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Mike Waring

@mikewaring.bsky.social
345 followers 103 following 17 posts

Professor of Medicinal Chemistry at Newcastle University and Cancer Research Horizons, Director of MoSMed CDT and Editor-in-Chief of RSC Medicinal Chemistry

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Mike Waring @mikewaring.bsky.social · 23/12/2025
New paper out in J Med Chem showing that covalent targeting of C775 has the potential to treat osimertinib resistant lung cancer. Really proud of this work and the team that did it! @nudrugdiscovery.bsky.social @nucancer.bsky.social @crhorizons.bsky.social pubs.acs.org/doi/10.1021/...
pubs.acs.org
Covalent Alkynylpyridopyrimidinones Targeting Cysteine 775 of the Epidermal Growth Factor Receptor Overcome Resistance to Current Therapies
Inhibitors of epidermal growth factor receptor (EGFR) kinase activity are clinically effective treatments for lung cancers driven by activating mutations in EGFR. Resistance to inhibitors develops ove...
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Mike Waring @mikewaring.bsky.social · 13/06/2025
New paper: We've always used TPGS in our micellar #DEL synthesis. This paper shows you can find better ones using @baonguyengroup.bsky.social surfactant map. Great work from Jake Odger et al pubs.rsc.org/en/Content/A...
pubs.rsc.org
Improvements in micelle promoted DNA-encoded library synthesis by surfactant optimisation
DNA-encoded libraries are increasingly important in hit identification at the early stage of the drug discovery process. The approach relies on efficient methods for synthesis of drug-like compounds a...
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Mike Waring @mikewaring.bsky.social · 09/06/2025
Something makes me think that this invite might have been autogenerated...
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CRUK Newcastle Drug Discovery Group @nudrugdiscovery.bsky.social · 13/05/2025
It's official, our med chem Senior Research Associate @hannahstewart92.bsky.social is the world's fastest scientist @guinnessworldrecords.com guinnessworldrecords.com/world-record...
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Mike Waring @mikewaring.bsky.social · 15/04/2025
Starting the @mosmedcdt.bsky.social conference. It will get better from here!
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Mike Waring @mikewaring.bsky.social · 11/04/2025
Group trip to the pub / watch the bins being emptied.
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Mike Waring @mikewaring.bsky.social · 10/04/2025
New paper published today describing some SAR on EGFR inhibitors including an interesting effect of a pair of enantiomers on covalent biinding www.nature.com/articles/s42...
nature.com
Factors affecting irreversible inhibition of EGFR and influence of chirality on covalent binding - Communications Chemistry
Covalent inhibitors are a successful class of drugs, however, the optimization of targeted covalent inhibitors has challenges due to the need to increase non-covalent interactions and modulate reactiv...
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Faces of Science @facesofscience.bsky.social · 07/04/2025
Prof. Mike Waring (@mikewaring.bsky.social), Chair of Medicinal Chemistry, Newcastle University #facesofscience #chemsky #sciencesky
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Faces of Science @facesofscience.bsky.social · 02/04/2025
Nikol Zografou Barredo, PhD Student (Medicinal Chemistry), Newcastle University #facesofscience #chemsky #sciencesky
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Faces of Science @facesofscience.bsky.social · 31/03/2025
Dr Hannah Stewart (@hannahstewart92.bsky.social), Senior Research Associate (Medicinal Chemistry), Newcastle University #facesofscience #chemsky #sciencesky
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Faces of Science @facesofscience.bsky.social · 17/03/2025
Dr Harriet Stanway-Gordon (@harrietsg.bsky.social), Research Fellow (Medicinal Chemistry/Chemical Biology), Newcastle University #facesofscience #chemsky #sciencesky
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Mike Waring @mikewaring.bsky.social · 14/03/2025
Highlighting scientists and the possibility that they may also be humans, give them a follow bsky.app/profile/face...
bsky.app
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Faces of Science @facesofscience.bsky.social · 03/03/2025
COMING SOON! Sneak preview of the selection of people we're showcasing this month 🧪
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Faces of Science @facesofscience.bsky.social · 05/03/2025
Dr Celine Cano, Reader in Medicinal Chemistry, Newcastle University #facesofscience #chemsky #sciencesky
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Faces of Science @facesofscience.bsky.social · 10/03/2025
Dr Grace Roper, PDRA (Medicinal Chemistry), Newcastle University #facesofscience #chemsky #sciencesky
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Faces of Science @facesofscience.bsky.social · 12/03/2025
Dr Suzannah Harnor (@sjharnor.bsky.social), Senior Research Associate (Medicinal Chemistry), Newcastle University #facesofscience #chemsky #sciencesky
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Mike Waring @mikewaring.bsky.social · 10/03/2025
We have a PhD studentship in the @nudrugdiscovery.bsky.social @chemistryncl.bsky.social with me and @hannahstewart92.bsky.social to develop methods of making macrocycles as a new class of antimicrobial agents. Apply at the link and contact us if you have questions. www.findaphd.com/phds/project...
findaphd.com
A Build-couple-transform approach to diverse macrocyclic libraries for antimicrobial drug discovery. at Newcastle University on FindAPhD.com
PhD Project - A Build-couple-transform approach to diverse macrocyclic libraries for antimicrobial drug discovery. at Newcastle University, listed on FindAPhD.com
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Mike Waring @mikewaring.bsky.social · 06/03/2025
Check out RSC Medicinal Chemistry now on Bluesky @rscmedchem.rsc.org
bsky.app
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Mike Waring @mikewaring.bsky.social · 22/02/2025
Yesterday Julian Knight officially retired from @chemistryncl.bsky.social Julian is a brilliant organic chemistry lecturer and will be sorely missed
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Mike Waring @mikewaring.bsky.social · 08/02/2025
Congratulations to Dr Matt Anderson on passing his PhD viva yesterday. @chemistryncl.bsky.social @nudrugdiscovery.bsky.social
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Mike Waring @mikewaring.bsky.social · 31/01/2025
We have a #PhDstudentship starting in Sept with me and @hannahstewart92.bsky.social ideal for candidates with interest in research in #medicinalchemistry and #organicsynthesis Contact us for more details but apply through the university portal, details in the link: www.ncl.ac.uk/postgraduate...
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CRUK Newcastle Drug Discovery Group @nudrugdiscovery.bsky.social · 27/12/2024
Read about our potential breakthrough in oncology - restoring wild type p53 function with ASTX295. This molecule was co-developed with Astex Pharmaceuticals, and is currently showing great phase I trial readout! #cancer #medchem #clinicaltrials www.linkedin.com/posts/cancer...
linkedin.com
Cancer Research Horizons on LinkedIn: #onmyhorizon #cancerresearch
2024 milestones worth celebrating 🧬🌟 Bravo to the incredible researchers at the Drug Discovery Unit at Newcastle University. They've unlocked a potential…
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CRUK Newcastle Drug Discovery Group @nudrugdiscovery.bsky.social · 19/12/2024
Our research is critically dependent on funding we receive from @cancerresearchuk.org and we are also willing to do our bit towards fundraising. In 2024: Funds Raised: £6,440 (+£1,031 gift aid) Online Donations: 283 Events: Great North Run, Race for Life, Shine Walk, Leeds Marathon, bake sale, quiz
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Ute Jungwirth @utejungwirth.bsky.social · 13/12/2024
Exciting collaboration from our @nudrugdiscovery.bsky.social team @newcastleuni.bsky.social, @crhorizons.bsky.social and @diamondlightsource.bsky.social to accelerate hit discovery with structure-based drug design. Big shout out to our structural biology team led by Jane Endicott & Martin Noble!🙌
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Mike Waring @mikewaring.bsky.social · 29/11/2024
Looking forward to speaking at the #scireviewmeeting next week. Some interesting topics...
soci.org
30th SCI Annual Review Meeting – New Directions in Organic Chemistry
The 30th Annual Review Meeting – New Directions in Organic Chemistry, organised by SCI's Young Chemists’ Panel, will address key areas of contemporary synthetic organic chemistry.
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CRUK Newcastle Drug Discovery Group @nudrugdiscovery.bsky.social · 27/11/2024
@utejungwirth.bsky.social and Kleopatra Papa spoke at this week's BACR New Developments in #BreastCancer Research conference, highlighting their work on the effect of chemotherapy on cancer associated fibroblasts and drug resistance 🧫 @nucancer.bsky.social @crhorizons.bsky.social #cancer #cansky
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CRUK Newcastle Drug Discovery Group @nudrugdiscovery.bsky.social · 24/11/2024
Our multidisciplinary team, with strong industry links, specialises in structural fragment-based approaches for class-leading cancer drug discovery complemented by our strengths in synthetic chemistry, innovative target validation technologies & hit matter finding. research.ncl.ac.uk/drugdiscovery/
research.ncl.ac.uk
Cancer Research Horizons Newcastle University | Cancer Research Horizons Newcastle University | Newcastle University
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Mike Waring @mikewaring.bsky.social · 24/11/2024
Newcastle Drug Discovery Group arrives on Bluesky bsky.app/profile/nudr...
bsky.app
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Mike Waring @mikewaring.bsky.social · 23/11/2024
Looking forward to speaking at this on Tuesday. Apparently they are keen to hear about #fraglites and #dels - we will see www.nepic.co.uk/event/nepic-...
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StriveForFive @striveforfive.bsky.social · 22/11/2024
If you or someone you know has stage 4 cancer please take a look at my story and the free resources on www.StriveForFive.org Loads of tips, videos and podcasts. Hope it’s helpful. #stage4 #cancer #RepresentingPatients #Hope
striveforfive.org
STRIVE FOR FIVE
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Shaun Walsh @shaunewalsh.bsky.social · 22/11/2024
Today's must read from my @cancerresearchuk.org colleague Annalisa Belloni👇 The cost of cancer: what does it mean for the UK economy? news.cancerresearchuk.org/2024/11/21/t...
news.cancerresearchuk.org
The cost of cancer: what does it mean for the UK economy? - Cancer Research UK - Cancer News
The OECD's report on the economic impact of cancer makes it clear the UK government needs to focus on tackling the disease.
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Newcastle Chemistry @chemistryncl.bsky.social · 21/11/2024
Thinking of applying to Newcastle for postgraduate study? See details below of an upcoming Postgraduate Virtual Open Day on Wed 27th Nov: www.ncl.ac.uk/study/meet/p...
ncl.ac.uk
Postgraduate Virtual Open Day
Explore your postgraduate study options at our Virtual Open Day on Wednesday 27 November. Sign up now.
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MoSMed CDT @mosmedcdt.bsky.social · 21/11/2024
The Molecular Sciences for Medicine Centre for Doctoral Training is now on Bluesky! We are an EPSRC funded joint venture between Newcastle and Durham Universities aiming to train the next generation of scientists at the interface between chemistry and medicine. 👩‍🔬👨‍🔬🥼🔬🧪 research.ncl.ac.uk/mosmed/
research.ncl.ac.uk
MoSMed CDT | MoSMed CDT | Newcastle University
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