Journal of Neuroinflammation
Sunlight is a fundamental immune-modulating factor with implications for the pathogenesis of autoimmune diseases such as multiple sclerosis (MS). MS incidence and severity increase with latitude, hist...
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Joe Sabatino @jsabatino37.bsky.social · 02/03/2026
Epstein-Barr Virus Infection at Single-Cell Resolution onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Epstein‐Barr Virus Infection at Single‐Cell Resolution
Epstein-Barr virus (EBV) infection has been studied at single-cell resolution for six decades and counting. Such investigations can reveal virus-host interactions and their dependence on viral strain...
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MS Research Hub @msresearchhub.bsky.social · 10/02/2025
I started a substack to capture some thoughts. Please give me feedback. open.substack.com/pub/msliving...
open.substack.com
Inbox | Substack
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MS Research Hub @msresearchhub.bsky.social · 15/01/2025
📚 New study shows marriage is linked to better brain health in MS patients. Married people with MS had: Fewer brain lesions Higher brain volume Better preserved grey matter Even after controlling for factors like medication adherence, lifestyle & disease duration. Study: doi.org/10.1007/s004...
doi.org
Marriage is associated with decreased lesion volumes and less brain atrophy in people with multiple sclerosis - Journal of Neurology
Background Married or long-term partnered patients with chronic diseases generally have better outcomes than unmarried patients, likely due to the potential for multifaceted support. However, the impa...
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MS Research Hub @msresearchhub.bsky.social · 04/12/2024
Fresh Study: 3mg nightly melatonin for 12 weeks improved heart function, reduced oxidative stress, AND enhanced sleep quality in MS patients! Could be a simple but powerful addition to MS care. pubmed.ncbi.nlm.nih.gov/39630381/ #MS #Melatonin
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MS Research Hub @msresearchhub.bsky.social · 02/12/2024
Study from Iran: 10 MS patients safely switched from anti-CD20 to lower-intensity treatments. After 18 months, no disease progression seen. Suggests de-escalation could be viable for stable patients to reduce long-term risks. pubmed.ncbi.nlm.nih.gov/39619757/ #MS #CD20
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