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Mark Hartmann @mphartmann.bsky.social · 06/12/2025

Multi-omics integration reveals risk-associated gene expression signatures, identifying CD52 as a potential therapeutic target for high-risk JMML. Anti-CD52 treatment depletes JMML stem cells and disrupts disease propagation in a JMML PDX model.

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Mark Hartmann @mphartmann.bsky.social · 06/12/2025

RAS-pathway mutations induce fetal-like gene expression programs in a JMML mouse model, suggesting RAS-driven oncofetal reprogramming in murine JMML stem cells.

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Mark Hartmann @mphartmann.bsky.social · 06/12/2025

Fetal HSC signatures are enriched in patients without detectable JMML driver mutations at birth.

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Mark Hartmann @mphartmann.bsky.social · 06/12/2025

JMML stem cells show transcriptional plasticity, hijacking parts of distinct developmental programs, including fetal HSC marker genes, leading to mosaic-like developmental expression programs. This suggests the reactivation rather than preservation of oncofetal signatures.

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Mark Hartmann @mphartmann.bsky.social · 06/12/2025

The postnatal maturation state of JMML stem cells challenges the universality of the maturation block model in pediatric malignancies.

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Mark Hartmann @mphartmann.bsky.social · 06/12/2025

JMML epitypes are prognostic biomarkers in JMML. Conservation of such disease-specific epigenetic signatures in HSC-like JMML stem cells and downstream immune cells suggests HSCs or early HSPCs as the cells-of-origin in JMML across JMML epitypes.

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Mark Hartmann @mphartmann.bsky.social · 06/12/2025

Epigenomes encode cell type, developmental state, and disease-specific information. DNA methylomes of JMML stem cells reveal: 1. HSC-like cell type signatures 2. A postnatal maturation state 3. Disease-specific epitypes

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Mark Hartmann @mphartmann.bsky.social · 06/12/2025

ONLINE FIRST ALERT! Molecular #Plasticity Results in #Oncofetal #Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia aacrjournals.org/bloodcancerd... @aacrjournals.bsky.social #childhoodcancer #epigenetics #precisiononcology

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Mark Hartmann @mphartmann.bsky.social · 26/09/2025

Pioneers of Epigenetics honored: Davor Solter & Azim Surani receive the 2026 Paul Ehrlich & Ludwig Darmstaedter Prize. Their discovery of genomic imprinting revealed why mammals need both parents—opening the field of epigenetics. #Epigenetics #GenomicImprinting #PaulEhrlichPrize #CanSky #Science

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Mark Hartmann @mphartmann.bsky.social · 28/02/2025

Actually, not so rare at all! #RareDiseaseDay Affecting a substantial part of human kind! Support research on rare diseases! Picture from rarediseaseday.org

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Mark Hartmann @mphartmann.bsky.social · 15/11/2024

What a fantastic meeting! Thrilled to welcome Frank Westermann, Katrin Ottersbach, and Jan-Henning Klusmann to the @dkfz.bsky.social to dive into the developmental origins of #ChildhoodCancers.

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Mark Hartmann @mphartmann.bsky.social · 08/11/2024

Excited to announce the upcoming 80th Heidelberg Grand Round on "Developmental Signatures and Molecular Plasticity in Cancer"! Heidelberg, on Nov 14, 2024, from 4:00-6:00 PM. Explore #Cancer as a developmental disease! @dkfz.bsky.social NCT Heidelberg Universitätsklinikum Heidelberg

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Mark Hartmann @mphartmann.bsky.social · 05/05/2024

Exciting insights by Andi Roy into the role of the fetal HSPC marker LIN28B on human lymphopoiesis and infant ALL at the EMBO Workshop Intercepting Childhood Blood Cancer in Düsseldorf. #ChildhoodCancer #bloodsky

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Mark Hartmann @mphartmann.bsky.social · 03/05/2024

Great talk from @laurenmharmon.bsky.social from @timtriche.bsky.social lab about germline variant burden in pediatric AML. #bloodsky

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Mark Hartmann @mphartmann.bsky.social · 15/02/2024

Today is #internationalchildhoodcancerday! 🎗️ Picture from KITZ - Hopp Children‘s Cancer Center Heidelberg

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Mark Hartmann @mphartmann.bsky.social · 09/02/2024

Do you think fetal transcription signatures are the consequence of a maturation block of a prenatal cell-of-origin in #childhoodcancer ? This might not always be true! Evidence for #oncofetal #reprogramming can be found in our new preprint @dblipka.bsky.social www.biorxiv.org/content/10.1...

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