@schvartzman.bsky.social and I wrote a perspective on how dynamic metabolite-protein interactions can shape cell biology, and the open questions this raises about the broad roles of metabolism. It was fun to dig into Zabala-Letona, Carracedo et al.'s story as an example of this! tinyurl.com/4tcnrydm
tinyurl.com
Precision from broad strokes: How the non-specific interactions of metabolites and macromolecules can regulate biology
In a recent article in Nature, Zabala-Letona et al.1 propose that polyamines—small, positively charged metabolites—regulate RNA splicing by electrosta…
