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MGH Medical Practice Evaluation Center (MPEC)

@mgh-mpec.bsky.social
44 followers 10 following 40 posts

MPEC is dedicated to improving clinical outcomes, increasing value in health policy, and informing public health through research and training mpec.massgeneral.org

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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 02/04/2026
Dr. Ingrid Bassett received the inaugural Public Service Leave from the Harvard Impact Lab and is spending 8 months working part-time with the Massachusetts Department of Public Health. See a blog about her experience working on pediatric immunization here impactlabs.harvard.edu/public-servi...
impactlabs.harvard.edu
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 22/01/2026
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 16/01/2026
Consistent ART use is needed for improved health outcomes and affordable ART is critical. pubmed.ncbi.nlm.nih.gov/41351116/ @anneneilan.bsky.social @andreaciaranello.bsky.social @mgh-mpec.bsky.social @emilyhylemd.bsky.social @clareflanaganmph.bsky.social
pubmed.ncbi.nlm.nih.gov
Projecting lifetime HIV-related healthcare costs for youth with HIV in the United States - PubMed
We projected that US YHIV in care aged 13-24 years would incur nearly $17 billion in lifetime HIV-related healthcare costs. While total costs would increase with improved HIV-related care due to longer life expectancy, monthly costs would be highest during time spent at lower CD4 counts. ART costs w …
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 16/01/2026
A new study by @mgh-mpec.bsky.social investigators in BMC Public Health found that HIV medication price accounts for 74% of projected HIV-related costs for youth with HIV
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 30/12/2025
In this sample of clinical sites in the Boston area, young people were less aware of HIV #PrEP.
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 30/12/2025
MGH investigators analyzed data from sexual health clinic sites in the Boston area and found that among those with #PrEP indications, young females were less likely to be prescribed PrEP compared with male peers and older females @anneneilan.bsky.social
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 17/12/2025
www.massgeneralbrigham.org/en/about/new...
massgeneralbrigham.org
Research Spotlight: How Long-Acting Injectable Treatment Could Transform Care for Postpartum Women With HIV | Mass General Brigham
Researchers at Mass General Brigham used microsimulation modeling to evaluate the clinical impact and cost-effectiveness of offering long-acting injectable treatment to postpartum women living with HI...
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 17/12/2025
This work highlights the need for this life-saving medication to be made available in LMICs at an affordable price. @dgsomucla.bsky.social @hsph.harvard.edu @aadiamd.bsky.social @anneneilan.bsky.social @clareflanaganmph.bsky.social @andreaciaranello.bsky.social @uofalabama.bsky.social
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 17/12/2025
Led by researchers at @mgh-mpec.bsky.social and Zimbabwe-based collaborators, modeling analysis in @jidjournal.bsky.social projects that long-acting injectable ART could prevent infant infections, improve maternal life expectancy and be cost-effective in Zimbabwe. #HIV #maternalandchildhealth
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 09/10/2025
Dr. Ingrid Bassett was one of the recipients of the @impactatharvard.bsky.social's Paid Service Leaves. She will be working with @massdph.bsky.social to design & evaluate childhood vaccination outreach and communication strategies. Read more at: www.hks.harvard.edu/announcement...
hks.harvard.edu
Harvard Impact Labs announces inaugural group of faculty members working to tackle today’s challenges
Ten faculty from six schools will receive funding, training, and public service opportunities to advance solutions-focused research.
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 19/09/2025
Congratulations to Dr. Crystal North on being awarded a CHEST/ALA grant to study community air pollution exposure and COPD.
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 05/09/2025
Details published in @nejm.org @ahri-news.bsky.social @mgh-id.bsky.social www.nejm.org/doi/full/10....
nejm.org
Home-Based Care for Hypertension in Rural South Africa | NEJM
Poorly controlled hypertension is a common problem worldwide, particularly in low-resource settings. We conducted an open-label, randomized, controlled trial of a home-based model of hypertension c...
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 05/09/2025
Just out in NEJM: Drs. Siedner, Gaziano, Magula & colleagues show substantially improved hypertension care in rural South Africa by transferring treatment from clinic to home w/BP machines for self-monitoring, CHW check-ins, and remote care by nurses with an mHealth app.
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 04/08/2025
A new study in @annalsofim.bsky.social found that participants with social risk factors at the time of SARS-CoV-2 infection had greater risk for subsequent long COVID than those without. Read more here: www.acpjournals.org/doi/10.7326/...
acpjournals.org
Social Determinants of Health and Risk for Long COVID in the U.S. RECOVER-Adult Cohort | Annals of Internal Medicine
Background: Social determinants of health (SDoH) contribute to disparities in SARS-CoV-2 infection, but their associations with long COVID are unknown. Objective: To determine associations between SDo...
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 23/07/2025
These findings from the multi-disciplinary team at MGH, EGPAF, and the WHO underscore the substantial clinical and economic benefits of ensuring the availability and implementation of the WHO-recommended AHD package of care globally. #AdvancedHIVDisease @EmilyHyle @KenFreedberg @MGBResearchNews
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 23/07/2025
Including CD4 testing to diagnose people with AHD is critical; strategies that included CD4 testing were preferred and would result in better clinical outcomes and be cost-effective.
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 23/07/2025
In a simulated cohort of 80 000 people living with HIV initiating outpatient ART in Malawi, the total costs over 5 years would increase by $6.98M (compared with ART only) with the WHO-recommended AHD package.
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 23/07/2025
The WHO-recommended AHD package would reduce deaths due to tuberculosis by 30%, cryptococcal meningitis by 25%, and serious bacterial infections by 38%.
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 23/07/2025
In this time of reduced funding to support the critical mission of HIV care globally, this analysis provides strong new scientific evidence to support prioritizing AHD clinical care as very high value.
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 23/07/2025
AHD is diagnosed in ~30%% of people presenting or re-presenting to clinical care in sub-Saharan Africa; it is critical to ensure access to high-quality AHD clinical care and rapid ART initiation that is life-saving.
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 23/07/2025
Hyle et al. found that the WHO-recommended package for advanced HIV disease (AHD) would improve clinical outcomes and quality-adjusted life expectancy and be cost-effective in Malawi and is likely to be cost-effective in most high burden HIV settings. Read here: www.thelancet.com/pdfs/journal...
thelancet.com
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 17/07/2025
Although transmission risk during breastfeeding with an undetectable viral load was not zero, it was very low, supporting evolving US/WHO BF guidelines that recommend shared-decision making about infant feeding. @andreaciaranello.bsky.social Read here: pubmed.ncbi.nlm.nih.gov/40652949/
pubmed.ncbi.nlm.nih.gov
Estimating the effect of maternal viral load on perinatal and postnatal HIV transmission: a systematic review and meta-analysis - PubMed
National Institutes of Health, WHO, and Massachusetts General Hospital.
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 17/07/2025
Dugdale et al. found that maternal HIV viral load was strongly correlated with infant transmission risk. These data support #U=U in pregnancy/birth.
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 18/06/2025
Congratulations to MPEC Investigator Aima Ahonkhai on receiving the HMS Diversity Inclusion and Community Partnership Faculty Fellow Award. This will support her work on Cutting Out Stigma, which uses barbershop-based interventions to combat HIV stigma among Black men in the Southern U.S.
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 29/05/2025
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 27/05/2025
www.thelancet.com/journals/lan... @anneneilan.bsky.social @andreaciaranello.bsky.social @mgh-mpec.bsky.social @alirahmanahmed.bsky.social @linda-gailb.bsky.social @clareflanaganmph.bsky.social @lancetgh.bsky.social
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 27/05/2025
Adolescent girls & young women are disproportionately impacted by HIV in South Africa. MPEC investigators & Desmond Tutu Health Foundation & @yalesph.bsky.social collabs show long-acting cabotegravir for HIV #PrEP for AGYW could reduce infections & transmissions and could be cost-saving at $65/year.
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 10/04/2025
STI testing in hair salons in South Africa reaches women with risk factors for STIs and HIV, appears acceptable and feasible, and reveals a high STI prevalence @mgh-id.bsky.social journals.lww.com/jaids/abstra...
journals.lww.com
Sexually transmitted infection testing integrated with HIV... : JAIDS Journal of Acquired Immune Deficiency Syndromes
Methods: Women attending hair salons are offered oral HIV pre-exposure prophylaxis (PrEP), hormonal contraception, and testing for gonorrhea, chlamydia, trichomoniasis, and syphilis within an ongoin...
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 21/03/2025
@mgh-id.bsky.social @caitlindugdale.bsky.social @andreaciaranello.bsky.social journals.plos.org/plosone/arti...
journals.plos.org
Cost-effectiveness of broadly neutralizing antibodies for HIV prophylaxis for infants born in settings with high HIV burdens
Background Approximately 130 000 infants acquire HIV annually despite global maternal antiretroviral therapy scale-up. We evaluated the potential clinical impact and cost-effectiveness of offering lo...
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 21/03/2025
In a new modeling study, MPEC researchers found that anti-HIV broadly neutralizing antibodies (bNAbs) could prevent up to 42% of new pediatric HIV infections and be cost-effective for all infants born in high (>15%) HIV prevalence settings akin to a vaccine
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 12/03/2025
Dr. Suzanne McCluskey and colleagues are speaking on a panel today at #CROI2025. Join at 4pm PST to hear about their work on integrase failure and resistance! @mgh-id.bsky.social
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 12/03/2025
On the final day of #CROI2025 , see more MPEC research at the 2:30pm PST poster session @emilyhylemd.bsky.social @ankurfactorial.bsky.social @mgh-id.bsky.social
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 12/03/2025
Dr. Mark Siedner presenting on coronary atherosclerosis among PWH in Uganda today at #CROI2025 ! Join the Cardiometabolic Complications & Aging session to listen!
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 10/03/2025
Come hear MPEC investigators share their research at #CROI2025 ! We have several posters during today’s session at 2:30pm PST. @caitlindugdale.bsky.social @anneneilan.bsky.social @andreaciaranello.bsky.social @iddocjen.bsky.social @mgh-id.bsky.social
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 03/03/2025
The bottom line: In South Africa alone over 10 years: 601,000 HIV-related deaths, 565,000 new HIV infections, and $1.7 billion in increased healthcare expenditure. #PEPFAR @mgh-id.bsky.social
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 03/03/2025
MPEC faculty @anneneilan.bsky.social and long-time collaborator Dr. Linda-Gail Bekker contextualize recent research on the impact of abrupt #PEPFAR cuts in @statnews.com www.statnews.com/2025/03/01/p...
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 24/02/2025
Dr. Ingrid Bassett and teams at @ahri-news.bsky.social and @mgh-mpec.bsky.social assessed uptake of PrEP and contraception among women receiving an innovative package of care in hair salons in Durban, South Africa. doi.org/10.1186/s128... #HarvardCFAR
doi.org
A pilot cluster randomized controlled trial assessing uptake of PrEP and contraception in hair salons in South Africa - BMC Public Health
Background Women in South Africa have a high burden of HIV infections, STIs, and unintended pregnancies. Women congregate regularly in hair salons, which may be useful venues for HIV and sexual and re...
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 12/02/2025
MPEC researchers & collaborators project the impact of abrupt #PEPFAR cuts in South Africa, estimating years of life lost and detrimental epidemiological impacts. @anneneilan.bsky.social @andreaciaranello.bsky.social @mgh-id.bsky.social www.acpjournals.org/doi/10.7326/...
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 13/01/2025
Dr. Crystal North was awarded the 2025 Young Physician-Scientist Award by the American Society for Clinical Investigation for making notable achievements early in her research career! Congratulations Dr. North! @the-asci.bsky.social
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MGH Medical Practice Evaluation Center (MPEC) @mgh-mpec.bsky.social · 09/01/2025
Congratulations to Dr. Lisa Bebell on being promoted to Associate Professor of Medicine at Harvard Medical School!
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Reposted by MGH Medical Practice Evaluation Center (MPEC)
MGB Division of Infectious Diseases @mgb-id.bsky.social · 02/01/2025
“Cutting out Stigma”, led by Aima Ahonkhai, MD MPH, is a barbershop-based #HIV intervention focusing on decreasing HIV stigma among Black men in TN. The program was one of three national winners of the HHS HIV-related Stigma and Disparities Challenge! www.hiv.gov/blog/cutting...
hiv.gov
“Cutting Out Stigma” Intervention – Barbershops Link Black Men in Tennessee to HIV Care
Led by Aima Ahonkhai, MD, MPH, the Tennessee Department of Health, one of three Phase 3 winners of the Innovative Community Engagement Strategies to Reduce HIV-...
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Reposted by MGH Medical Practice Evaluation Center (MPEC)
MGB Division of Infectious Diseases @mgb-id.bsky.social · 07/01/2025
academic.oup.com/cid/advance-...
academic.oup.com
Virologic failure and emergent integrase strand transfer inhibitor drug resistance with long acting cabotegravir for HIV treatment: A meta-analysis
Although 48-week virological failure rates were low, emergent integrase resistance among those failing injectable cabotegravir was common (41-71%), and cro
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