McCabe Lab @mccabelab.org · 08/06/2026Minis, aka spontaneous synaptic neurotransmitter vesicle release, was long dismissed as noise. Our new 📄 using optical electrophysiology shows minis are not spontaneous at all. They're an independent release modality regulated by Unc-5 & critical for synapse preservation 👉 doi.org/10.64898/202... 022
McCabe Lab @mccabelab.org · 04/02/2026New manuscript by Evelyne 👉 pBID2 series of standardized, optimized #Drosophila vectors enables parallel generation of Gal4, LexA & QF2 + UAS, LexOp & QUAS lines. 🆕 is QFG4, a QF–Gal4 hybrid, allowing Gal80-coordinated temporal control of independent UAS & QUAS transgenes doi.org/10.64898/202... 133
McCabe Lab @mccabelab.org · 12/08/2025Weird results from CRISPR/Cas9 Homology Directed Repair (HDR) based genome editing? We show that frequently the HDR template vector becomes incorporated into the genome causing all sorts of problems. For #Drosophila, we develop a vector to detect these unwanted events www.biorxiv.org/cgi/content/... 010
McCabe Lab @mccabelab.org · 30/03/2025Many congratulations to lab member Medha Raman for winning the EPFL final of MT180 - My Thesis in 180 seconds 021