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Mike Hough @mikehough.bsky.social · 16/07/2026

We are recruiting for an exciting PDRA project in data analysis for serial crystallography, details here: nam12.safelinks.protection.outlook.com?url=https%3A... Feel free to get in touch with any questions!

nam12.safelinks.protection.outlook.com

PDRA in Statistical Analysis of Serial Diffraction Data (11878)

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Mike Hough @mikehough.bsky.social · 25/02/2026

An exciting PhD studentship available between the U. of Manchester (Sam Lay) and Diamond Light Source -an opportunity to work with experimental time-resolved structural biology and state-of-the-art computational simulations to gain a deep understandingf enzymes. www.findaphd.com/phds/project...

findaphd.com

Understanding heme enzyme mechanism using dynamic, time resolved crystallography and QM/MM simulations at The University of Manchester on FindAPhD.com

PhD Project - Understanding heme enzyme mechanism using dynamic, time resolved crystallography and QM/MM simulations at The University of Manchester, listed on FindAPhD.com

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Mike Hough @mikehough.bsky.social · 14/01/2026

We have a fixed term beamline scientist post available at VMXi, Diamond. The successful applicant will join the team at a dedicated room temperature MX beamline and help with user experiments in fragment screening and time resolved serial crystallography. vacancies.diamond.ac.uk/vacancy/beam...

vacancies.diamond.ac.uk

Beamline Scientist - VMXi (11779)

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Mike Hough @mikehough.bsky.social · 22/08/2025

Recent paper showing the power of combining advanced structural biology with QM/MM simulations to understand a heme enzyme. Work between Diamond, STFC, Bristol and Essex. We present evidence for the presence of an unusual protein to heme cross-link. pubs.rsc.org/en/content/a...

pubs.rsc.org

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Mike Hough @mikehough.bsky.social · 22/08/2025

New paper describing use of photocaged nitric oxide for time resolved crystallography within fixed targets at XFEL and synchrotron - PhD work of Pete Smyth & Lewis Williams - great collaboration with @jarworrall.bsky.social, beamline I24 and SACLA. Funded by BBSRC journals.iucr.org/m/issues/202...

journals.iucr.org

Time-resolved serial synchrotron and serial femtosecond crystallography of heme proteins using photocaged nitric oxide

We demonstrate the application of a nitric oxide releasing photocage system for time-resolved serial crystallography studies of two heme containing proteins using a fixed target sample delivery system...

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Mike Hough @mikehough.bsky.social · 15/04/2025

Our new paper exploring the effect of XFEL pulse length and pulse intensity on electron density maps of two radiation sensitive proteins. A great collaboration between Diamond, SwissFEL and University of Essex's Worrall group. journals.iucr.org/m/issues/202...

journals.iucr.org

Damage before destruction? X-ray-induced changes in single-pulse serial femtosecond crystallography

Varied pulse-duration and pulse-intensity serial femtosecond crystallography data do not show significant signs of radiation damage under typical experimental conditions.

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Mike Hough @mikehough.bsky.social · 26/11/2024

Just getting started on blue sky - Using this mostly for work purposes, as a brief intro for people I don't already know - I'm a structural biologist at Diamond Light Source specialising in room temperature X-ray structures and serial crystallography at synchrotrons and XFELs

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