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Micklefield Lab

@micklefield-lab.bsky.social
291 followers 930 following 6 posts

Solvitur ambulando - Biosynthesis; pathway engineering; enzyme discovery-structure-mechanism; biocatalysis & nucleic acids. Imperial College London - Molecular Sciences Research Hub

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Micklefield Lab @micklefield-lab.bsky.social · 04/09/2026
Great video from Bri Barbu, Science Reporter at C&EN, summarising the findings from our most recent Nature paper doi.org/10.1038/s415.... Bri is spot on: our new antifungals, particularly Nys34, have excellent potential for clinical development.
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Micklefield Lab @micklefield-lab.bsky.social · 10/08/2026
Our latest review describes how newly discovered ligase enzymes could enable more sustainable synthesis of peptide therapeutics, highlighting the growing impact of biocatalysis in drug manufacture. doi.org/10.1016/j.cb...
doi.org
Redirecting
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Reposted by Micklefield Lab
Micklefield Lab @micklefield-lab.bsky.social · 29/07/2026
Our latest article in Nature (@nature.com) reports the discovery of pathways to new polyene antifungals that outperform current clinical drugs and act via a different mechanism. Combating #AMR @imperialcollegeldn.bsky.social www.nature.com/articles/s41...
nature.com
Enzymatic glycosylation and amidation reshapes polyene bioactivity - Nature
Pathways to previously undescribed polyenes, including unusual enzymes that introduce more sugars onto polyene scaffolds, are discovered, and their accessibility through clean and efficient fermentati...
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Micklefield Lab @micklefield-lab.bsky.social · 03/08/2026
Excellent commentary and insight from Brianna Barbu at C&EN on our latest paper in Nature www.nature.com/articles/s41... Enzymes open a new path to improve antifungal drugs cen.acs.org/biological-c...
cen.acs.org
Enzymes open a new path to improve antifungal drugs
A biocatalytic platform could offer a scalable strategy for tailoring natural products
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Reposted by Micklefield Lab
Science X / Phys.org @sciencex.bsky.social · 29/07/2026
In mice, the antifungal Nys34 reduced fungal burden without substantial signs of toxicity. It also appears to kill fungal cells differently from amphotericin.
phys.org
New antimicrobials could help tackle deadly drug-resistant infections
Scientists at Imperial College London and the University of Manchester have developed a promising new way to create safer and more effective treatments for life-threatening fungal infections.
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Reposted by Micklefield Lab
Nature @nature.com · 31/07/2026
Nature research paper: Enzymatic glycosylation and amidation reshapes polyene bioactivity go.nature.com/4blUjXP
go.nature.com
Enzymatic glycosylation and amidation reshapes polyene bioactivity - Nature
Pathways to previously undescribed polyenes, including unusual enzymes that introduce more sugars onto polyene scaffolds, are discovered, and their accessibility through clean and efficient fermentation and potential for safe use as antifungal treatments is described.
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Micklefield Lab @micklefield-lab.bsky.social · 29/07/2026
Our latest article in Nature (@nature.com) reports the discovery of pathways to new polyene antifungals that outperform current clinical drugs and act via a different mechanism. Combating #AMR @imperialcollegeldn.bsky.social www.nature.com/articles/s41...
nature.com
Enzymatic glycosylation and amidation reshapes polyene bioactivity - Nature
Pathways to previously undescribed polyenes, including unusual enzymes that introduce more sugars onto polyene scaffolds, are discovered, and their accessibility through clean and efficient fermentati...
0143
Reposted by Micklefield Lab
Imperial Chemistry @imperialchemistry.bsky.social · 29/07/2026
🚨New research from the @micklefield-lab.bsky.social. The team have uncovered a new class of antifungal agents that are more effective and less toxic than existing treatments. Read the full story: www.imperial.ac.uk/news/article...
imperial.ac.uk
New antimicrobials to combat deadly drug-resistant pathogens
Researchers from Imperial College London and The University of Manchester have developed a new family of antifungal compounds that could lead to safe...
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Micklefield Lab @micklefield-lab.bsky.social · 28/07/2026
Hello Bluesky! 👋 We're a research group at Imperial College working at the interface of chemistry, biology & biotechnology. 🔬 #BiosyntheticPathways, #NaturalProducts & #Antibiotics 🧬 #EnzymeStructure, #EnzymeMechanism & #EnzymeEngineering ⚗️ #Biocatalysis & #SustainableSynthesis. News to follow
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