Sign in

Martial Marbouty

@mmarbout.bsky.social
83 followers 48 following 14 posts

Organizations, structures and dynamics of microbial communities. Phages lover. CNRS researcher. Developer of HiC technics and bioinformatic pipelines applied to metagenomes. Opinions are my own.

PostsRepliesMedia
Martial Marbouty @mmarbout.bsky.social · 30/08/2026
🚨 ‼️ NEW PUBLICATION ‼️ While we start to know a lot about how bacterial genomes are organized in 3D, almost nothing is known about phage genome once it enters a bacterial cell. read the paper here: www.science.org/doi/10.1126/...
science.org
Bacteriophage PAK_P3 genome structuration and dynamics during infection of Pseudomonas aeruginosa reveal specific interaction patterns
While the dynamic changes in genome organization in cellular organisms have been well described, the three-dimensional (3D) folding of phage genomes during the infection of their host is extremely lim...
04422
Reposted by Martial Marbouty
Marie-Eve VAL @val-meve.bsky.social · 04/05/2026
This one means a lot. Our paper, “Large extrachromosomal replicons are widespread across bacterial lineages and show coordinated replication termination and spatial coupling with the chromosome,” is out! doi.org/10.1038/s414...
doi.org
Large extrachromosomal replicons are widespread across bacterial lineages and show coordinated replication termination and spatial coupling with the chromosome - Nature Communications
Bacterial genomes often include extrachromosomal replicons, ranging from small plasmids to chromosome-scale replicons. Here, Czarnecki et al. analyse more than 40,000 complete bacterial genomes and sh...
14833
Martial Marbouty @mmarbout.bsky.social · 17/12/2025
Together, these findings uncover a novel facet of phage–host interactions by showing that a regulated 3D orchestration of phage genome organization takes place during infection. Our study provides the first evidence that such a level of structural dynamics in a phage-bacteria system exist.
020
Martial Marbouty @mmarbout.bsky.social · 17/12/2025
Analyses of interactions patterns between the two genomes demonstrate that phage tends to interact with low active region of host genome suggesting a localization of the phage in the middle of the nucleoid; probably to better hijack host cellular machinery.
120
Martial Marbouty @mmarbout.bsky.social · 17/12/2025
We also characterise phage genomes dynamics that undergo an important decondensation while entering into the cell and a rapid structuration of its early genes cluster potentially involving a NAP-like factor.
100
Martial Marbouty @mmarbout.bsky.social · 17/12/2025
We applied time series HiC and combined it with transcription data to study the dynamic of phage genome from inside its capsid till the end of its infection cycle. Infection leads to a local destructuration of host genome in link with transcription arrest while its global architecture remains.
100
Martial Marbouty @mmarbout.bsky.social · 17/12/2025
💥 alert article 💥 New preprint from the lab !!! 🥳 In this work, we explore the 3D genome architecture of the virulent phage PAK_P3 during its infection cycle in P. Aeruginosa. We unveil a highly dynamic structuration as well as specific interactions patterns. www.biorxiv.org/content/bior...
biorxiv.org
162
Reposted by Martial Marbouty
CNRS Biologie @cnrsbiologie.bsky.social · 07/10/2025
#ResultatScientifique 🔎| Et si les phages, ces virus des bactéries, pouvaient infecter plusieurs espèces à la fois et remodeler l’écologie microbienne ? 🦠 ✍️ Martial Marbouty 📕 @natmicrobiol.nature.com | buff.ly/1R9kqjv
insb.cnrs.fr
Les phages à large spectre, omniprésents dans les écosystèmes
Les phages, les virus des bactéries, représentent les entités génétiques les plus abondantes de notre environnement.
184
Martial Marbouty @mmarbout.bsky.social · 19/09/2025
Thanks Meren !! Coming from you … I am honoured !!
000
Reposted by Martial Marbouty
Romain Koszul @rkoszul.bsky.social · 19/09/2025
New paper! We generated and/or (re)analyzed ~100 #metagenomics Hi-C datasets to provide a comprehensive analysis of bacterial and viral metagenomes across VERY different environments. Congratulations to all authors especially Amaury Bignaud and @mmarbout.bsky.social for the huge work! #metaHiC
096
Martial Marbouty @mmarbout.bsky.social · 19/09/2025
Our work show that phages with a broad host ranges are common across ecosystems. It also highlights the interest of using HiC to study single metagenomic samples. Congrats to all authors !! 🎉
010
Martial Marbouty @mmarbout.bsky.social · 19/09/2025
We then show that among the phages with an assigned host, a substantial proportion of them interact with several, and sometimes distantly related, hosts.
010
Martial Marbouty @mmarbout.bsky.social · 19/09/2025
We have been able to reconstruct numerous good quality viral genomes up to 1Mb from diverse families such as Megaviricetes or Caudoviricetes.
010
Martial Marbouty @mmarbout.bsky.social · 19/09/2025
We then apply our approach on public and newly generated metaHiC datasets (111 in total) from different ecosystems to explore the virosphere of these communities.
000
Martial Marbouty @mmarbout.bsky.social · 19/09/2025
We first used a synthetic community composed of various microorganisms and mobile genetic elements to develop a new version of our MetaTOR pipeline allowing to reconstruct virus genomes and identify their hosts in microbial communities. github.com/koszullab/me...
github.com
GitHub - koszullab/metaTOR: Metagenomic binning based on Hi-C data
Metagenomic binning based on Hi-C data. Contribute to koszullab/metaTOR development by creating an account on GitHub.
020
Martial Marbouty @mmarbout.bsky.social · 19/09/2025
You like phages ? In this publication, we use metaHiC and our new version of the MetaTOR pipeline to challenge the traditional view of phages with a narrow host range. @rkoszul.bsky.social @natmicrobiol.nature.com @cnrs.fr @institutpasteur.bsky.social www.nature.com/articles/s41...
nature.com
Phages with a broad host range are common across ecosystems - Nature Microbiology
Proximity-ligation-based sequencing from 111 samples and 5 environments reveals that a substantial proportion of phages infect multiple species.
67836
Reposted by Martial Marbouty
La Science, CQFD @sciencecqfd.bsky.social · 21/05/2025
Reportage de @celineloozen.bsky.social > Itw de Martial Marbouty, chercheur CNRS au laboratoire Régulation Spatiale des Génomes de l'Institut Pasteur sur l’étude des interactions phages-bactéries tinyurl.com/m9uxwjct #ScienceCQFD
tinyurl.com
Comment détourner les bactériophages à des fins thérapeutiques.
Dans nos organismes, les relations entre bactéries et phages tissent un réseau complexe dont l'analyse ouvre des thérapies innovantes, notamment pour réguler le microbiote intestinal.
033
Reposted by Martial Marbouty
La Science, CQFD @sciencecqfd.bsky.social · 21/05/2025
#Podcast du jour. Virus bactériophages : découverts début XXe s, ils ont été délaissés dans la lutte antibactérienne au profit des antibiotiques. Face à l’antibiorésistance, les bactériophages pourraient-ils faire leur grand retour ? tinyurl.com/yoat4jcu avec Anne Chevallereau et Jérôme Gabard
tinyurl.com
Bactériophages, une épopée thérapeutique
Découverts au début du 20e siècle, les virus bactériophages ont été rapidement délaissés dans la lutte antibactérienne au profit des antibiotiques. Mais face à la crise de l’antibiorésistance, ces "ma...
15117
Martial Marbouty @mmarbout.bsky.social · 27/02/2025
Great science, great discussions, amazing people… a real pleasure to be here !!
010