iiinova — where your digital self keeps evolving

Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 01/12/2025

Kicking off another brilliant @britsocimm.bsky.social Congress with the Bright Sparks PhD session. Always blown away by the quality of the immunology research in this session!

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 01/12/2025

So delighted to have had our first visitor to the lab, Javier Perez Garcia from CNIO, teaching me and Katrine new techniques!

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 26/11/2025

My mum’s response when I described the academic publishing system 😂 I mean, she’s not wrong!

A text about the academic publishing system

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 10/09/2025

Such a nice change of pace to be spending time here visiting Guadalupe Sabio’s lab! Also, such a fun place to do some experiments on my birthday before heading into the city for dinner with friends!

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 16/08/2025

Waiting for the flight to @iuis-online.bsky.social Congress in Vienna, with @juanquintana.bsky.social for a week full of immunology and strudel! Glad that my talk is at the start of the week so I can then kick back and enjoy all the cool science!

A flight information board displaying details for a flight to Vienna

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 18/07/2025

Finally, a beautiful #FluorescenceFriday image to share! Hot off the microscope too! Love how the adipose tissue looks on the confocal 😍 🧪🔬

A confocal microscopy images of adipose tissue

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 05/05/2025

Excited to be here in Crete for the @aegeanconf.bsky.social Immunometabolism meeting! What a gorgeous setting for talking about immunology for a week 😍

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 17/04/2025

Fantastic talk from @carlanowosad.bsky.social on B cells and clonal selection - so much cool data! 🤩

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 19/02/2025

Haha, that’s so cute. My mum in law keeps sending me photos of Alma, our dog, which helps a lot. She’s so beautiful ❤️

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 13/01/2025

So excited to head back to @bidmcreseach.bsky.social next month to learn more tools for research from the Kajimura lab! Fingers crossed for some snowy days too!

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 31/12/2024

Visiting Valencia in Spain, and the Palau de Les Arts is stunning! It’s like a massive beautiful spaceship! 🚀📸

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 30/11/2024

Has anyone been to the Aegean conferences and was it worth it? (Apart from being on a stunning Greek Island that is) 🧪🇬🇷 seems like a pretty incredible setting for a conference…

Image of Sissi on the Greek island of Crete, showing the turquoise sea, the beach and town, and the mountains off in the distance

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 19/11/2024

Yesterday was such a special day, being surrounded by LGBTQ+ immunologist from around the world, as well as allies. Over the years, many people have asked why we need these events, so here’s a couple of reasons 1/🧵 #LGBTQSTEM #Immunosky 🧪🏳️‍🌈🏳️‍⚧️

A lecture theatre full of people, at The STEM Village Immunology Symposium in Manchester

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 18/11/2024

After 5 years, our first in-person event is happening! So grateful to @juanquintana.bsky.social and @alex-cocker.bsky.social for making this happen. And to @drtesutherland.bsky.social and @franzeprogatzky.bsky.social for all of their help!

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 13/11/2024

Here’s the lineup for @thestemvillage.bsky.social Immunology Symposium #Immunosky #PrideInSTEM 🏳️‍🌈🏳️‍⚧️

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 09/11/2024

If I was a well taken care of Hollywood scientist maybe 😂 ChatGPT: based on what you know about me, draw a picture of what you think my current life looks like.

A generative AI illustration depicting what it thinks I look like based on conversations we’ve had

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 09/11/2024

Well, this would have made a pretty #fluorescencefriday image, but it actually didn’t work 😂 just lots of non-specific binding. But hey, we still got pretty, colourful pictures!

Immunofluorescent staining of different brain regions

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 19/10/2024

Lovely autumnal afternoon in Hebden Bridge 🍂 so relaxing and exactly what we needed this week #autumnsky

A river in Hebden Bridge, flanked by trees that are turning colour

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 16/10/2024

I'm pleased to share that I will be speaking at The Festival of Genomics & Biodata, taking place on the 29th-30th of January 2025 at ExCeL London. Registration is free for over 90% of attendees - register now to join in January hubs.la/Q02TptWZ0 #FOG2025 #Immunosky 🧪

The banner shows my photo and announces that I'm speaking at the Festival of Genomics & Biodata at ExCeL in London, which is taking place from 29th to 30th January 2025

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 13/09/2024

This past week has been so hard, saying goodbye to our sweet boy, Igor, but we also realised that we have a lot of love to give to another doggy. So on Sunday we’ll be welcoming Alma to our home ❤️❤️❤️

A brown and white lurcher wearing a harness

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 12/09/2024

Incredible work from Theodore Alexandrov & his team, developing 13C-SpaceM, a new method to perform metabolic tracing at the single cell level. This is so cool! www.nature.com/articles/s42...

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 07/09/2024

After 10 years together (15 for Juan, who got Igor as a 4 month old puppy) it feels like there’s a massive hole in our home. Wish I could wave a wand and bring him back to us

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 05/09/2024

Our angel crossed the rainbow bridge at lunchtime. Knowing it was the right thing to do doesn’t make it any easier. It was peaceful though, and he’s not in pain anymore 💔🐶

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 05/09/2024

Think it might be time for us to say goodbye to Igor. He’s been the sweetest, most loving companion we could have asked for, but he’s struggling so much now 😔 I’m going to miss him so much

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 01/09/2024

And in case you’re interested (as I’ve now been blocked), this is the account spreading propaganda that Maduro is a legitimate leader in Venezuela

A screenshot showing that I’m blocked by Violet News

A screenshot of a post claiming that Maduro is supported in Venezuela

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 01/09/2024

Super interesting exhibition at Factory International, exploring how corporations manipulate consumers to buy their brand of fast food, including using their brand mascots

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 28/08/2024

This from The Sutton Trust. Having experienced this myself, I sadly can’t say I’m surprised. It’s why my accent has changed lots over the years. Still so many people who think that: A) a different accent makes you uneducated/backwards B) it’s acceptable to voice these opinions #AcademicSky

A screenshot of a post from The Sutton Trust linking to their survey showing that 30% of university students had been mocked because of their accent

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 27/08/2024

So nice to be wandering along at work today & to suddenly spot the poster for @thestemvillage.bsky.social Immunology Symposium on the screens. Really lovely to work in such a supportive environment like @lydiabeckeriii.bsky.social where they actively promote inclusion 🥰 #QueerInSTEM

A photo showing a TV screen with a poster for The STEM Village Immunology Symposium

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 23/08/2024

When it's Manchester Pride this weekend and your experiment decides it's going to take longer than normal #QueerInSTEM #AcademicSky

Butterfly meme with the man representing Manchester Pride, the butterfly representing my experiments taking too long so I need to work the weekend, resulting in me asking, "Is my experiment homophobic?" It's meant to be silly and not taken seriously

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 15/08/2024

I’m married to Juan, who is also an immunologist, and we have a 15 year old dog, Igor, who is beautiful and feeling his age We also run a group called The STEM Village to promote inclusion for LGBTQ+ scientists and challenge heteronormative stereotypes 🏳️‍🌈🏳️‍⚧️

A photo of my dog, Igor, staring at the camera while he’s lying down in bed

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 15/08/2024

Time for a reintroduction, since people are leaving Twitter/X & making their way here or to Threads! I’m Matthew, I’m an immunologist (don’t know how that happened!) at Manchester Uni, researching how infections cause weight loss, and how the fat in the skin contributes to this #Immunosky 🧪

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 26/07/2024

🚨🚨 Exciting News! The STEM Village Immunology Symposium is now COMPLETELY FREE! Thanks to our generous sponsors, we have raised enough funds to remove our registration fees! Join us in-person or online on 18th Nov 2024 in Manchester. #ImmunoSky #QueerInSTEM Register here: forms.gle/mRMc4eZtSMrk...

This is a poster advertising The STEM Village Immunology Symposium taking place in Manchester on November 18th 2024. It shows the four invites speakers: Liz Jury, Fred Sheedy, David Bending, and Adrian Liston. It also shows a QR code with a link to registration. The abstract deadline for those wanting to present is 20th September 2024

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 13/02/2024

Over the moon that The STEM Village (@matthew.thestemvillage.com) has been shortlisted for a University of Manchester Making A Difference Award for outstanding contributions to EDI! 🥇 thank you to everyone who has been involved in organising and participating over the years! 🏳️‍🌈🏳️‍🌈 #QueerInSTEM 🧪

An image that says the words “thank you”

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 15/01/2024

So lovely to be able to switch off from science and enjoy views like this over the weekend, as we continue to explore our new home, Manchester 😍

A photo of a canal in Manchester (UK) on a sunny day with blue skies. There are skyscrapers in the background, in contrast to the old red brick buildings surrounding the canal

A photo of a canal in Manchester (UK) at night. There are skyscrapers in the background, in contrast to the old red brick buildings surrounding the canal

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 23/12/2023

Can’t put into words how happy I am that we moved to Manchester this year. Both personally and professionally speaking. And can’t wait to see what 2024 holds for me and @juanquintana.bsky.social. Merry Christmas everyone! 🎄🎄🎄

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 24/10/2023

Oh wow, we really picked a great spot for the new flat! Looking forward to getting back into the lab tomorrow to get on with the new position 😍 📸📷

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 22/10/2023

Made it to Manchester! Having so much fun exploring the city before we start work in person next week!!

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 10/10/2023

Suuuper excited that we’ve brought our moving date forward a few days and we’re moving to Manchester next week! Excited for the new job, and for moving to such a cool city! 📸

Mural of Lily Savage in the Gay Village, Manchester, UK

Murals in the Northern Quarter, Manchester, UK

Photograph of the canals in Castlefield, Manchester, UK

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 06/10/2023

In one night we met Cleve Jones AND Lady Camden 😍 it’s the queer night of my dreams!!

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 04/10/2023

Another example in the Guardian of just how deranged and dangerous the government have become. Suella Braverman calling the Human Rights Act the Criminal Rights Act is, frankly, outrageous and unacceptable. We desperately need these people out of power #GeneralElectionN0W

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 03/10/2023

Oh no, we'd better stop our queer immunology seminar series then... For crying out loud, this government are a disgusting mob, just desperate to distract from their gross incompetence/corruption by stoking their culture wars Screw that! Proud to be #LGBTQSTEM 🏳️‍🌈🏳️‍⚧️🏳️‍🌈🏳️‍⚧️

Screenshot of a tweet from the UK Conservative Party, saying that they want to “safeguard” scientific research from woke ideology

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 03/10/2023

Using Suramin to prevent the CNS stage of the disease, we showed that the accumulation of meningeal GL7+ CD95+ GC-like B cells, the deposition of autoreactive antibodies, and the resulting cortical demyelination depend upon parasite accumulation in the CNS. 6/8

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 03/10/2023

We next decided to explore the nature of the host antigens recognised by the infection-induced autoantibodies. We found several antigens commonly detected in mice and chronic HAT patients, including myelin basic protein, coinciding with the demyelination we see in this model. 5/8

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 03/10/2023

We also showed that in addition to plasma cells, there was a fraction of CD19+ B cells that expressed GL7 and CD95 during infection, confirming their germinal centre-like phenotype, potentially explaining the generation and deposition of local autoantibodies. 4/8

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 03/10/2023

Unfortunately, in our hands, meningeal myeloid depletion with liposomes (or other genetic models) during chronic infection resulted in exacerbated pathology and precluded us from addressing whether mononuclear phagocytes drive local T cell activation at this stage 3/8

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 03/10/2023

First, we confirmed the presence of CXCR5+ PD1+ IL-21+ Tfh-like CD4+ T cells in the infected meninges. In collaboration w/ @BendingLab, we found signs of new & persistent CD4+ T cell activation, but CD8+ responses seem more transient. See Nur77Tempo: pubmed.ncbi.nlm.nih.gov/36704407/ 2/8

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · 22/09/2023

I love San Francisco so much! It’s so photogenic 📸 📷

Neon signs of a psychic shop in San Francisco

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