Our Nature Communications paper reports MWAC-3634, a potent, orally active Ebola virus entry inhibitor with a novel mechanism of action. It stabilizes EBOV glycoprotein, neutralizes virus at 0.65 nM, and protects mice after oral treatment.
www.nature.com/articles/s41...
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A small molecule inhibits Ebola virus entry through glycoprotein stabilization - Nature Communications
Researchers identified MWAC-3634, a small molecule that blocks Ebola virus entry by stabilizing its surface glycoprotein, revealing a distinct anti-Ebola strategy. Oral or injected treatment improved ...
