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Miquéias Lopes-Pacheco

@mlopes0811.bsky.social
59 followers 75 following 82 posts

Brother of a CF warrior (in memoriam) | MS, PhD | Drug Development and Precision Medicine | Respiratory Disease Researcher | Cat lover | Traveler | 40 years.

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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 5h
EN: 🏆 I'm honored to share that, for the sixth consecutive year, I have been recognized among the Top 2% Cited Scientists worldwide, based on the list compiled by Stanford University using Scopus citation data. 👨🏻‍🔬🔬📊💊🫁 👉🏻 doi.org/10.17632/btc...
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Reposted by Miquéias Lopes-Pacheco
Pulmonary & Integrated Molecular Reseach @primrlab.bsky.social · 5h
(1) EN: CFTR modulators have transformed care for people with Cystic Fibrosis (CF). Using high-throughput screening, researchers identified small-molecule correctors and potentiators that target specific defects in CF-causing variants.
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Reposted by Miquéias Lopes-Pacheco
Pulmonary & Integrated Molecular Reseach @primrlab.bsky.social · 07/10/2026
(1) EN: Precision medicine is transforming respiratory care by making it more personalized, moving beyond broad disease labels to understand patients through biomarkers, endotypes, and treatable traits.
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Reposted by Miquéias Lopes-Pacheco
Pulmonary & Integrated Molecular Reseach @primrlab.bsky.social · 06/10/2026
(1) EN: October is Primary Ciliary Dyskinesia (PCD) Awareness Month. PCD is a rare genetic condition in which cilia don’t beat properly, often leading to chronic lung infections, bronchiectasis, and, in some cases, situs inversus. Because testing is limited, diagnosis can take a long time.
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 05/10/2026
EN: I am thrilled to share that Scholarly Index has recognized me among the Top 1000 Scholars in two research topics: 1) Cystic Fibrosis Research Advances — World Rank #56 (2021–2025) and #756 (lifetime) 🧬 2) Neonatal Respiratory Health Research — World Rank #362 (2021–2025) 🚼
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Reposted by Miquéias Lopes-Pacheco
Pulmonary & Integrated Molecular Reseach @primrlab.bsky.social · 05/10/2026
(1) EN: Coffee may support your lung health more than you might expect. A dose-response study found that caffeine in coffee acts as a mild bronchodilator, improving FEV1 in people with asthma, though it is only about 40% as potent as theophylline.
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Reposted by Miquéias Lopes-Pacheco
Pulmonary & Integrated Molecular Reseach @primrlab.bsky.social · 04/10/2026
(1) EN: Coffee breaks are more than downtime; they are welcoming spaces for scientific exchange. In the lab, isolation can breed stagnation; over coffee, failures, early-stage ideas, and doubts become shared puzzles to explore together.
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Reposted by Miquéias Lopes-Pacheco
Pulmonary & Integrated Molecular Reseach @primrlab.bsky.social · 03/10/2026
(1) EN: October is Healthy Lung Month 2026. Our lungs work nonstop… So give them the care they deserve! Quit smoking or vaping, keep your home well-ventilated, stay active, and avoid secondhand smoke.
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Reposted by Miquéias Lopes-Pacheco
Pulmonary & Integrated Molecular Reseach @primrlab.bsky.social · 02/10/2026
(1) EN: Every breath is a gift we often take for granted… until breathing becomes difficult! Today, we celebrate World Oxygen Day (O–2), the unseen element that sustains every cell in our bodies and every heartbeat.
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Reposted by Miquéias Lopes-Pacheco
Pulmonary & Integrated Molecular Reseach @primrlab.bsky.social · 02/10/2026
(1) EN: The definitions of acute respiratory distress syndrome (ARDS) have evolved significantly since 1967, when Ashbaugh first described the syndrome clinically. In 1994, experts established a standard diagnostic approach based on blood oxygen levels.
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 01/10/2026
#tbt to when I received the fantastic news that I was selected as a winner of the 2025 International Journal of Molecular Sciences (IJMS) Young Investigator Award! 👨🏻‍🔬🏆 #IJMS #YoungInvestigator #MolecularMedicine #BiomedicalResearch @mdpiopenaccess.bsky.social www.mdpi.com/journal/ijms...
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Reposted by Miquéias Lopes-Pacheco
Pulmonary & Integrated Molecular Reseach @primrlab.bsky.social · 01/10/2026
(1) EN: In 1989, three Science papers identified the Cystic Fibrosis (CF) gene using complementary approaches: 1) chromosome walking and jumping mapped the locus to chromosome 7; 2) cDNA cloning revealed a ~6,500-nucleotide transcript coding a protein with 2 transmembrane and 2 ATP-binding domains;
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Reposted by Miquéias Lopes-Pacheco
Pulmonary & Integrated Molecular Reseach @primrlab.bsky.social · 30/09/2026
(1) EN: A recent study highlights that, despite decades of progress in reducing chronic respiratory disease (CRD) mortality, the burden remains substantial, with increasing concentration among older people and in certain regions.
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Pulmonary & Integrated Molecular Reseach @primrlab.bsky.social · 29/09/2026
(1) EN: Respiratory diseases are responsible for millions of deaths every year, and their burden is felt across every income group. Deaths from lung cancer and COPD are rising, while lower respiratory infections remain a persistent threat.
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 28/09/2026
I'm pleased to share a new milestone: 3,000 citations according to the @scopus.bsky.social 👨🏻‍🔬✨ #biomedicalresearch #scopus
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 26/09/2026
Our new paper, "Phage Therapy in People with Cystic Fibrosis: A Systematic Review," has been published (a few months ago) in the International Journal of Infectious Diseases 👨🏻‍🔬🦠💊 #PhageTherapy #CysticFibrosis #SystematicReview 🔗 doi.org/10.1016/j.ij...
doi.org
Redirecting
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 15/01/2026
👨🏻‍🔬🧬🫁
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 11/12/2025
Five years later, I remain deeply grateful to Prof. Bruce Stanton for his generous praise of my sole-author paper. For those interested, the publication is available here: doi.org/10.3389/fpha... #tbt #cysticfibrosis #drugdevelopment #precisionmedicine #cftrmodulators
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 08/12/2025
Even having published >70 scientific papers, I actively seek out new concepts to fuel and improve my writing skills. 📝🎖️👨🏻‍🔬
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 24/11/2025
Our new paper has been published: "Chiral Resolution, stereochemical assignment and correction of a cystic fibrosis-causing variant of Aryl-Triazolyl-methanol derivative" in Journal of Molecular Strucuture 🧑‍🔬🧬💊 #medicinalchemistry #drugdevelopment #cysticfibrosis doi.org/10.1016/j.mo...
doi.org
Redirecting
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 13/11/2025
🏆 I am honored to share that ScholarGPS has recognized me as a Highly Ranked Scholar (analysis of Prior Five Years) in three specialties: Precision Medicine (for the second year running), Cystic Fibrosis, and Fibrosis. 👨🏻‍🔬📚🧬🔬🫁 #biomedicalresearch #cysticfibrosis #precisionmedicine
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 04/11/2025
Our new paper has been published: "Extracellular Vesicles: Multimodal Tools for Diagnosis, Prognosis, and Therapy in Respiratory Diseases" in Expert Review in Molecular Medicine | @universitypress.cambridge.org 🧑‍🔬🧬🫁 #extracellularvesicles #lungdisease #biomarker #therapydevelopment bit.ly/4nBXfCG
cambridge.org
Extracellular Vesicles: Multimodal Tools for Diagnosis, Prognosis, and Therapy in Respiratory Diseases | Expert Reviews in Molecular Medicine | Cambridge Core
Extracellular Vesicles: Multimodal Tools for Diagnosis, Prognosis, and Therapy in Respiratory Diseases - Volume 27
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 29/10/2025
Our new paper has been published: "Extracellular vesicles from mesenchymal stromal cells as a promising therapy for ARDS: a systematic review of preclinical studies" in @frontiersin.bsky.social in Medicine 👨‍🔬📚 #extracellularvesicles #ards #lungdisease #therapydevelopment doi.org/10.3389/fmed...
doi.org
Frontiers | Extracellular vesicles from mesenchymal stromal cells as a promising therapy for ARDS: a systematic review of preclinical studies
IntroductionMesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) have emerged as a promising cell-free therapeutic strategy for acute respirator...
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 18/10/2025
#fbf #cysticfibrosis
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 22/09/2025
🏆 I'm honored to share that, for the fifth consecutive year, I have been recognized among the Top 2% Cited Scientists worldwide, based on the list compiled by Stanford University using Scopus citation data. 👨🏻‍🔬🔬📊💊🫁 👉🏻 doi.org/10.17632/btc... #biomedicalresearch #biochemistry #cysticfibrosis
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 22/08/2025
I shared yesterday some work I have been conducting over the last few years... 🧑🏻‍🔬🧬🫁📚 #cysticfibrosis #cftrbiology #drugdevelopment #lifeinscience @emory-choa-cfair.bsky.social
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 18/08/2025
Our new paper has been published: "Building Lay Society Knowledge and Education for Health Technology Assessment and Policy Engagement: Case of CFTR Modulator Access in Brazil" in Healthcare @mdpiopenaccess.bsky.social 👨‍🔬📚 #cysticfibrosis #healthpolicy #advocacy www.mdpi.com/2227-9032/13...
mdpi.com
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 15/08/2025
Highlights of 20 years of training and research... 📚🧑🏻‍🔬 #fbf #lifeinscience #phdjourney #cysticfibrosis
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 11/08/2025
💜💚 unidospelavida.org.br/irmao-e-pesq...
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 31/07/2025
Ending the month with a new milestone: 2500 citations 🧑🏻‍🔬 #scopus
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 28/07/2025
Our new paper has been published: "Advancing cystic fibrosis treatment: investigational agents on the horizon" in Expert Opinion in Pharmacotherapy 👨‍🔬🧬🔬🧫 💊 #cysticfibrosis #CFTR #CFTRmodulator #noveltherapeutics #precisionmedicine #pharmacology #genetherapy www.tandfonline.com/doi/full/10....
tandfonline.com
Advancing cystic fibrosis treatment: investigational agents on the horizon
Cystic fibrosis (CF) treatment has been transformed by CF transmembrane conductance regulator (CFTR) modulator therapies, yet significant gaps remain for those with non-responsive or modestly respo...
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 20/06/2025
First Cystic Fibrosis Conference I attended... 🧑🏻‍🔬🧬🔬 #fbf #2008 #oldbutgold #cysticfibrosis
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 01/06/2025
💡Massive DNA sequencing effort reveals how colonization shaped Brazil’s genetic diversity | Science | AAAS www.science.org/content/arti...
science.org
Massive DNA sequencing effort reveals how colonization shaped Brazil’s genetic diversity
New study identifies thousands of new variants related to diseases
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 29/05/2025
Being a CF brother and scientist has been a journey... not a fair one in many ways, but I always have this quote in mind: "It is not how much we do, but how much love we put in the doing..." 💜 #cysticfibrosis #CFAwarenessMonth #addingtomorrows #justbreathe #CFwarrior #dumspirospero
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 22/05/2025
"Each breath is a step closer to our dreams..." 💜 #cysticfibrosis #CFAwarenessMonth #CFAwareness #lifeinscience
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 20/05/2025
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Reposted by Miquéias Lopes-Pacheco
CF-AIR @emory-choa-cfair.bsky.social · 19/05/2025
CF-AIR, CF@LANTA, and the CF Care Team had a great time on Saturday, May 17th supporting the Cystic Fibrosis Foundation's Great Strides Atlanta event! 💙
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 15/05/2025
In the week of @cffgeorgiachapter Great Strides, we wear #65roses to celebrate #CFAwarenessMonth 🌹💜 #cysticfibrosis #cfawareness #fight4cure #justbreathe
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 08/05/2025
Another Thursday celebrating the #CFAwarenessMonth 💜 #cysticfibrosis is part of who we are -- not the limit of who we can be! #fight4cure #crossoutcf #cfawareness
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 08/05/2025
🧬✍🏻 #cysticfibrosis #cfawareness #inkonskin #lifeinscience #cfawarenessmonth #cftr
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 01/05/2025
It has been a journey... Thanks, @emilysentourage.bsky.social for including me in the #CFAwarenessMonth campaign this year! 💜 #cysticfibrosis #fight4cure #cysticfibrosisawareness #crossoutcf www.emilysentourage.org/the-cf-broth...
emilysentourage.org
The CF Brother Who Became a CF Scientist
During CF Awareness Month, Emily’s Entourage invites members of the cystic fibrosis (CF) community to share their stories. Today’s blog post highlights the story of Miquéias Lopes Pacheco, PhD, a brot...
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 01/05/2025
Here we are to celebrate another #CFAwarenessMonth as a proud brother of a #CFwarrior 🦾🧬 #cysticfibrosis #fight4cure #cfawareness #crossoutcf
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 21/04/2025
“People who identify as being more empathic not only tend to be more creative, but may be more productive with their creativity, too” 💭 greatergood.berkeley.edu/article/item...
greatergood.berkeley.edu
Can Empathy Help You Be More Creative?
A new study suggests that people who are good at seeing things from others' perspectives are more likely to be creative in everyday life.
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 20/04/2025
www.nature.com/articles/d41...
nature.com
How do I explain the publication gap I ended up with after a hostile manager?
A poor working relationship with a supervisor or manager can result in lost opportunities, creating an unexplained gap in an early-career researcher’s publication record.
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 14/04/2025
Our new paper has been published: "Recent developments in cystic fibrosis drug discovery: where are we today?" in Expert Opinion in Drug Discovery Taylor & Francis 👨‍🔬🧬🔬🧫 💊 #cysticfibrosis #CFTR #CFTRmodulator #noveltherapeutics #precisionmedicine #multiomics www.tandfonline.com/eprint/RNWZS...
tandfonline.com
Recent developments in cystic fibrosis drug discovery: where are we today?
The advent of variant-specific disease-modifying drugs into clinical practice has provided remarkable benefits for people with cystic fibrosis (PwCF), a multi-organ life-limiting inherited disease....
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 13/04/2025
13 years (and counting...) since my M.S. thesis defense. 🧑🏻‍🔬🫁 #lifeinscience #masterthesis #respiratorydiseaseresearch #silicosis #celltherapy
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 11/04/2025
💭
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 10/04/2025
#tbt #sciencefacts In this #experimentalstudy, we demonstrated that certain #CFTRmodulators rescue misfolded variants in #ABCA4, a protein involved in macular degeneration. These may represent promising #therapeutics for #Stargard #eyedisease 🧑🏻‍🔬🧬💊 #drugdevelopment pubmed.ncbi.nlm.nih.gov/26092729/
pubmed.ncbi.nlm.nih.gov
Rescuing Trafficking Mutants of the ATP-binding Cassette Protein, ABCA4, with Small Molecule Correctors as a Treatment for Stargardt Eye Disease - PubMed
Stargardt disease is the most common form of early onset macular degeneration. Mutations in ABCA4, a member of the ATP-binding cassette (ABC) family, are associated with Stargardt disease. Here, we ha...
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 07/04/2025
🧑🏻‍🔬✨ #scholargps #precisionmedicine #lifeinscience
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Miquéias Lopes-Pacheco @mlopes0811.bsky.social · 04/04/2025
#fbf #sciencefacts This #clinicalstudy was published in 2015 and demonstrated that infusion of bone marrow mononuclear cells via bronchoscopy is safe and well tolerated in patients with #silicosis 🧑‍🔬🔬🫁📊 #celltherapy #lungdisease #therapydevelopment pubmed.ncbi.nlm.nih.gov/26059242/
pubmed.ncbi.nlm.nih.gov
Pilot safety study of intrabronchial instillation of bone marrow-derived mononuclear cells in patients with silicosis - PubMed
NCT01239862 Date of Registration: November 10, 2010.
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