Micklefield Lab @micklefield-lab.bsky.social · 04/09/2026Great video from Bri Barbu, Science Reporter at C&EN, summarising the findings from our most recent Nature paper doi.org/10.1038/s415.... Bri is spot on: our new antifungals, particularly Nys34, have excellent potential for clinical development. 010
Micklefield Lab @micklefield-lab.bsky.social · 10/08/2026Our latest review describes how newly discovered ligase enzymes could enable more sustainable synthesis of peptide therapeutics, highlighting the growing impact of biocatalysis in drug manufacture. doi.org/10.1016/j.cb...doi.orgRedirecting 010
Reposted by Micklefield LabMicklefield Lab @micklefield-lab.bsky.social · 29/07/2026Our latest article in Nature (@nature.com) reports the discovery of pathways to new polyene antifungals that outperform current clinical drugs and act via a different mechanism. Combating #AMR @imperialcollegeldn.bsky.social www.nature.com/articles/s41...nature.comEnzymatic glycosylation and amidation reshapes polyene bioactivity - NaturePathways to previously undescribed polyenes, including unusual enzymes that introduce more sugars onto polyene scaffolds, are discovered, and their accessibility through clean and efficient fermentati... 0143
Micklefield Lab @micklefield-lab.bsky.social · 03/08/2026Excellent commentary and insight from Brianna Barbu at C&EN on our latest paper in Nature www.nature.com/articles/s41... Enzymes open a new path to improve antifungal drugs cen.acs.org/biological-c...cen.acs.orgEnzymes open a new path to improve antifungal drugsA biocatalytic platform could offer a scalable strategy for tailoring natural products 000
Reposted by Micklefield LabScience X / Phys.org @sciencex.bsky.social · 29/07/2026In mice, the antifungal Nys34 reduced fungal burden without substantial signs of toxicity. It also appears to kill fungal cells differently from amphotericin.phys.orgNew antimicrobials could help tackle deadly drug-resistant infectionsScientists at Imperial College London and the University of Manchester have developed a promising new way to create safer and more effective treatments for life-threatening fungal infections. 042
Reposted by Micklefield LabNature @nature.com · 31/07/2026Nature research paper: Enzymatic glycosylation and amidation reshapes polyene bioactivity go.nature.com/4blUjXPgo.nature.comEnzymatic glycosylation and amidation reshapes polyene bioactivity - NaturePathways to previously undescribed polyenes, including unusual enzymes that introduce more sugars onto polyene scaffolds, are discovered, and their accessibility through clean and efficient fermentation and potential for safe use as antifungal treatments is described. 0132
Micklefield Lab @micklefield-lab.bsky.social · 29/07/2026Our latest article in Nature (@nature.com) reports the discovery of pathways to new polyene antifungals that outperform current clinical drugs and act via a different mechanism. Combating #AMR @imperialcollegeldn.bsky.social www.nature.com/articles/s41...nature.comEnzymatic glycosylation and amidation reshapes polyene bioactivity - NaturePathways to previously undescribed polyenes, including unusual enzymes that introduce more sugars onto polyene scaffolds, are discovered, and their accessibility through clean and efficient fermentati... 0143
Reposted by Micklefield LabImperial Chemistry @imperialchemistry.bsky.social · 29/07/2026🚨New research from the @micklefield-lab.bsky.social. The team have uncovered a new class of antifungal agents that are more effective and less toxic than existing treatments. Read the full story: www.imperial.ac.uk/news/article...imperial.ac.ukNew antimicrobials to combat deadly drug-resistant pathogensResearchers from Imperial College London and The University of Manchester have developed a new family of antifungal compounds that could lead to safe... 021
Micklefield Lab @micklefield-lab.bsky.social · 28/07/2026Hello Bluesky! 👋 We're a research group at Imperial College working at the interface of chemistry, biology & biotechnology. 🔬 #BiosyntheticPathways, #NaturalProducts & #Antibiotics 🧬 #EnzymeStructure, #EnzymeMechanism & #EnzymeEngineering ⚗️ #Biocatalysis & #SustainableSynthesis. News to follow 1157