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Mehrdad Kashefi

@mkashefi.bsky.social
265 followers 405 following 37 posts

mkashefi.com

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Mehrdad Kashefi @mkashefi.bsky.social · 24/09/2026
Congrats, Blake. Well deserved.
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Mehrdad Kashefi @mkashefi.bsky.social · 13/08/2026
Happy birthday, Doug!
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Andrew Pruszynski @andpru.bsky.social · 27/07/2026
We're hiring! Postdoc position to study the neural control of reaching using high-density multi-area electrophysiology. 5 years of funding, great collaborative environment. Please share with anyone who may be interested. For details, see: docs.google.com/document/d/1...
docs.google.com
Pruszynski Postdoc 2026
Postdoctoral Researcher, Control Policies in the Primate Motor Circuit Pruszynski Lab @ Sensorimotor Superlab​ The Pruszynski Laboratory at Western University is seeking a postdoctoral researcher to j...
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Britton Sauerbrei @brittonsauerbrei.bsky.social · 30/06/2026
1/N Excited to share a major update to this work, which includes (1) identification of a thalamocortical communication subspace, (2) cortical lesions which induce selective behavioral deficits, and (3) extraction of cortical readouts by EMG decoding. www.biorxiv.org/content/10.1... Thread:
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Jonathan A. Michaels @jonathanamichaels.bsky.social · 17/06/2026
The Neural Control & Computation Lab is recruiting a Postdoctoral Fellow to investigate the neural basis of learning, flexible neural computation, and skilled movement control using large-scale electrophysiology from single-neuron populations in non-human primates 🧠🐒 www.ncclab.ca/join-the-lab
ncclab.ca
Join the Lab — neural control & computation lab
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Trends in Cognitive Sciences @cp-trendscognsci.bsky.social · 15/06/2026
Online planning of sequential actions Review by Jörn Diedrichsen (@diedrichsenjorn.bsky.social), Mehrdad Kashefi (@mkashefi.bsky.social), Amin Nazerzadeh, & J. Andrew Pruszynski (@andpru.bsky.social) tinyurl.com/2p9nbnbx
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Mehrdad Kashefi @mkashefi.bsky.social · 12/06/2026
This is amazing!
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Jonathan A. Michaels @jonathanamichaels.bsky.social · 12/06/2026
Many of the scientific questions we're interested in tackling require studying learning over long periods of time across the brain. This is challenging – which is why we're excited to say we've been developing a system for chronic wireless recording using long Neuropixels probes in macaque monkeys.
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Andrew Pruszynski @andpru.bsky.social · 10/06/2026
Natural behavior unfolds as a continuous stream of actions. Because these actions often occur in rapid succession, the brain must prepare multiple future actions while the current action is being executed. Our TICS piece explores how this works. www.sciencedirect.com/science/arti...
sciencedirect.com
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Mehrdad Kashefi @mkashefi.bsky.social · 20/05/2026
Best use case of AI so far!
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Mehrdad Kashefi @mkashefi.bsky.social · 15/05/2026
Fantastic work!
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Mehrdad Kashefi @mkashefi.bsky.social · 14/05/2026
Seems like seaborn really hates jet colormap!
In seaborn source code, using jet colormap raises an error which says: No with commented text # paternalism.
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Mehrdad Kashefi @mkashefi.bsky.social · 11/05/2026
Sorry to hear this, my condolences Ravi.
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Andrew Pruszynski @andpru.bsky.social · 06/05/2026
M1 after a few months away ... never gets old. @arminpanjehpour.bsky.social @mkashefi.bsky.social
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Andrew Pruszynski @andpru.bsky.social · 09/04/2026
A fun Q and A that @mkashefi.bsky.social and I contributed to for @natcomms.nature.com along with Friston, @annechurchland.bsky.social, and others. www.nature.com/articles/s41...
nature.com
Open questions in elucidating neural mechanisms underlying sensory-guided motor control - Nature Communications
Sensory feedback is needed to dynamically adjust motor behaviors as we interact with the world, and understanding sensory-guided motor control could be beneficial in guiding future therapeutic strategies for patients suffering from spinal cord injury or other neurological diseases. To explore some of the open questions in this topic, we spoke with several experts in the field: Professor Karl Friston (UCL); Dr. Andrew Pruszynski and Dr. Mehrdad Kashefi (Western University, Canada); Professor Fan Wang and Dr. Kyle Severson (MIT, USA); and Professor Anne Churchland and Dr. Felicia Davatolhagh (UCLA, USA). We discuss some of the main theories of sensory-motor integration, some of the challenges and open questions in this field, and exciting future directions, including neurorehabilitation.
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Jonathan A. Michaels @jonathanamichaels.bsky.social · 30/01/2026
While humans spontaneously dance to a beat, the evolutionary origins of this ability remain debated. Behavioral work has shown that primates can move to auditory rhythms after training. Our question was: How does this association emerge in the brain? www.biorxiv.org/content/10....
biorxiv.org
Reward-driven emergence of auditory pattern encoding in the primate motor system
The ability to anticipate rhythmic patterns is fundamental to human experience, enabling music appreciation, speech comprehension, and dancing in sync to music. How the brain learns to use acoustic information to guide motor behavior remains a key question whose neural underpinnings and evolutionary origins are debated, especially in non-human primates. To understand how brain areas involved in motor control naively respond to predictable tone patterns, we recorded large single neuron populations across primary somatosensory (S1), primary motor (M1), dorsal premotor (PMd), supplementary motor (SMA), pre-supplementary motor (preSMA) cortices, globus pallidus interna (GPi), and medial geniculate body (MGB) of a rhesus monkey. During passive listening (Experiment 1) with a reward only at the end of each trial, primarily the MGB, not motor areas, responded to the auditory tone patterns, ruling out the spontaneous entrainment of motor activity to auditory patterns. Almost all areas robustly
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Paul Gribble 🇨🇦 @gribblelab.org · 19/12/2025
This week's sensorimotor superlab reading list is out superlab.ca/posts/2025-12-19-list31… @andpru.bsky.social @diedrichsenjorn.bsky.social @gribblelab.org #neuroskyence #psychscisky #Sensorimotor
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Paul Gribble 🇨🇦 @gribblelab.org · 17/12/2025
Are you interested in a MSc/PhD in human sensorimotor neuroscience? Learn to design experiments, analyze data, read & write papers, present at conferences, & work with a vibrant group of students & faculty in a world-class research environment. #neuroskyence #psychscisky gribblelab.org/join.html
gribblelab.org
Paul Gribble PhD
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arminpanjehpour.bsky.social @arminpanjehpour.bsky.social · 13/11/2025
0/7 Excited to 📢 that our (@mkashefi.bsky.social @diedrichsenjorn.bsky.social @andpru.bsky.social) new preprint on sequence preparation and its effect on reaction time is now up: www.biorxiv.org/content/10.1... Please get in touch if there is anything you'd like to discuss! Brief summary 🧵👇
biorxiv.org
Sequence preparation is not always associated with a reaction time cost
The extent to which a sequence of movements is prepared before initiating the first movement is a longstanding question in motor neuroscience. The observation that reaction time (RT) increases for lon...
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Mehrdad Kashefi @mkashefi.bsky.social · 15/11/2025
Thanks Jon!
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Jonathan A. Michaels @jonathanamichaels.bsky.social · 29/10/2025
Thrilled that our paper is out today in Nature! www.nature.com/articles/s4...
nature.com
Sensory expectations shape neural population dynamics in motor circuits
Nature - Experiments with human volunteers and macaques show that expectations produced by probabilistic cueing of future sensory inputs shape motor circuit dynamics in order to increase the...
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Jonathan A. Michaels @jonathanamichaels.bsky.social · 02/10/2025
The neural control & computation lab is recruiting! If you're interested in using large-scale neural population recordings to study how the brain learns to produce complex and flexible behaviours, please get in touch. www.ncclab.ca
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Paul Gribble 🇨🇦 @gribblelab.org · 12/09/2025
This week's sensorimotor superlab reading list is out superlab.ca/posts/2025-09-12-list30… @andpru.bsky.social @diedrichsenjorn.bsky.social @gribblelab.org #neuroskyence #psychscisky #Sensorimotor
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Jörn Diedrichsen @diedrichsenjorn.bsky.social · 10/09/2025
Variance partitioning is used to quantify the overlap of two models. Over the years, I have found that this can be a very confusing and misleading concept. So we finally we decided to write a short blog to explain why. @martinhebart.bsky.social @gallantlab.org diedrichsenlab.org/BrainDataSci...
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Sam McDougle @actlab.bsky.social · 08/09/2025
New preprint from the lab! 🧠 Led by Juliana Trach, w/ Sophia Ou Using fMRI, we discovered evidence for time-sensitive reward prediction errors (RPEs) in the human cerebellum. Builds on, and extends, recent work in both rodents and NHPs
figure showing cerebellar RPE responses
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Jörn Diedrichsen @diedrichsenjorn.bsky.social · 08/09/2025
Exited to share tomorrow new updates on trying to figure out how the neocortex and cerebellum talk to each other. Work by @carobellum.bsky.social, Ali Shabazi, and others in the lab!
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Mehrdad Kashefi @mkashefi.bsky.social · 06/09/2025
Thanks Josh!
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Mehrdad Kashefi @mkashefi.bsky.social · 06/09/2025
Thanks Mahdiyar!
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Mehrdad Kashefi @mkashefi.bsky.social · 06/09/2025
Thanks Harrison!
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Mehrdad Kashefi @mkashefi.bsky.social · 06/09/2025
Thanks for reading 🙏 The paper also covers recordings from SMA, pre-SMA, dlPFC & GPi. Full details here ⬇️ www.biorxiv.org/content/10.1... 10/10
biorxiv.org
Compositional neural dynamics during reaching
The complex mechanics of the arm make the neural control of reaching inherently posture dependent. Because previous reaching studies confound reach direction with final posture, it remains unknown how...
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Mehrdad Kashefi @mkashefi.bsky.social · 06/09/2025
Conclusion: Motor cortex dynamics are compositional. They simultaneously: - generate movement - maintain an internal representation of posture - track task progress 9/10
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Mehrdad Kashefi @mkashefi.bsky.social · 06/09/2025
Modeling: Using modular RNNs, we asked what’s required for this compositional structure to emerge. It turns out this solution is common whenever the effector is complex enough to demand posture-dependent control policies. 8/10
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Mehrdad Kashefi @mkashefi.bsky.social · 06/09/2025
3️⃣ A condition-independent shift dimension: a trajectory reflecting trial progression, unfolding similarly across all movements, regardless of direction or posture. 7/10
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Mehrdad Kashefi @mkashefi.bsky.social · 06/09/2025
2️⃣ Rotational dynamics: transitions linking posture-specific fixed points.These rotations were systematic—similar rotations produced similar reach directions—and their projection continuously updated posture. 6/10
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Mehrdad Kashefi @mkashefi.bsky.social · 06/09/2025
Key finding: High-density recordings from M1 & PMd revealed a compositional neural geometry with 3 components. 1️⃣ A posture subspace: fixed points for each target, visited whenever the arm rested at that location before or after a reach. 5/10
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Mehrdad Kashefi @mkashefi.bsky.social · 06/09/2025
Our approach: We trained monkeys to reach between all pairs of 5 targets. Each target was a start point on some trials and an end point on others. This design let us dissociate posture representations from movement dynamics. 4/10
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Mehrdad Kashefi @mkashefi.bsky.social · 06/09/2025
Why this problem exists: Most insights come from center-out tasks, where all movements start from one spot. Here, reach direction and final posture are always correlated—making it impossible to separate movement dynamics from posture encoding. 3/10
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Mehrdad Kashefi @mkashefi.bsky.social · 06/09/2025
The problem: Moving your arm to grab coffee requires different muscle commands depending on where your arm starts. We know the brain must incorporate posture when planning movement—but how neural dynamics achieve this remains unclear. 2/10
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Mehrdad Kashefi @mkashefi.bsky.social · 06/09/2025
Excited to share my latest work with @jonathanamichaels.bsky.social @diedrichsenjorn.bsky.social & @andpru.bsky.social! We asked: How does the motor cortex account for arm posture when generating movement? Paper 👉 www.biorxiv.org/content/10.1... 1/10
biorxiv.org
Compositional neural dynamics during reaching
The complex mechanics of the arm make the neural control of reaching inherently posture dependent. Because previous reaching studies confound reach direction with final posture, it remains unknown how...
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Mehrdad Kashefi @mkashefi.bsky.social · 09/07/2025
Thanks! This is highly relevant to our work.
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Mehrdad Kashefi @mkashefi.bsky.social · 08/07/2025
If this doesn't solve the issue send me an email. Happy to chat more about it!
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Mehrdad Kashefi @mkashefi.bsky.social · 08/07/2025
If that were the case, I would expect this representation to transfer across effectors—especially when the visual sequence remains identical. However, this isn’t what we observe in our data (see Experiment 2 in the paper).
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Mehrdad Kashefi @mkashefi.bsky.social · 08/07/2025
Hi Alfred Nobel! Thanks for your interest! If I understand you correctly, you're suggesting that participants might form a purely cognitive representation of the sequence "shape."
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Sebastian Lehmann @lehmannsj.bsky.social · 29/04/2025
We're excited to share our new paper: “cTBS of prefrontal cortex in the behaving macaque: no evidence for within-target inhibition or cross-hemisphere disinhibition of neural activity” tinyurl.com/cTBSPFCNHP w/ @brian-corneil.bsky.social What did we find? Mostly... what we didn’t! 🧵
tinyurl.com
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Mehrdad Kashefi @mkashefi.bsky.social · 26/04/2025
✋
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Mehrdad Kashefi @mkashefi.bsky.social · 27/03/2025
Heading to #cosyne2025 ? We're presenting new data exploring the geometry of neural dynamics in M1, PMd, PFC, SMA, and GPi during reaching movements with varying start locations, directions, and extents. Find me at Poster Session 3-091 — or anytime before or after!
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Andrew Pruszynski @andpru.bsky.social · 24/03/2025
Going to #Cosyne2025? Check out two posters from the lab, presented by @jonathanamichaels.bsky.social and @mkashefi.bsky.social.
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Sam McDougle @actlab.bsky.social · 24/01/2025
New lab paper out now in JEP:G! From Juliana Trach, @mdebettencourt.bsky.social , @angelaradulescu.bsky.social , and myself. "Rewards Transiently and Automatically Enhance Sustained Attention." t.co/r72fZRn3Nh 👇
task figure showing combined attention and RL task
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Mehrdad Kashefi @mkashefi.bsky.social · 27/12/2024
Our paradigm enables a clear dissociation between the "what" and "how" components of motor sequence learning and provides compelling evidence for the development of effector-specific sequence representations that guide optimal movement execution. 10/n
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Mehrdad Kashefi @mkashefi.bsky.social · 27/12/2024
These results show a clear sequence-specific learning that goes beyond predicting the next movement. In two follow-up experiments we show that the learned sequence representations are effector-specific and encode contextual information of four movements or longer. 9/n
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