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Matthew Sydes

@mattsydes.bsky.social
484 followers 726 following 17 posts

linktr.ee/mattsydes Head of Data-Driven Clinical Trials at NHS England. Hon Prof of Clinical Trials & Methodology at UCL. Hon Fellow at HDRUK. Always keen to talk clinical trials & evidence-based healthcare. Tied to kettle & news. Local trips by bike.

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Reposted by Matthew Sydes
Katie Gillies @katiegillies.bsky.social · 20/05/2025
Founders Lecture #SCT2025 on DMCs - Thomas Fleming flags the @nihr.bsky.social funded DAMOCLES study that developed a charter for DMCs to support them to do their jobs well. Full paper here www.thelancet.com/journals/lan...
thelancet.com
A proposed charter for clinical trial data monitoring committees: helping them to do their job well
Formal monitoring of data from randomised controlled trials (RCTs) is becoming more common. Wide variation exists in the structure and organisation of data monitoring committees (DMCs), with little gu...
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Reposted by Matthew Sydes
Marion Campbell @marionkcampbell.bsky.social · 20/05/2025
Hard to believe it is now 20 years (!) since we published the DAMOCLES Charter to support data monitoring committees do their job well. It is still routinely used to inform all NIHR DMCs today 😊 @mattsydes.bsky.social
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Matthew Sydes @mattsydes.bsky.social · 20/05/2025
My most recent blog post for NHSE on clinical trials is here: digital.nhs.uk/blog/data-poin… It's my contribution for #ClinicalTrialsDay. It's a personal story. My take-away message for you is: "Every person that ... joins any trial is a hero."
digital.nhs.uk
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Matthew Sydes @mattsydes.bsky.social · 03/04/2025
And some bonus #TrainMisery. No work anniversary would be complete without a reminder of how many times I've been let down on the commute to London. 5/5
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Matthew Sydes @mattsydes.bsky.social · 03/04/2025
I tried to catch a panel session on #AI and real-world data #RWD across London to end the day but the stars didn't quite align to catch it all. ("Good" to see those organiser's had made a classic Trials / Trails typo on their banner stands. Don't see that much now...) 4/5
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Matthew Sydes @mattsydes.bsky.social · 03/04/2025
Then gave on talk on #HealthcareSystemsData and the NHS Research SDE Network #SecureDataEnvironments and Clinical Trials in a great afternoon session at @imperialctu.bsky.social Contemporary Clinical Trials Methodology Meeting. 3/5
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Matthew Sydes @mattsydes.bsky.social · 03/04/2025
I helped chair a good session on Trials and #NHSDigiTrials at today's Health Data User Group #HDUG meeting. (Sign up for the next one via data.healthresearch@nhs.net) @NHSDigital 2/5
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Matthew Sydes @mattsydes.bsky.social · 03/04/2025
It is my 30th anniversary of working in #ClinicalTrials today! I don't think I feel old enough to have hit this milestone, yet started at MRC Cancer Trials Office on 03-Apr-1995. How to celebrate? Talking about better clinical trials, of course! Here's how... 1/5
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Matthew Sydes @mattsydes.bsky.social · 03/04/2025
This morning, I helped chair a good session on trials and #NHSDigiTrials at today's Health Data User Group #HDUG meeting. digital.nhs.uk/data-and-inf...
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Matthew Sydes @mattsydes.bsky.social · 12/03/2025
It helps show direction of research community & set priorities for how we build invitations to participate in research with the richness of healthcare systems data the SDE Network will hold.
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Matthew Sydes @mattsydes.bsky.social · 12/03/2025
And it's not just about this year: express your interest now for ideas you want to run in the future. Signalling your interest, incl. in working with datasets that aren't yet easily available, is good.
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Matthew Sydes @mattsydes.bsky.social · 12/03/2025
Did you see the EOI has opened a new tranche of trials to recruit with NHS DigiTrials? You'll know someone with a trial that should explore this. Apply now: lnkd.in/eiczmNpD #NHSDigiTrials #ClinicalResearch #Healthcare #Innovation
QR code which links to the hyperlink already in the text. 
And clarification that applications for FY25/26 should be submitted by 11-Apr-2025Snapshot of the LinkedIn post at https://www.linkedin.com/posts/nhs-transformation-directorate_nhsdigitrials-clinicalresearch-healthcare-activity-7302360165935140866-ZQHG title "Transforming clinical trial recruitment"
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Reposted by Matthew Sydes
Nick James @prof-nick-james.bsky.social · 04/03/2025
Latest from #STAMPEDE - intensified AR targeting drives increased prevalence of AR mutations at progression compared to monotherapy patient samples jamanetwork.com/journals/jam...
jamanetwork.com
Plasma AR Alterations and Timing of Intensified Hormone Treatment for Prostate Cancer
This randomized clinical trial explores whether hormone intensification at start of androgen deprivation therapy alters selection of androgen receptor (AR) gene alterations within the gene body and/or...
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Matthew Sydes @mattsydes.bsky.social · 17/01/2025
Well done @timpmorris.bsky.social ! Brilliant to see this made available. And let's hope StataCorp feel suitably and constructively provoked.
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Reposted by Matthew Sydes
Tim Morris @timpmorris.bsky.social · 17/01/2025
Stata users: if you want to make ‘kmunicate’-style Kaplan–Meier graphs, I’ve just released a Stata package on GitHub. To get it: . net from raw.githubusercontent.com/tpmorris/kmu... User feedback welcome! 1/
A vanilla KMunicate-style Kaplan–Meier graph from {kmunicate}. Key is the extended risk table showing the status of participants over time.
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Matthew Sydes @mattsydes.bsky.social · 05/11/2024
Sorry to link out to LinkedIn and Twitter. None of the originators seem to have accounts here.
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Matthew Sydes @mattsydes.bsky.social · 05/11/2024
1=Absolutely delighted to one of HDR UK's inaugural Honorary Fellows 2=Looking forward to launch of Sudlow Review on UK Health Data Friday AM. If not in the room, watch the livestream 3=Enhanced Gateway will help unlock power of NHS data for research through the NHS Research SDE Network
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Matthew Sydes @mattsydes.bsky.social · 05/11/2024
3 things that are on my mind: ▶️1 = HDR UK Honorary Fellows www.linkedin.com/posts/hdruk_... or x.com/HDR_UK/statu... ▶️2 = Sudlow Review www.linkedin.com/posts/hdruk_... or x.com/HDR_UK/statu... ▶️3 = Enhanced Health Data Research Gateway www.linkedin.com/posts/nhs-tr... or x.com/NHSDigital/s...
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Matthew Sydes @mattsydes.bsky.social · 10/10/2024
If you are missing (or sad about having missed) #ICTMC2024 from last week or #HDUG from this week, now's a good time to grab a cup of tea & read my first blog since joining NHS England Transformation Directorate's Data for R&D Programme. Here's a handy link: digital.nhs.uk/blog/data-po...
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Matthew Sydes @mattsydes.bsky.social · 26/09/2024
***JOB ALERT*** I'm sure many of my #clinicaltrials colleagues in #industry and #academia will be interested in this advert for the Head of Data Operations for #DigiTrials at NHS England. Link at beta.jobs.nhs.uk/candidate/jo... Tight deadline (Sunday 06oct2024) just after #ICTMC2024.
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Matthew Sydes @mattsydes.bsky.social · 09/04/2024
Absolutely agree. That word stops my ability to take in anything else that person is saying around that time.
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