Miriam Molina-Arcas @molinaarcas.bsky.social · 20/09/2026Led by the talented Mona Tomaschko, this was a fantastic team effort. Very proud of the work and grateful to everyone who contributed! #Downwardlab 000 0
Miriam Molina-Arcas @molinaarcas.bsky.social · 20/09/2026We show that combination therapies that stimulate antitumour immunity promote the immune-mediated elimination of KRAS-G12C inhibitor-resistant subpopulations, providing a potential strategy to overcome drug resistance that may have relevance in broader therapeutic settings. #KRAS #DrugResistance 100 0
Miriam Molina-Arcas @molinaarcas.bsky.social · 20/09/2026A bit late posting this, but our latest paper was finally published in the September issue of Cancer Research. (1/3) doi.org/10.1158/0008...doi.orgKRAS Inhibitor–Induced Cancer Cell Death Enhances Sensitivity to Immune-Mediated Bystander Killing of Drug-Resistant SubclonesCombination therapies that stimulate antitumor immunity promote immune-mediated bystander killing of KRAS-G12C inhibitor resistant subpopulations, providing a strategy to overcome drug resistance that... 110 0
Reposted by Miriam Molina-ArcasRocio Sancho Lab @labsancho.bsky.social · 12/10/2025www.linkedin.com/posts/paola-... Looking for a PhD? We are offering a project for the 2026 intake at the Crick!linkedin.comBonfanti and Sancho Lab | Dissecting disease-associated pathways and autoimmunity in type 1 diabetes and congenital hyperinsulinism using iPSC-derived beta cells and spatial multi-omics | Paola Bonfan...The 2026 #PhD recruitment at The Francis Crick Institute is now open! We are please to announce an additional opportunity to join our laboratory through a PhD project in collaboration with the Rocio... 055 0
Reposted by Miriam Molina-ArcasTargeting RAS @targetingras.bsky.social · 10/10/2025🎬 #TargetingRAS2025 comes to an end! Three inspiring days of talks, round tables, and networking around the latest advances and challenges in RAS research. 🧬💡 A big thank you to all attendees, speakers, sponsors, partners, and the organizing committee for making this 2nd edition possible. 💙 011 0
Reposted by Miriam Molina-ArcasTargeting RAS @targetingras.bsky.social · 09/10/2025🎥 Day 2 of #TargetingRAS2025 comes to an end! A day filled with great talks, round tables, and outstanding speakers sharing insights on RAS research. 🧬💡 ✨ Tonight: the Symposium Dinner. 👉 Tomorrow: the final day of the symposium. 011 0
Reposted by Miriam Molina-ArcasTargeting RAS @targetingras.bsky.social · 08/10/2025🎥 Day 1 of #TargetingRAS2025 wrapped up! An inspiring start with outstanding talks, great discussions, and valuable scientific exchange on RAS research. Huge thanks to all speakers, attendees & organizers for a successful first day. ✨ Two more days to go—stay tuned! 133 0
Reposted by Miriam Molina-ArcasTargeting RAS @targetingras.bsky.social · 11/08/2025‼️ Last days to submit your abstract for Targeting RAS 2025! 📅 Deadline: August 15 🏆 2 x €250 Molecular Oncology (FEBS) poster prizes Complete your registration at 👉🏼 targetingras.com/registration and upload your abstract now! #TargetingRAS2025 #25anniversaryCIC 101 0
Miriam Molina-Arcas @molinaarcas.bsky.social · 27/06/2025We have spent four great days talking about Small G proteins. Thanks Angeliki Malliri, @ianprior.bsky.social @biochemsoc.bsky.social for the invitation and the organization #BiochemEvent #SGP25 150 0
Miriam Molina-Arcas @molinaarcas.bsky.social · 15/06/2025It was great to see everybody so engaged with the scientific discussions. Even more than with the pool and table football matches #Downwardlab 030 0
Reposted by Miriam Molina-ArcasTargeting RAS @targetingras.bsky.social · 13/05/2025(1/4) 🔗 Science thrives on connections! 🗨️ At the Targeting RAS Symposium 2025, networking opportunities are an essential part of the experience. The programme has been designed in order to propitiate the exchange of ideas between young talent and established researchers. 102 0
Reposted by Miriam Molina-ArcasAmerican Association for Cancer Research (AACR) @theaacr.bsky.social · 28/04/2025At yesterday's opening ceremony, we asked the cancer community to stand together to make their voices heard in support of innovative cancer science and medicine. #CancerResearchSavesLives® #AACR25 15025 0
Reposted by Miriam Molina-ArcasIan Prior @ianprior.bsky.social · 22/04/2025Final week for the early bird deadline for the Small G-protein meeting in Manchester. Talk slots available from submitted abstracts. #SGP25 @BiochemSoc @SmallGTPases Register here: bit.ly/SmallG25bit.lySmall G proteins in cellular signalling and disease 2025 046 0
Reposted by Miriam Molina-ArcasTargeting RAS @targetingras.bsky.social · 04/04/20251/5 🔬 Meet the Organizing Committee for the Targeting RAS Symposium 2025! A distinguished Organizing Committee of leading researchers and experts is shaping an event dedicated to cutting-edge advances in RAS-driven cancers. #TargetingRAS2025 133 0
Reposted by Miriam Molina-ArcasDr Colin Lindsay @drcolinlindsay.bsky.social · 27/03/20251) KRYSTAL-7 update on pembro+adagrasib in 1st line pdl1 >50% nsclc. Tox to navigate but mPFS >27m! Further reinforcing the view that ras orchestrates TME, not just cancer cell intrinsic pathways. Massive congrats to investigators, mirati, bms #ELCC25 065 0
Reposted by Miriam Molina-ArcasDr Colin Lindsay @drcolinlindsay.bsky.social · 25/02/2025Excellent summary of what was a superb meeting on precision medicine for KRAS and the MAP kinase pathway. magazine.eacr.org/highlights-f... Thanks again +++ @helloeacr.bsky.social and @boehringerglobal.bsky.social for the invitation. @mcrcnews.bsky.social @cruk-mi.bsky.socialmagazine.eacr.orgHighlights from the EACR-Boehringer Ingelheim 2025 Conference: Drugging and Regulating the MAP Kinase Pathway - The Cancer ResearcherThe EACR Scientific Officer, Alexandra Boitor, summarises the recent virtaul conference 'EACR Drugging and Regulating the MAP Kinase Pathway'. 063 0
Miriam Molina-Arcas @molinaarcas.bsky.social · 14/02/2025For RAS enthusiasts, register to the 2nd Targeting RAS symposium! Amazing speakers in beautiful Salamanca #RAS #KRAS 011 0
Miriam Molina-Arcas @molinaarcas.bsky.social · 12/02/2025It was a pleasure to speak at the EACR-Boehringer Ingelheim Conference on Drugging and Regulating the MAP Kinase Pathway. Thanks a lot to the organisers for these two days of exciting science @helloeacr.bsky.social 091 0
Reposted by Miriam Molina-ArcasFrancesca Ciccarelli @ciccarellilab.bsky.social · 25/01/2025With Ilaria Malanchi @ila07.bsky.social we will host the #MedicineattheCrick event (13th March at the Crick @crick.ac.uk.) Join world experts to discuss how early mutant cells interact with surrounding niche to maintain homeostasis or start cancer. Free registration! Details in the poster 👇 0258 0
Miriam Molina-Arcas @molinaarcas.bsky.social · 15/12/2024Thanks @iaslc.bsky.social for the invitation to speak at this amazing meeting. Hot Topic Meeting: Tolerance and #Resistance to #TargetedTherapy in #NSCLC. Incredible talks and discussions. #HTTR2024 www.httr2024-iaslc.org/full-programhttr2024-iaslc.orgFull Program - HTTR24 - Hilton DC National Mall The Wharf 000 0
Reposted by Miriam Molina-ArcasAnna Obenauf @obenaufa.bsky.social · 22/11/2024Pls RT: Are you studying the multifaceted MAPK pathway? We would love to hear about your exciting research! Abstract Deadline 👉16.12.2024 for the #virtualmeeting on "Drugging and regulating the #MAPKpathway" organised with @EACRnews with @Boehringer eacr.org/conference/boe…eacr.org 12012 0
Miriam Molina-Arcas @molinaarcas.bsky.social · 22/11/2024Very proud of @pan-anas.bsky.social for passing his PhD viva yesterday. Congratulations Dr Anastasiou! Fantastic job done in the #Downwardlab after recently publishing his PhD work www.nature.com/articles/s41.... @juliandownward.bsky.social @thecrick.bsky.socialnature.comCombining RAS(ON) G12C-selective inhibitor with SHP2 inhibition sensitises lung tumours to immune checkpoint blockade - Nature CommunicationsGDP-bound form of KRASG12C inhibitors have been approved for the treatment of patients with advanced KRASG12C mutant non-small cell lung cancer (NSCLC), however resistance to these drugs is often obse... 060 0