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Sebastian Shaw

@millseba.bsky.social
240 followers 445 following 98 posts

Dad. Scientist. Interested in how Cryptosoridium tricks its host cells!

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Sebastian Shaw @millseba.bsky.social · 13/05/2026
The most surprising part: this resistance-associated ΔAA ndh2 allele is already widespread in C. parvum and C. hominis populations. So Cryptosporidium may carry pre-existing genetic heterogeneity that lets it rapidly adjust under drug pressure.
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Sebastian Shaw @millseba.bsky.social · 13/05/2026
Knocking out ndh2 caused high-level clofazimine resistance, and recombinant CpNDH2 directly reduced clofazimine. In other words: NDH2 helps activate clofazimine, and losing NDH2 helps the parasite escape.
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Sebastian Shaw @millseba.bsky.social · 13/05/2026
Bulk segregant analysis pointed to one sharp locus on chromosome 7. At that locus we found ndh2, encoding type II NAD(P)H dehydrogenase. A small 2-bp deletion near the start of the gene became enriched under drug pressure.
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Sebastian Shaw @millseba.bsky.social · 13/05/2026
We crossed a clofazimine-resistant strain with a susceptible one, selected recombinant progeny in mice, then treated with clofazimine. The treatment suppressed parasite growth, but the infection rebounded. The surviving progeny became more resistant.
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Sebastian Shaw @millseba.bsky.social · 13/05/2026
Different C. parvum strains do not respond equally to clofazimine. That difference gave us a way to genetically map resistance.
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Sebastian Shaw @millseba.bsky.social · 09/05/2026
3rd edition of the cheese bracket, and we have an winner: Cabriolait from Belgium! 🧀 On its way to 1st place, it defeated one Italian, two US, and one Swiss cheese. An impressive run!
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Sebastian Shaw @millseba.bsky.social · 29/03/2026
Did a little experiment with Hannah and her friend from school: they collected some cheek cells from saliva and looked at them under the microscope. Their excitement when the cells came into view was priceless. A nice reminder that even simple experiments can sparkcuriosity. 🔬
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Sebastian Shaw @millseba.bsky.social · 11/03/2026
This week’s family theme 👇🏻👇🏻👇🏻
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Sebastian Shaw @millseba.bsky.social · 19/02/2026
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Sebastian Shaw @millseba.bsky.social · 11/02/2026
Happy International Day of Women and Girls in Science! Let’s continue to support and celebrate them, and fight for equal opportunities for women in STEM! Shout-out to @shubhabevkal.bsky.social and @fra-florini.bsky.social! You’re the best! #WomenInScience #WomenInSTEM
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Sebastian Shaw @millseba.bsky.social · 25/01/2026
Joyful snow day!
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Sebastian Shaw @millseba.bsky.social · 16/07/2025
No ERC Starting Grant this time 😔 7 great reviews — and 1 that… didn’t quite agree. Time to go all in for the SNSF Starting Grant! 💪🏼 Interview in September 🤞🏻🤞🏻🤞🏻
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Sebastian Shaw @millseba.bsky.social · 28/03/2025
Had a wonderful time in New York attending Joe’s defense (he rocked it!) and seeing my PhD buddies Francesca and Shubha and many more 😍
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Sebastian Shaw @millseba.bsky.social · 14/03/2025
I wouldn’t sprint like it’s the Olympics for free food after a seminar.
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Sebastian Shaw @millseba.bsky.social · 12/03/2025
Presented my work at the Joined Parasitology Spring Meeting in Wurzburg today! 😍
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Sebastian Shaw @millseba.bsky.social · 04/03/2025
How many more red flags does it need?
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