iiinova — where your digital self keeps evolving

mdmanurung.bsky.social @mdmanurung.bsky.social · 06/08/2025

New post! Here, I highlighted a recent review article on lactate to "fuel" my growing interests in immunometabolism. mikhaeldm.substack.com/p/lactate-fr... A very interesting review to read, which highlight the journey of lactate as metabolic waste to master immune regulator!

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mdmanurung.bsky.social @mdmanurung.bsky.social · 15/07/2025

The mechanism by which CD8T exhaustion (Tex) was regulated remain unclear. In this paper, Dahabieh and colleagues showed how NRF2 involved in promoting CD8 Tex by regulating expression of the prostacyclin receptor PTGIR. Link to my summary: mikhaeldm.substack.com/p/30mpr-ptgi... #immunosky

mikhaeldm.substack.com

30MPR: PTGIR, a novel CD8+T cell immune checkpoint

How metabolic rewiring by prostacyclin receptor signalling limits the immune system's ability to control cancer

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Reposted by @mdmanurung.bsky.social

Yogesh Goyal @goyallab.bsky.social · 06/07/2025

Excited to share our latest by my postdoc Ben KS: we use statistical physics & Bayesian inference to model genome-wide perturbation outcomes. Remarkably, perturbation responses are encoded in gene "chatter" even before the perturbation–a fundamental insight with broad implications shorturl.at/2LHbw

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mdmanurung.bsky.social @mdmanurung.bsky.social · 14/07/2025

I'd like to try something new: sharing the summary of my 30-minute paper reading session--whether I am finished or not! Today I read a paper from Purvesh Khatri's lab on a conserved immune signature that they called as Severe-or-Mild (SoM) score. www.cell.com/immunity/ful...

cell.com

A conserved immune dysregulation signature is associated with infection severity, risk factors prior to infection, and treatment response

The impact of risk factors for severe infections (being old, male, obese, and having comorbidities) on immune dysregulation prior to infection remains understudied. Using 12,026 blood samples, Ganesan...

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mdmanurung.bsky.social @mdmanurung.bsky.social · 13/09/2023

Any single-cell aficionados around here?

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Reposted by @mdmanurung.bsky.social

Thomas Lumley @tslumley.bsky.social · 08/09/2023

The amazing Di Cook and the presumptively amazing Ursula Laa have an online book on high-dimensional data visualisation

dicook.github.io

Interactively exploring high-dimensional data and models in R

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mdmanurung.bsky.social @mdmanurung.bsky.social · 09/09/2023

A year ago, I used to enjoy sharing my learning progress via tweets and blog posts, until I got criticized for sharing something wrong but commonly done in the field (e.g. scRNA-Seq marker gene analysis using t-tests). I cannot control how others should respond, but still, it was disheartening.

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