A University of Minnesota-led multi-institutional research team has discovered a highly potent small molecule that blocks Ebola virus entry by stabilizing the virus's entry protein and provides strong...

Author summary Since its pandemic spread in 2015–2016, Zika virus infection remains a significant public health threat worldwide. The virus can cause severe brain damage in developing babies and serio...

New research shows the Marburg virus enters human cells far more efficiently than Ebola, highlighting increased outbreak risk and underscoring the need for rapid detection, strict infection control, a...

Marburg isn’t a household name like Ebola, but University of Minnesota researchers created a method for comparison and showed it 300 times more efficient at infecting human cells.

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10240-0 Marburgvirus glycoprotein binds to the endosomal receptor NPC1 in a distinct orientation with higher affinity compared with Ebola virus glycoprotein, accompanied by fusion-relevant rearrangements, enabling more efficient viral entry.

Marburgvirus glycoprotein binds to the endosomal receptor NPC1 in a distinct orientation with higher affinity compared with Ebola virus glycoprotein, accompanied by fusion-relevant rearrangements...