EYA3 promotes evasion of cytotoxic NK cells to enable metastasis, highlighting a therapeutic target in metastatic breast cancer.

Abstract. Cutaneous burn injury in the elderly is associated with poor clinical outcomes and increased pulmonary-related complications. We and others have

Abstract. Burn trauma triggers dysregulated systemic inflammation, leading to multiorgan dysfunction. Respiratory failure often follows burn injury, result

Abstract. Features of the natural life cycle of the budding yeast Saccharomyces cerevisiae were crucial to its domestication as a laboratory experimental m

IntroductionThe presence of micro- and nano-plastics (MNPLs) in the environment has increased significantly in the past decades. However, the direct impact o...

The gut microbiota transforms energy stored as undigestible carbohydrates into a remarkable number of metabolites that fuel intestinal bacterial communities and the host tissue. Colonic epithelial ...

Translation is a highly regulated process that includes three steps: initiation, elongation, and termination. Tremendous efforts have been spent to study the regulation of each translation step. In th...

Protein-based nanomachines drive every cellular process. An explosion of high-resolution structures of multiprotein complexes has improved our understanding of what these machines look like and how th...

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αβ-tubulin is an essential protein that is found in all eukaryotic cells. αβ-tubulins assemble into microtubule polymers that form intracellular transport networks, mitotic and meiotic spindles and pr...

Summary: Rab40 GTPases interact with AMBRA1 and cause its non-degradative ubiquitylation. AMBRA1 regulates cancer cell migration, and RNA sequencing reveals global gene profiles regulated by AMBRA1.

AbstractProtein homeostasis is critical to the survival of multiple myeloma cells. Although this is targeted with proteasome inhibitors, mRNA translation inhibition has not entered trials. Recent work...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Ribosome profiling (Ribo-seq) measures translational regulation and reveals novel or unannotated open reading frames (nuORFs) otherwise difficult to identi

The ability of cancer cells and immune cells cell to dynamically change their phenotype contributes to tumor progression and therapy resistance. This Essay explores the mutual plasticity of various ce...

RNA molecules are localized to subcellular regions through interactions between localization-regulatory cis-elements and trans-acting RNA binding proteins (RBPs). However, the identities of RNAs whose...

Dendritic cells are supplied antigens by other cells such as lymphatic endothelial cells (LEC) at late time points after immunization. Here the authors show antigen archiving is defined by a transcrip...

Abstract. Across cell types and organisms, thousands of RNAs display asymmetric subcellular distributions. Studying this process requires quantifying abund

Phenotype variation is higher in mutants than wild types. Examining a range of mutant severities, this study unexpectedly found that variation decreases in severe conditions. A quadratic trend best fi...

Establishing, maintaining, and removing histone post-translational modifications associated with heterochromatin is critical for shaping genomic structure and function as a cell navigates different st...

Diabetes is an epidemic with increasing incidence across the world. Most individuals who are afflicted by this disease have type 2 diabetes, but there are ma...

imageimageIn Drosophila, degradation of maternal protein ME31B and its cofactors is restricted by the developmental expression profile of the CTLH E3 ligase subunit Muskelin. Muskelin is autoregulated...

The yeast Saccharomyces cerevisiae buds at sites predetermined by cortical landmarks deposited during prior budding. During mating between haploid cells in the lab, external pheromone cues override th...