Very excited to share the culmination of this wonderful collaborative effort, which reveals a mechanism by which QKI facilitates exon inclusion at transcripts with ‘weak’ 5’ splice sites during cardiogenesis, providing new insight into RBP-mediated splicing regulation www.biorxiv.org/content/10.1...
biorxiv.org
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites
During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...
