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Miao Yu

@miao-yu.bsky.social
276 followers 106 following 7 posts

Professor at Wuhan University | Biophysicist interested in single-molecule detection🔬🍝

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Miao Yu @miao-yu.bsky.social · 13/12/2025
How liquid-like is the nuclear pore barrier?🍝𖣐 Our new preprint shows that FG-NUPs exhibit nanosecond-scale, liquid-like mobility in living cells. 💧⚡O-GlcNAcylation and an importin-β gradient keep the FG network liquid-like, reconciling nuclear pore complex models.
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Reposted by Miao Yu
IDPSeminars @idpseminars.bsky.social · 30/09/2025
IDPSeminars is back again! Join us this Thursday at 1 pm Central (US) / 7 pm EU time! idpseminars.com
Speakers for this week are:
Gary Daughdrill, U. of South Florida, Role of protein disorder in p53 autoinhibition
Miao Yu, Wuhan University, Revealing the liquid-like permeability barrier of the nuclear pore complex in live cells.
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Reposted by Miao Yu
Lemke Lab @lemkelab.bsky.social · 19/05/2025
Exciting news 🎉 Edward Lemke has been elected as a member of the Academia Europaea! More information can be found here: www.ae-info.org/ae/Acad_Main... @acad-euro.bsky.social
ae-info.org
Academy of Europe: 2025 Elected members
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Miao Yu @miao-yu.bsky.social · 11/02/2025
🚨New Review Alert!🚨How do disordered FG-Nups regulate nuclear transport?🍝🐍 Our latest review explores recent advances in imaging & modeling, linking NPC function to disease. #NuclearPore #FGNups #Biophysics 👉 portlandpress.com/biochemsoctr...
portlandpress.com
Conformational dynamics of the nuclear pore complex central channel
The nuclear pore complex (NPC) is a vital regulator of molecular transport between the nucleus and cytoplasm in eukaryotic cells. At the heart of the NPC’s function are intrinsically disordered phenyl...
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Miao Yu @miao-yu.bsky.social · 08/02/2025
Back in Germany and reunited with my former colleagues from the @lemkelab.bsky.social over a wonderful dinner. It truly feels like coming home!❤️
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Miao Yu @miao-yu.bsky.social · 30/01/2025
Novel analysis of intrinsically disordered proteins🐍📏
embl.org
Novel analysis of intrinsically disordered proteins | EMBL
Mainz University and EMBL Hamburg researchers unveil a new way to characterise disordered proteins using so-called anomalous X-ray scattering.
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Miao Yu @miao-yu.bsky.social · 28/01/2025
Happy Chinese New Year from our lab! 🧧✨ Just as we unravel the mysteries of intrinsically disordered proteins, may the Year of the Snake bring clarity to complexity and spark breakthroughs in our scientific journey. Wishing everyone a year filled with innovation, discovery, and success! 🐍🔬
Here's the translation of our Spring Festival couplet:

First Line: Golden snake dances, revealing a thousand forms.

Second Line: Light and shadow trace its path, painting countless shapes.

Horizontal Scroll: Chaos with Order.
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Reposted by Miao Yu
Philip Ball @philipcball.bsky.social · 21/01/2025
In the cover story of the February issue of @sciam.bsky.social I explain what biomolecular condensates are and why they are transforming cell biology. A short 🧵 (You'll need a subscription to read the article.) www.scientificamerican.com/article/myst...
scientificamerican.com
Mysterious Blobs in Cells Are Changing the Way We Understand Life
Tiny specks called biomolecular condensates are leading to a new understanding of the cell
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Reposted by Miao Yu
Beck Laboratory @becklab.bsky.social · 17/01/2025
In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:
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Reposted by Miao Yu
Mainz University @mainzuniversity.bsky.social · 20/01/2025
Reliable analysis of #IntrinsicallyDisorderedProteins: Researchers of #MainzUniversity and @embl.org Hamburg present new approach to determine the form of disordered proteins by using two different methods simultaneously in a single sample 👉 press.uni-mainz.de/reliable-ana... @imbmainz.bsky.social
Artistic illustration of a researcher examining an intrinsically disordered protein
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Miao Yu @miao-yu.bsky.social · 09/12/2024
Thrilled to share our latest paper in PNAS! We enhanced SAXS with noncanonical amino acid labels to extract both RG and RE of IDPs, addressing key discrepancies in biophysical measurements. Big thanks to Lemke Lab for the amazing ASAXS-inspired T-shirt! www.pnas.org/doi/10.1073/...
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