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mitenjain.bsky.social

@mitenjain.bsky.social
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Adrien Leger @adrienleger.bsky.social · 28/11/2024
As mentioned above this is still very early R&D work, not ready for release yet. We are generating more data and @stoibs11.bsky.social's team has got plenty of ML magic tricks to significantly improve the performance of the models.
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Reposted by @mitenjain.bsky.social
Adrien Leger @adrienleger.bsky.social · 28/11/2024
We have been busing working on models to detect all 2'Ome-RNA modified nucleotides on top of PseudoU, m6A, m5C and Inosine using @nanoporetech.com direct RNA sequencing. This is still very preliminary but here are a few examples of what it looks like on Human #rRNA prepared with standard lib prep 🤩
Selected areas of Human rRNAs showing modification calls in IGV. Samples sequenced by ONT direct RNA sequencing with experimental Remora models calling m6A, m5C, PseudoU, and all 4 2'Ome modifications.
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Reposted by @mitenjain.bsky.social
Oxford Nanopore @nanoporetech.com · 27/11/2024
We are proud to announce a collaboration with UK Biobank to create the world’s first large-scale #epigenetic dataset of 50k participants. The dataset will unlock crucial insights into how #epigenetics drives disease & the breakthroughs to treat them. Read more: nanoporetech.com/news/oxford-...
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Reposted by @mitenjain.bsky.social
Matt Loose @minomatt.bsky.social · 28/11/2024
This is worth looking at. Trying some genomes we have assembled with earlier versions of hifiasm, hifiasm plus herro and then this new version of hifiasm. The early assembly results suggest that now hifiasm alone is equivalent to what we got with herro but with less compute!
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mitenjain.bsky.social @mitenjain.bsky.social · 14/09/2023
Thank you @theoreticalfun.bsky.social and @danrdanny.bsky.social!
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