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Centre for Mechanochemical Cell Biology

@mechanochemistry.org
61 followers 20 following 43 posts

Interdisciplinary research centre at the University of Warwick (UK) with the mission to understand active self-organisation of living systems with a focus on molecular machines, cellular interfaces and tissue mechanobiology

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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 09/06/2026
10 years Bowman lab @bowchro.bsky.social anniversary today, so we are treated to a complete history with all side bets talk. Congratulations 🎉
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 09/05/2026
Last but not least, Kristen Verhey's @kjverhey1.bsky.social closing keynote. She starts off with her top 5 of Rob's papers over the years
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 09/05/2026
Erik Schäffer @schaefferlab.bsky.social uses silicon nanospheres to measure the forces of ultra-weak plant kinesins with sub femtoNewton resolution.
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 09/05/2026
Mark Dodding @markdodding.bsky.social talks about cargo-dependent activation of kinesin-1 through the light chain. Phosphorylation by NEK10 kinase suppresses membrane association of KLC2 specifically and controls lysosome transport by cooperation with cargo adapters.
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 09/05/2026
Our own Masanori Mishima is up next discussing weak electrostatic interactions of motors and tracks that can be regulated by post translational modifications with examples from phosphorylation of KIF23/MKLP1 and arginylation and myosin II.
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 09/05/2026
Varun Ramaswamy is describing how he tackled the difficult problem of determining the structure of full length of HSET
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 09/05/2026
Starting off today is Marija Zanic @zaniclab.bsky.social who introduces us to SSNA1, a sensor for microtubule damage and microtubule stabiliser, that increases their rigidity and protects against breakage
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 09/05/2026
Good morning! Day 2 of our Motors and Filaments meeting is under way.
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 08/05/2026
And the quiz winners are: The Robs
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 08/05/2026
Dinner impressions. Now everyone really knackered after a quiz that felt more like an exam on physical biology of the cytoskeleton. Getting very competitive during the marking process...
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 08/05/2026
The "Vanderbilt girls" on the way to the dinner in the Tocil Wood bluebells.
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 08/05/2026
Evening keynote from Rob Cross summarising 35 years of research to understand how kinesin walks along microtubules featuring the neck linker as position sensor, the load-dependence of dwell time and directionality of steps and the type of microtubule track.
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 08/05/2026
Yean-Ming (Cross lab) talks about the dynamics of different tubulin isotypes and interrogates the lateral interaction regions, generating a chimera that assembled so readily that they also assemble in GDP.
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 08/05/2026
Glenn Carrington (Peckham lab) shows the structure of myosin-5 in a two head bound state on actin and highlights strain-associated changes in the motor domain that explains different ADP release rates from leading and trailing heads.
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 08/05/2026
Some happy faces behind the scenes - this is a reunion of @joehowardd.bsky.social with his former diploma student Frauke Hussmann
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 08/05/2026
Beth Lawrence (Manchester) talks about her postdoc project in the @zaniclab.bsky.social where she showed that human CLASP2 promotes rescues and suppresses catastrophies without affecting microtubule assembly and disassembly speeds. CLASP can convert the pre-catastrophe intermediate state to growth
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 08/05/2026
Jingyi Luo (Ti lab) identifies a single amino acid change in beta3-tubulin that can sensitise cancer cells to paclitaxel by allosteric changes to the taxane binding pocket and by directly stabilising the microtubule lattice by increasing structured water molecules and delayed GTP hydrolysis.
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 08/05/2026
Change of machine: Andrew McMahon describes the elangosome that builds the bacterial cell wall. He is using Minflux to track individual rodA synthase molecules.
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 08/05/2026
Now some theory of beating cilia from Benjamin Friedrich @friedrich-group.bsky.social describing a stochastic dynamic sliding control model.
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 08/05/2026
Alice Brinkworth continues the flagellum theme with cryo electron tomography of microgamete cells from Plasmodium revealing non-canonical microtubule arrangements
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 08/05/2026
Girish Mali @dyneinassembly.bsky.social looks at the recycling of motile cilia after they partially disassembled their cilia under stress.
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 08/05/2026
Last both not least in this session: Xuan describes how to design highly stable red fluorescent proteins beyond the codon expansion strategy the team used before
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 08/05/2026
Time-resolved cryo electron microscopy 🙃 from Carolyn Moores
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 08/05/2026
Carolyn Moores focussed on doublecortin today, a microtubule nucleator stabilising 13 protofilament microtubules specifically. She also acknowledges inspiring and supportive mentors Rob and Ron.
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 08/05/2026
Apolena Zounarova (Straube & Diez labs) talks about dynein-mediated sliding
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 08/05/2026
Marcus Braun discusses how tau changes the microtubule environment for motors and other MAPs
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 08/05/2026
Discussing A, B, C and D lattice microtubules...
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 08/05/2026
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 08/05/2026
On a computer you should be able to switch between both videos. Unfortunately that does not work on phones.
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 08/05/2026
From the livestream screen, click the active stream and then join the session.
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 08/05/2026
You can still join remotely. We will send you the livestream link after you register on our website. For the discussions, reply to our posts with any questions you might have and we will read them out to the speaker on your behalf
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 08/05/2026
First off is Joe Howard who brings us pictures of the past and discusses how cilia beat.
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 08/05/2026
Good morning, about to start our motors and filament meeting. We will keep you updated here throughout today and tomorrow
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 01/05/2026
Glorious weather for CMCB happy hour today hosted by Köster & Straube labs with 🥭 🍦 🍻 and a lot of other tasty treats
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Centre for Mechanochemical Cell Biology @mechanochemistry.org · 24/03/2026
CMCB talk this morning featuring Isaac Wong as part of our ECR seminar series. We learned a lot about centrosome architecture and marvelled at high speed cytoplasmic flows in rectangular diatomes.
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