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MedChemExpress @medchemexpress.bsky.social · 16/10/2026

Radiotherapy activates p53-TET2 in myeloid cells, reducing caRNA m⁵C and suppressing IRF3–type I IFN signaling to drive immunosuppressive differentiation. TET2 inhibition preserves caRNA m⁵C–MBD6 signaling, restores IFN activation, and promotes antigen-presenting MDACs. ow.ly/XtQ250ZYiTl

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MedChemExpress @medchemexpress.bsky.social · 16/10/2026

🚀From Bench to Paper | #Autoimmune #Alopecia 🧠Treg depletion + sympathetic noradrenaline–ADRB2 signaling activates the ERV–AIM2 pathway, making hair follicle stem cells vulnerable to CD8⁺ T-cell attack. 💡A new neuro-epithelial-immune link to autoimmune #hairloss. #Immunology #Neuroscience

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MedChemExpress @medchemexpress.bsky.social · 15/10/2026

💊 FDA Approvals | #Immunology & #Inflammation 🆕 Explore notable new drug approvals, including brepocitinib, atacicept, difamilast, and more. Discover new indications and pediatric expansions for established therapies. 🧬From PI3Kδ to JAK1/TYK2, explore key targets and emerging treatment advances.

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MedChemExpress @medchemexpress.bsky.social · 15/10/2026

📊 #Ferroptosis Reaches the Clinic: A Phase I trial evaluated CNSI-Fe in 19 patients with refractory solid tumors. • 84.2% DCR in injected lesions • 10.5% ORR in injected lesions • 5.3% overall ORR 🧪 Explore MCE’s products and 1,276-compound Ferroptosis Compound Library: ow.ly/LFZT50ZXVtf

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MedChemExpress @medchemexpress.bsky.social · 15/10/2026

The FDA has expanded the indication for #Anktiva (nogapendekin alfa inbakicept-pmln) + BCG to include adults with BCG-unresponsive non-muscle-invasive bladder cancer with high-grade papillary-only tumors. 🧪Explore Nogapendekin alfa for research use from MedChemExpress: ow.ly/r62r50ZXRES

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MedChemExpress @medchemexpress.bsky.social · 14/10/2026

The FDA has approved #WELTRUZA (#olanzapine), developed by Teva, as an extended-release injectable suspension for adults with schizophrenia. Explore olanzapine for research use from MedChemExpress: www.medchemexpress.com/Olanzapine.h…

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MedChemExpress @medchemexpress.bsky.social · 14/10/2026

🏆Nobel Prize 2026 | #Optogenetics How can light help us understand the brain? 💡🧠 Optogenetics enables precise control of neurons, helping uncover causal links between neural circuits, behavior, cognition, and disease. www.medchemexpress.com/literature/o...

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MedChemExpress @medchemexpress.bsky.social · 13/10/2026

The FDA has approved AbbVie's JUVMO (#tavapadon) for adults with #ParkinsonsDisease, introducing the first and only selective D1/D5 #dopamine receptor agonist approved for the disease. ow.ly/WqGT50ZW8Yj 🧪Explore Tavapadon for research use from MedChemExpress: ow.ly/kC6C50ZW8Yn

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MedChemExpress @medchemexpress.bsky.social · 12/10/2026

📰A new study in Cell identifies #GIMAP6 as a key protective factor against atherosclerotic cardiovascular disease (#ASCVD), revealing a mechanism beyond conventional lipid-related risk. www.cell.com/cell/fulltext/S0092-86…

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MedChemExpress @medchemexpress.bsky.social · 12/10/2026

A new review explores the mechanisms underlying post-COVID-19 tissue remodeling and long-term complications, highlighting how the effects of SARS-CoV-2 may extend beyond the respiratory system. ow.ly/BoRV50ZWIkb SARS-CoV-2-related research tools from MedChemExpress: ow.ly/Y4os50ZWIkc

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MedChemExpress @medchemexpress.bsky.social · 12/10/2026

The FDA has approved #Hovilpri (#pritelivir) for adults with weakened immune systems who have mucocutaneous lesions caused by HSV infection that have not responded to other treatments. 🧪Pritelivir for research use from MedChemExpress: www.medchemexpress.com/BAY-57-1293.…

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MedChemExpress @medchemexpress.bsky.social · 09/10/2026

💊FDA Approvals | Notable Recent Oncology Drugs 🔹#Atezolizumab + chemo— Stage III dMMR colon cancer 🔹#Tucatinib combo— HER2+ breast cancer 🔹#Pirtobrutinib— BTK inhibitor for CLL/SLL 🔹#Belzutifan + #Lenvatinib— advanced ccRCC 🔎Discover bioactive molecules for your research: ow.ly/2s0R50ZWcts

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MedChemExpress @medchemexpress.bsky.social · 09/10/2026

🦟West Nile virus (#WNV) is a mosquito-borne virus. 16 European countries had reported 1,765 locally acquired human cases, according to ECDC. Most infections cause no symptoms, but severe neurological complications can occur. Prevent bites with repellent, long sleeves, and by removing standing water.

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MedChemExpress @medchemexpress.bsky.social · 09/10/2026

The FDA has approved Pfizer’s #TUKYSA (#tucatinib) + #trastuzumab + #pertuzumab for adults with unresectable locally advanced or metastatic HER2-positive breast cancer following induction treatment. 🧪Tucatinib for research use from MedChemExpress: www.medchemexpress.com/Irbinitinib.…

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MedChemExpress @medchemexpress.bsky.social · 08/10/2026

🏆 Nobel Prize 2026: From Chirality to Drug Discovery Left or right? For life, the choice matters. Henri B. Kagan and Kenso Soai showed how small imbalances can amplify chirality through nonlinear effects and asymmetric autocatalysis. 💊 Different enantiomers can have different biological activities.

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MedChemExpress @medchemexpress.bsky.social · 08/10/2026

The FDA has approved #Emcitate (#tiratricol) for the treatment of peripheral thyrotoxicosis in patients with #MCT8 deficiency. 📊Emcitate reduced elevated thyroid hormone levels, improved cardiovascular and metabolic measures Explore Tiratricol for research use from MCE: ow.ly/aQEr50ZVIJZ

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MedChemExpress @medchemexpress.bsky.social · 05/10/2026

🏆 #NobelPrize 2026 | #Optogenetics Karl Deisseroth, Peter Hegemann & Georg Nagel have won the Nobel Prize in Physiology or Medicine. 🧠 💡 Their work enables researchers to switch individual nerve cells on or off with light—transforming #neuroscience and how we understand the brain. #NobelMedicine

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MedChemExpress @medchemexpress.bsky.social · 02/10/2026

🏆#NobelPrize 2026 Countdown | 06 Integrins & cell adhesion How do immune cells know where to go? Timothy A. Springer helped reveal how integrins control immune-cell adhesion and migration, paving the way for therapies like #vedolizumab. 🔬Countdown complete. Nobel Prize announcement: Oct. 5.

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MedChemExpress @medchemexpress.bsky.social · 02/10/2026

🏆#NobelPrize 2026 Countdown | 05 cGAS–STING & innate immunity How does the immune system detect dangerous DNA? Zhijian “James” Chen & Glen Barber helped reveal how cGAS senses cytoplasmic DNA and activates STING, triggering innate immunity. From DNA sensing to cancer immunotherapy.

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MedChemExpress @medchemexpress.bsky.social · 02/10/2026

🏆 #NobelPrize 2026 Countdown | 04 CAR-T & cancer therapy Can a patient’s own immune cells become a living cancer treatment? Zelig Eshhar, Carl June & Michel Sadelain helped turn CAR-T from concept into clinical therapy—engineering T cells to recognize and attack cancer cells.

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MedChemExpress @medchemexpress.bsky.social · 01/10/2026

🏆#NobelPrize2026 Countdown | 03🩸Bispecific antibodies&hemophilia In 2026, Hiroshi Hattori, Tomoyuki Igawa&Takehisa Kitazawa received the Lasker Clinical Medical Research Award for developing emicizumab. By binding factor IXa&X, emicizumab mimics factor VIII and helps prevent bleeding in hemophiliaA.

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MedChemExpress @medchemexpress.bsky.social · 01/10/2026

🏆#NobelPrize 2026 Countdown | 02 😴Orexin & sleep In 2026, Yanagisawa & Emmanuel Mignot received the Lasker Basic Medical Research Award for discovering orexin and its link to narcolepsy. From receptor biology to disease research, their work revealed how orexin helps regulate sleep and wakefulness.

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MedChemExpress @medchemexpress.bsky.social · 01/10/2026

🏆#NobelPrize 2026 Countdown | 01 GLP-1 has reshaped metabolic medicine, from diabetes and obesity to cardiovascular health. In 2026, Daniel J. Drucker, Jens Juul Holst&Svetlana Mojsov were named Citation Laureates for their work on GLP-1. From discovery→drug development→clinical impact 👀What’s next?

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MedChemExpress @medchemexpress.bsky.social · 30/09/2026

🧬Can one kinase be targeted at two sites? A study introduces bitopic inhibition using BCR::ABL1 as a model. PonatiLink-2 links ponatinib and asciminib to target the ATP and allosteric sites, improving activity against resistant mutants and kinase selectivity. The strategy was also extended to EGFR.

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MedChemExpress @medchemexpress.bsky.social · 30/09/2026

September: #MuscularDystrophy Awareness Month 🔹DMD | PMO exon skipping; PPMOs & AOCs aim to improve muscle delivery 🔹DM1 | ASOs & AOCs target DMPK RNA 🔹OPMD | Gene therapy approaches are under exploration 🔹LGMD | Gene therapy & oligonucleotide approaches are being investigated for selected subtypes

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MedChemExpress @medchemexpress.bsky.social · 29/09/2026

🩺World Heart Day | Sept. 29: “Don’t Miss a Beat” Cardiovascular disease (CVD) can develop silently. Everyone needs to raise awareness. Ongoing research is uncovering new therapeutic opportunities across lipid metabolism, thrombosis, and heart failure. ow.ly/aX3Y50ZSvfK

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MedChemExpress @medchemexpress.bsky.social · 28/09/2026

Cell death is not a single process. Beyond well-known apoptosis, researchers have uncovered diverse regulated cell-death pathways, including: 🔹Apoptosis 🔹Necroptosis 🔹Pyroptosis 🔹Ferroptosis 🔹Autophagy-dependent cell death and other emerging mechanisms 📰Read more: ow.ly/XrWZ50ZQpky

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MedChemExpress @medchemexpress.bsky.social · 28/09/2026

🧬How is the drug target landscape evolving? A review found 686 biomolecular targets behind 1,702 approved drugs as of June 2025. 🔹 Peptide targets ↑ 7.2-fold 🔹 136 kinase inhibitors target 67 kinases 🔹 New modalities are expanding the druggable space.

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MedChemExpress @medchemexpress.bsky.social · 25/09/2026

🧬What if we could degrade ALK instead of just inhibiting it? Nature highlights TRI-611, a brain-penetrant molecular glue degrader targeting ALK fusion proteins, including TKI-resistant variants. Could targeted protein degradation offer a new strategy for ALK+ NSCLC?

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MedChemExpress @medchemexpress.bsky.social · 25/09/2026

#MYH9 Emerges as a Key Executor of #Cuproptosis A new study in Cell identifies MYH9 as a key executioner of cuproptosis, a copper-dependent form of cell death. 🧫Copper binds MYH9 → MYH9 polymerization → Cytoskeleton disruption → Cell death

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MedChemExpress @medchemexpress.bsky.social · 25/09/2026

A new review in Trends in Microbiology examines how, when, and through which routes microbes are shared between mothers and infants. 🔗Read more: www.cell.com/trends/microbiology/fu…

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MedChemExpress @medchemexpress.bsky.social · 24/09/2026

💊 #FDA Drug Approvals — September 2026 #Lirafugratinib, #Isembyld & #Zanvastro bring new approaches targeting FGFR, myostatin & RNA. #Sevabertinib, #Camizestrant, #Imlunestrant, #Aqneursa & #Joenja expand therapeutic options across cancer, rare diseases & genetic disorders.

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MedChemExpress @medchemexpress.bsky.social · 24/09/2026

🩸Where do activated platelets go after a blood clot forms? A new Science study points to the spleen, which can capture and clear highly activated platelets. Could this reveal a new angle on thrombosis? #Platelets #Thrombosis #Science

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MedChemExpress @medchemexpress.bsky.social · 23/09/2026

The FDA has approved #Aqneursa (#levacetylleucine) oral suspension to treat ataxia in adults and pediatric patients with ataxia-telangiectasia (A-T) weighing ≥15 kg. 📊Aqneursa improved neurological function as measured by the functional Scale for the Assessment and Rating of Ataxia (fSARA).

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MedChemExpress @medchemexpress.bsky.social · 23/09/2026

A new study analyzed 12151 longitudinal metagenomes from 887 children in the TEDDY study, revealing three distinct patterns of gut microbiome maturation. The findings highlight how early-life microbiome development and host genetics may interact in #T1D susceptibility. ow.ly/i6Ow50ZPZLc

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MedChemExpress @medchemexpress.bsky.social · 22/09/2026

🧬Personalized ASO Therapy Shows Early Signs in Rare ALS A new N-of-1 study reports an individualized ASO therapy for CHCHD10-related ALS. One patient received nL-CHCHD-001 for 12 months. • No serious adverse events • Blood NfL ↓ ~50% • ALS function and breathing remained stable or slightly improved

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MedChemExpress @medchemexpress.bsky.social · 22/09/2026

The FDA approved #imlunestrant + #abemaciclib for adults with ER+, HER2-, ESR1-mutated advanced or metastatic breast cancer following progression on ≥1 line of endocrine therapy. In the phase 3 EMBER-3 trial: 🔹Median PFS: 11.1 vs 5.5 months 🔹HR for progression/death: 0.53 🔹ORR: 35% vs 15%

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MedChemExpress @medchemexpress.bsky.social · 22/09/2026

Nat Rev Drug Discovery: 🔹686 biomolecules modulated by 1,702 drugs as of June 2025 🔹312 new MoA targets introduced since 2000 (84%⬆️) 🔹7.2× increase in endogenous peptide targets Drug Target Identification Services from MCE: www.medchemexpress.com/us/en/drug-t…

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MedChemExpress @medchemexpress.bsky.social · 21/09/2026

💊New #DMD Development The FDA accepted the BLA for Delpacibart zotadirsen and granted Priority Review. A global #Phase3 SAFARI44™ study has also begun. Del-zota is an investigational #AOC designed to deliver PMO to muscle, enabling exon 44 skipping and near-full-length dystrophin production.

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MedChemExpress @medchemexpress.bsky.social · 21/09/2026

A new Nature study identifies mitochondrial fission factor (MFF) as a key regulator linking organelle dynamics to ferroptotic cell death. 🔗https://ow.ly/n17350ZPvms

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MedChemExpress @medchemexpress.bsky.social · 18/09/2026

🧬Prime Assembly: A New Approach to DNA Integration A recent study introduces prime assembly, a #CRISPR-based approach for targeted DNA integration in human cells. 🔹 Cell-cycle independent 🔹 No DSBs 🔹 No dsDNA donors 🔹 Medium-to-large DNA integration 🧪MCE Research Tools for Advancing Research.

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MedChemExpress @medchemexpress.bsky.social · 18/09/2026

💊#Semaglutide: From GLP-1 to Metabolic Health A long-acting GLP-1 receptor agonist first approved for Type 2 Diabetes (#T2D), semaglutide now extends to weight management, cardiovascular risk reduction, and #MASH (F2–F3 fibrosis). 🔬One pathway, multiple therapeutic possibilities.

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MedChemExpress @medchemexpress.bsky.social · 18/09/2026

HIV targets CD4+ T cells, weakening the immune system. Without effective treatment, HIV can progress to AIDS. Antiretroviral therapy (ART) can suppress HIV and help preserve immune function. Fiji has reported a sharp increase in new HIV infections and declared a national HIV crisis in response.

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MedChemExpress @medchemexpress.bsky.social · 17/09/2026

#Endometriosis affects ~10% of women worldwide. 🔬ENDO-205 is an experimental, non-hormonal peptide designed to target endometriotic lesions: lesion tissue → intracellular pathway → lesion regression/disappearance. 🎯With an IND cleared for Phase 1, ENDO-205 is moving into first-in-human evaluation.

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MedChemExpress @medchemexpress.bsky.social · 17/09/2026

89 #CitationLaureates have gone on to receive #NobelPrizes since 2002. The 2026 #CitationLaureates spotlight breakthroughs in: 💊GLP-1 🧬Gene editing 🔬Optical imaging 🧪Immunology Featuring Daniel Drucker, Jens Juul Holst, Svetlana Mojsov, David R. Liu, James G. Fujimoto & Timothy A. Springer.

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MedChemExpress @medchemexpress.bsky.social · 17/09/2026

🧠A new JCI review highlights how mutations in CACNA1A, ATP1A2, and #SCN1A can alter neuronal excitability and increase susceptibility to cortical spreading depression (CSD), a key mechanism underlying migraine aura. www.jci.org/articles/view/208001

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MedChemExpress @medchemexpress.bsky.social · 16/09/2026

The #FDA has approved #Isembyld (#apitegromab-mstn) for adults and children ≥2 years with spinal muscular atrophy (#SMA) who are receiving an SMN2-targeted treatment. 🔬MedChemExpress offers apitegromab for research use only: www.medchemexpress.com/apitegromab.…

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MedChemExpress @medchemexpress.bsky.social · 16/09/2026

🧪Explore 1,000+ compounds across Oncology, Neuroscience, Immunology&Inflammation, and Metabolic Diseases. From HER2, TRIM21 & RAS(ON) inhibitors to PGK1 activators, CCR7 antagonists, and Wnt/β-catenin agonists—new tools for target discovery and translational research. www.medchemexpress.com

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