iiinova — where your digital self keeps evolving

Reposted by @mosheparnas.bsky.social

Carolina Rezaval @crezaval.bsky.social · 09/03/2026

The School of Biosciences @unibirmingham.bsky.social is recruiting five Assistant/Associate Professors working across a range of areas, including neuroscience. Join a vibrant interdisciplinary research environment. Deadline: 14 April 2026 edzz.fa.em3.oraclecloud.com/hcmUI/Candid...

edzz.fa.em3.oraclecloud.com

Assistant or Associate Professor (Research and Education) - School of Biosciences - 107106 - Grade 8 or 9

Evidence of a developing track record in publishing work of high academic quality and impact is essential, as is an emerging portfolio (or clear potential) of external research funding. Applicants mus...

11522

mosheparnas.bsky.social @mosheparnas.bsky.social · 11/02/2026

6/6 Read the full study here: doi.org/10.1016/j.cu...

doi.org

Redirecting

000

mosheparnas.bsky.social @mosheparnas.bsky.social · 11/02/2026

5/6 We also would like to thank once again our wonderful editor Rita Gemayel and the reviewers for a very efficient and pleasant review process.

100

mosheparnas.bsky.social @mosheparnas.bsky.social · 11/02/2026

4/6 A huge congratulations to lead author Julia Manoim Wolkovitz and our collaborators at @unicologne.bsky.social and the Open University of Israel!

100

mosheparnas.bsky.social @mosheparnas.bsky.social · 11/02/2026

3/6 When a critical signal hits, the neuron’s electrical state changes, flipping the switch "off" to allow rapid, efficient memory formation. This allows the brain to be both incredibly sensitive and highly accurate, minimizing both Type I and Type II errors.

100

mosheparnas.bsky.social @mosheparnas.bsky.social · 11/02/2026

2/6 We discovered that a single receptor, mAChR-B, acts as a voltage-dependent switch in the brain. When neurons are quiet, the receptor suppresses "false positive" learning, preventing the brain from forming incorrect associations from random noise.

100

mosheparnas.bsky.social @mosheparnas.bsky.social · 11/02/2026

1/6 Check out our new study in @currentbiology.bsky.social that examines how our brain accommodates for two opposing demands - efficient and yet accurate learning. 🧵👇

152

mosheparnas.bsky.social @mosheparnas.bsky.social · 03/02/2026

Congratulations Shai! Very proud to be a part of this project.

021

mosheparnas.bsky.social @mosheparnas.bsky.social · 20/03/2025

4/ We would like to thank our editor Rita Gemayel and the reviewers for a very efficient and pleasant review process.

000

mosheparnas.bsky.social @mosheparnas.bsky.social · 20/03/2025

3/ Excitation of highly active glomeruli results in odor decorrelation. Indeed, knockdown of mAChR-B increases correlation between odors representation in the brain and decreases flies’ odor discrimination capabilities.

110

mosheparnas.bsky.social @mosheparnas.bsky.social · 20/03/2025

2/ We uncover a novel mechanism for signal decorrelation which is based on intraglomerular excitation and works in synergism with lateral interglomerular inhibition. This intraglomerular excitation is mediated by mAChR-B and it only occurs at high neuronal activity.

100

Reposted by @mosheparnas.bsky.social

Katrin Vogt @katrinvogt.bsky.social · 07/12/2024

This exciting new paper about the neural mechanisms underlying classical and operant learning in flies 🪰 is finally out - it matters which paradigm you use to test your animals!

1124

Reposted by @mosheparnas.bsky.social

Carolina Rezaval @crezaval.bsky.social · 06/12/2024

New from Shiko Parnas' lab: Classical & operant learning in *Drosophila* rely on distinct neuronal pathways, challenging current paradigms! Unstoppable www.science.org/doi/10.1126/...

science.org

Neuronal circuit mechanisms of competitive interaction between action-based and coincidence learning

Parallel and interfering neuronal circuits are responsible for operant and classical learning.

12111

Reposted by @mosheparnas.bsky.social

Carolina Rezaval @crezaval.bsky.social · 15/11/2024

Sex or survival—what’s more important? Excited to share our @Nature paper on how flies resolve this conflict. We found a dopamine-based filter that reduces threat perception, helping flies focus on courtship when close to mating. www.nature.com/articles/s41...

nature.com

Mating proximity blinds threat perception - Nature

A state-dependent dopamine filter system in the male Drosophila brain balances threat perception against the drive to mate.

03012

Reposted by @mosheparnas.bsky.social

Eyal Rozenfeld @eyalrozenfeld.bsky.social · 08/12/2024

7/ 🌐 The Big Picture: Our findings challenge the long-held belief that these memories just stack up together. Instead, there’s a tug-of-war, and your brain actively picks sides. This discovery could change how we study learning, from flies to humans.

031

Reposted by @mosheparnas.bsky.social

Eyal Rozenfeld @eyalrozenfeld.bsky.social · 08/12/2024

6/ 🔍 Why Should We Care?: This isn’t just about flies—it’s a peek into how our own brains might handle competing memories. Imagine the implications for understanding decision-making, multitasking, or even mental health! 🤯

121

Reposted by @mosheparnas.bsky.social

Eyal Rozenfeld @eyalrozenfeld.bsky.social · 08/12/2024

5/ 🧠 Neural Circuit Plot Twist: We found that operant learning taps into the brain’s navigation center (CX). The CX actively blocks classical learning, allowing operant memory to form without interference. It’s like having a bouncer neuron guarding the dance floor of your memories! 💃🧠

131

Reposted by @mosheparnas.bsky.social

Eyal Rozenfeld @eyalrozenfeld.bsky.social · 08/12/2024

4/ 🏃‍♂️ The Behavior Shift: Here’s where it gets wild: After classical learning, flies freeze when they smell the conditioned odor. But after operant learning, they actively avoid it! This active vs. passive response hints at different cognitive processes, even for the same stimulus.

131

Reposted by @mosheparnas.bsky.social

Eyal Rozenfeld @eyalrozenfeld.bsky.social · 08/12/2024

3/ 🧩 Surprise! They Clash: Turns out, the two types of memories compete. When flies try to form both at once, they end up learning… nothing. It’s like trying to follow two GPS directions at the same time. One system has to take charge, or it all falls apart.

131

Reposted by @mosheparnas.bsky.social

Eyal Rozenfeld @eyalrozenfeld.bsky.social · 08/12/2024

2/ 💥 Classical vs. Operant Conditioning: Classical (Pavlovian) learning is when you passively associate a cue with an outcome (think Pavlov’s dogs 🐶🔔). Operant learning is active—you have to make a choice to change the outcome. But what happens when both collide? 🧐

121

Reposted by @mosheparnas.bsky.social

Eyal Rozenfeld @eyalrozenfeld.bsky.social · 08/12/2024

1/ 🧠 Ever wondered how different types of learning coexist in our brains? Spoiler: Sometimes, they don’t! Our new study flips the script on what we thought about memory and learning in Drosophila. Dive in for a surprising twist! 🧵👇 www.science.org/doi/10.1126/...

3126

mosheparnas.bsky.social @mosheparnas.bsky.social · 08/12/2024

6/ Implications for Cognitive Science: Our findings challenge the hierarchical model of learning. Instead of additive memory formation, active processes separate these memories, allowing distinct behavioral strategies.

030

mosheparnas.bsky.social @mosheparnas.bsky.social · 08/12/2024

5/ Neuronal Circuit Insights: Operant learning requires the fly's navigation center (CX). CX activity gates plasticity, allowing operant learning while preventing interference from classical learning pathways. This active gating mechanism is key to resolving conflicting memories.

110

mosheparnas.bsky.social @mosheparnas.bsky.social · 08/12/2024

4/ Behavioral Differences: Flies show distinct behaviors after different types of conditioning. While classical learning leads to freezing, operant learning prompts active avoidance. This mirrors findings in mammalian studies suggesting shared cognitive principles across species.

110

mosheparnas.bsky.social @mosheparnas.bsky.social · 08/12/2024

3/ 🧑‍🔬 Surprising Discovery: Contrary to the dogma, we show that operant and classical learning cannot happen at the same time. If both forms of plasticity occur simultaneously, they interfere, leading to no effective learning. 🤯

110

mosheparnas.bsky.social @mosheparnas.bsky.social · 08/12/2024

2/ Classical vs. Operant Learning: Classical conditioning is passive, where an association is formed between a cue and an outcome. Operant conditioning is active, requiring the animal's action to influence the outcome. These different strategies involve separate brain circuits.

110

mosheparnas.bsky.social @mosheparnas.bsky.social · 08/12/2024

1/ How do animals integrate different forms of learning? Our @eyalrozenfeld.bsky.social new study in Science Advances shows that active mechanisms prevent the co-formation of competing memories. Here’s what we found! 🧵👇 science.org/doi/10.1126/...

21510