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Marco Lolaico

@mlolaico.bsky.social
82 followers 43 following 58 posts

Writing about AI-based protein design, DNA nanotech, molecular programming and more @ plentyofroom.beehiiv.com

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Marco Lolaico @mlolaico.bsky.social · 17/09/2026
This is where AI protein design gets interesting: exploring structures that evolution never built. plentyofroom.beehiiv.com/p/ai-designe... Read the full issue →
plentyofroom.beehiiv.com
AI-Designed RNA Shuttles: Synthetic Protein Vehicles for Drug Delivery
AI-designed RNA shuttles combine synthetic proteins with membrane modules for targeted RNA delivery, advancing medicine beyond current lipid nanoparticle limitations.
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Marco Lolaico @mlolaico.bsky.social · 17/09/2026
Instead of copying the icosahedral symmetry common in natural viral capsids, the researchers explore non-natural geometries. Their best design outperforms the other delivery systems they test, including lipid nanoparticles!
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Marco Lolaico @mlolaico.bsky.social · 17/09/2026
After screening more than 100 designs, they identify STV C8, a synthetic delivery particle that can package different RNAs, target specific cells, and deliver functional cargo.
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Marco Lolaico @mlolaico.bsky.social · 17/09/2026
So why not design something new? In a new study, researchers combine natural proteins with AI-designed protein assemblies to build synthetic transfer vehicles, or STVs.
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Marco Lolaico @mlolaico.bsky.social · 17/09/2026
Viruses are exceptionally good at delivering genetic material. But they're optimized for their own biology, not for delivering therapeutic RNA!
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Marco Lolaico @mlolaico.bsky.social · 17/09/2026
🧬"What if we could design RNA delivery vehicles without copying the architecture of natural viruses?" RNA therapeutics can do almost anything, but getting RNA into the right cells is still a major challenge. 🧪
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Marco Lolaico @mlolaico.bsky.social · 09/11/2025
It's a super cool work! And thank for sharing 😁
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Marco Lolaico @mlolaico.bsky.social · 05/09/2025
Such a cool work! And turning a weakness of DNA origami into a strength is super smart 😁🧪
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Marco Lolaico @mlolaico.bsky.social · 29/08/2025
Cool work! Plastics from DNA? Funny idea 😎🧪
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Marco Lolaico @mlolaico.bsky.social · 08/08/2025
Protein emulation with a silly name? Yes please 😎🧪
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Marco Lolaico @mlolaico.bsky.social · 27/07/2025
Don't miss this cool work! 🧪
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Marco Lolaico @mlolaico.bsky.social · 21/07/2025
Great work! 😎🧪
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Marco Lolaico @mlolaico.bsky.social · 13/07/2025
The perfect article for your Sunday 😎🧪
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Marco Lolaico @mlolaico.bsky.social · 06/07/2025
Don't miss this amazing work! 🧪
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Marco Lolaico @mlolaico.bsky.social · 29/06/2025
Amazing work! 🧪
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Marco Lolaico @mlolaico.bsky.social · 06/06/2025
Looking for some cool research? Don't miss this one then! 🧪
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Marco Lolaico @mlolaico.bsky.social · 30/05/2025
Super cool work! 😎 🧪
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Marco Lolaico @mlolaico.bsky.social · 25/05/2025
🧪
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Marco Lolaico @mlolaico.bsky.social · 23/05/2025
Are you looking for something to read? Here you go! AI has shown potential for protein design (looking at you, Alphafold). But is it possible to leverage it to create functional RNA? Well, from now yes! 🧪🖥️🧬 Subscribe to get more like this 👉 plentyofroom.beehiiv.com/p/ai-rna-des... #AI #biotech
plentyofroom.beehiiv.com
AI RNA Design: Generating Functional Molecules with Machine Learning!
AI RNA design: Advanced machine learning techniques create functional RNA molecules, from CRISPR guides to innovative toehold switches.
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Marco Lolaico @mlolaico.bsky.social · 18/05/2025
Looking for some weekend reading? 🧪
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Marco Lolaico @mlolaico.bsky.social · 16/05/2025
Amazing work bridging top-down and bottom-up nanofabrication! 🧪
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Marco Lolaico @mlolaico.bsky.social · 10/05/2025
Thank you very much for your explanation! I'm not too much into spatial transcriptomics, so your input is great! And yeah, I have also seen very limited adoption, looking at the methods it looks also very complicated.
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Marco Lolaico @mlolaico.bsky.social · 10/05/2025
Ahahah probably the right choice! I think it's a cool idea, definitely years away from any real use. What is your opinion?
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Marco Lolaico @mlolaico.bsky.social · 09/05/2025
Should I get rid of my microscope? DNA microscopy lets you image your sample using only sequencing, now in 3D! 🧪 Super cool work from University of Chicago. Subscribe today! #DNA #biotech #imaging #microscopy plentyofroom.beehiiv.com/p/dna-micros...
plentyofroom.beehiiv.com
DNA Microscopy: Seeing by Sequencing Revolution!
DNA microscopy revolutionizes imaging: sequencing techniques create unprecedented 3D cellular visualization, transforming how we image biological samples.
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Marco Lolaico @mlolaico.bsky.social · 08/05/2025
Are you wondering if AI will steal your job? I don't know about that, but it can create new enzymes! 🧪 Subscribe to get more like this in your inbox! #science #AI
plentyofroom.beehiiv.com
AI Enzyme Design: Powering Molecular Catalysis with Cutting-Edge AI!
AI revolutionizes enzyme design, using machine learning to create innovative biological catalysts for complex reactions and molecular engineering breakthroughs.
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Marco Lolaico @mlolaico.bsky.social · 02/05/2025
That's the spirit!
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Marco Lolaico @mlolaico.bsky.social · 02/05/2025
Amazing work! Had to learn a lot to cover this 😂😅🧪
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Marco Lolaico @mlolaico.bsky.social · 27/04/2025
Looking for something to read today? Maybe you're also traveling to a conference? Here you go then 😎🧪
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Marco Lolaico @mlolaico.bsky.social · 25/04/2025
Great paper! And I did my best to summarise it as well 🧪
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Marco Lolaico @mlolaico.bsky.social · 22/04/2025
Amazing science 🧪
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Reposted by Marco Lolaico
Plenty of Room - Newsletter @plenty-of-room.bsky.social · 21/04/2025
This will always be my favourite 🧪 #science #sciencehumor #humor
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Marco Lolaico @mlolaico.bsky.social · 17/04/2025
Amazing work out of my "neighbours" at @dtu.dk 😎🧪🧬🖥️
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Reposted by Marco Lolaico
David Blanchflower BSc @davidbflower.bsky.social · 16/04/2025
Colossal squid filmed in ocean for the first time. 🧪 www.bbc.co.uk/news/article...
bbc.co.uk
Colossal squid filmed by scientists for first time in ocean
Stunned scientists say the extremely rare squid can weigh up to 500kg (1,100lb).
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Marco Lolaico @mlolaico.bsky.social · 16/04/2025
Why not put more DNA in your cells? 🧪🖥️🧬
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Marco Lolaico @mlolaico.bsky.social · 15/04/2025
🧪
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Marco Lolaico @mlolaico.bsky.social · 12/04/2025
Are you looking for something cool to read this weekend? Don't miss this then! 😎🧬🖥️🧪
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Reposted by Marco Lolaico
Plenty of Room - Newsletter @plenty-of-room.bsky.social · 11/04/2025
New antibiotics just dropped 😎🧬🖥️🧪
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Marco Lolaico @mlolaico.bsky.social · 10/04/2025
New antibiotics? Yes please! 🧬🖥️🧪
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Marco Lolaico @mlolaico.bsky.social · 05/04/2025
Don't miss this super cool paper 😎🧬🖥️🧪
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Marco Lolaico @mlolaico.bsky.social · 03/04/2025
Amazing paper! It was a great read! 🧪🖥️ 🧬
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Marco Lolaico @mlolaico.bsky.social · 02/04/2025
🧪 🖥️ 🧬
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Marco Lolaico @mlolaico.bsky.social · 31/03/2025
Amazing! 🧪
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Marco Lolaico @mlolaico.bsky.social · 30/03/2025
Exciting research! 🧪 🖥️ 🧬
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Marco Lolaico @mlolaico.bsky.social · 27/03/2025
RNA origami cytoskeletons? Yes please 😎🧪🖥️🧬
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Marco Lolaico @mlolaico.bsky.social · 23/03/2025
Did you miss this issue? It's a cool one 😎🧬🖥️🧪
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Marco Lolaico @mlolaico.bsky.social · 20/03/2025
Amazing work! A new issue and a short thread 😎🧪🖥️🧬
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Marco Lolaico @mlolaico.bsky.social · 18/03/2025
Cool image for a cool paper 😎🧬🖥️🧪
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Reposted by Marco Lolaico
Erik Poppleton @poppleton.phd · 17/03/2025
In the latest from @kgoepfrich.bsky.social’s group, led by the relentless @tranmai.bsky.social, we expressed RNA origami “cytoskeletons” in vesicles! We were fascinated that small changes in design led to divergent results. Future potential for directed evolution?! 🧬🧪 www.nature.com/articles/s41...
nature.com
Genetic encoding and expression of RNA origami cytoskeletons in synthetic cells - Nature Nanotechnology
This study introduces RNA origami nanotubes as self-assembling cytoskeleton mimics for synthetic cells. Expressed in vesicles from DNA templates, these RNA structures reach micrometre lengths, deform ...
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Marco Lolaico @mlolaico.bsky.social · 13/03/2025
Exciting paper! 🧬 🖥️ 🧪
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Marco Lolaico @mlolaico.bsky.social · 10/03/2025
Such a cool paper! 🖥️🧬🧪
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