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The Matile Group @matilegroup.bsky.social · 27/09/2026

Our new paper in Angew. Chem. on the mode of action of cell-penetrating poly(disulfide)s (CPDs) uplifts the understanding of thiol-mediate uptake (TMU) to a new level of confidence and completion. onlinelibrary.wiley.com/doi/10.1002/...

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The Matile Group @matilegroup.bsky.social · 27/09/2026

What a memorable PhD defense, what an achievement: Congratulations to Dr. Julia Moreno, and very best wishes for the future!

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The Matile Group @matilegroup.bsky.social · 07/09/2026

Our new paper on electric-field catalysis of iminium chemistry introduces two extremes: Catalytic Helmholtz layers from charged reactive intermediates and the emergence of the Goldilocks inverted region. Now new in CCSC, the DOA top journal of the CCS: www.chinesechemsoc.org/doi/10.31635...

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The Matile Group @matilegroup.bsky.social · 31/07/2026

2 Peaks, 4 lakes and 1 castle (with wine museum and wine tasting): A memorable group excursion to close a fruitful academic year in style.

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The Matile Group @matilegroup.bsky.social · 27/07/2026

Our new paper in ACS Centr. Sci. is really special for us: We challenge our emerging mechanistic principles for catalysis with external electric fields under organic synthesis conditions with the holy grail in the field, and they pass, with distinction. pubs.acs.org/acscii/artic...

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The Matile Group @matilegroup.bsky.social · 13/06/2026

Wonderful collaboration - congratulations!

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The Matile Group @matilegroup.bsky.social · 05/06/2026

Traceable traceless delivery tags: The tasty title of our new paper in Helv. Chim. Acta refers to the dual function of asparagusic acid, thiol-mediated uptake and Golgi tracking, at best inner membrane leaflet, cis Golgi lumen and trafficking from threre. onlinelibrary.wiley.com/doi/10.1002/...

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The Matile Group @matilegroup.bsky.social · 17/04/2026

Our new paper in ChemistryEurope applies electric-field catalysis under organic synthesis conditions to Jørgenson-Hayashi-type chemistry. With amines separated from acids, EFC mechanisms with prolinol ethers differ from prolines: chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

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The Matile Group @matilegroup.bsky.social · 10/04/2026

This is a very special moment for us, a big old dream come true: Our new paper in JACS Au provides the conceptual mechanistic framework for electric-field catalysis (EFC) at high voltage under practical organic synthesis conditions. Thank you JACS Au (GOA, ACS): pubs.rsc.org/en/content/a...

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The Matile Group @matilegroup.bsky.social · 20/02/2026

In our new paper in Chem. Sci., a final firework culminates with flippers that are not only as big and as beautiful as it gets but also solve a real problem and provide access to the imaging of membrane tension in living cells over longer periods of time. pubs.rsc.org/en/content/a...

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The Matile Group @matilegroup.bsky.social · 20/12/2025

Congratulations to Dr. Nerea González-Sanchis for a successful PhD defense, the final flipper firework with beautiful structures that solve real problems. Very best wishes for the future! A big thank you to the members of the jury, Sascha Hoogendoorn, Sander Wezenberg and Jerome Lacour.

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The Matile Group @matilegroup.bsky.social · 06/12/2025

This was the 2025 edition of the traditional group dinner in the Edelweiss, newly renovated, cheese fondue, meat fondue, chocolate fondue, live jodel, alphorn and kirsch

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The Matile Group @matilegroup.bsky.social · 22/11/2025

The current #1 Bestseller of Helv. Chim. Acta, the Journal of the Swiss Chemical Society, founded 1917, is our paper with the groups of Thomas Poulsen (Aarhus, Denmark) and Oliver Thorn-Seshold (Dresden, Germany): Thank you so much for reading! onlinelibrary.wiley.com/journal/1522...

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The Matile Group @matilegroup.bsky.social · 17/11/2025

In our new review in Helv. Chim. Acta, we summarize the first decade of CPDs – cell-penetrating poly(disulfide)s - comprehensively. It was gratifying to see how useful their thiol-mediated uptake has become in practice, also in living animals. onlinelibrary.wiley.com/doi/10.1002/...

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The Matile Group @matilegroup.bsky.social · 06/11/2025

Our new paper in Angew. Chem. could make thiol-mediated uptake more generally useful for the community, at last: Grafting CPDs to SOIs rather than the original grafting-from provides the fast bioconjugation needed. Thank you, Angew. Chem. (open access): onlinelibrary.wiley.com/doi/10.1002/...

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The Matile Group @matilegroup.bsky.social · 31/10/2025

Congratulations to Dr. Felix Bayard for a successful PhD defense, covering impressive synthetic efforts to reduce the phototoxicity of mechanosensitive flipper probes: Very best wishes for the future! A big thank you to the members of the jury, Anthony Davis, Michel Rickhaus and Jerome Lacour.

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Reposted by The Matile Group

Chemical Science @chemicalscience.rsc.org · 24/10/2025

Issue 40 is here! #ChemSciCovers Our front cover this week features Stefan Matile et al 🤩 'Thiol-mediated uptake of phosphorothioate liposomes, visualized with fluorescent flippers' 🔗 doi.org/10.1039/D5SC... bsky.app/profile/matilegroup.bsky.s…

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Reposted by The Matile Group

Angewandte Chemie @angewandtechemie.bsky.social · 24/10/2025

@matilegroup.bsky.social spotlights work from @mvdelius.bsky.social and co-workers on dynamic thioorthoester chemistry for metal-scavenging networks and sulfur-rich cathodes in Li batteries. Read more: onlinelibrary.wiley.com/doi/10.1002/... #AngewandteChemieNovit

onlinelibrary.wiley.com

Translational Supramolecular Thioorthoester Chemistry

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The Matile Group @matilegroup.bsky.social · 16/10/2025

Look at these shiny flippers, so many: pubs.rsc.org/en/journals/...

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The Matile Group @matilegroup.bsky.social · 30/09/2025

In our new paper in Chem. Sci., we show that the replacement of one oxygen by one sulfur atom in phospholipids affords phosphorothioate liposomes that penetrate cells by thiol-mediated uptake in intact form and with contributions neither from fusion nor from endocytosis.

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The Matile Group @matilegroup.bsky.social · 27/09/2025

Congratulations for an intriguing PhD defence and very best wishes to Dr. Michael Cognet for a great future. A big thank you to the members of the jury, Kurt Gothelf, Nicolas Winssinger and Clement Mazet.

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The Matile Group @matilegroup.bsky.social · 23/09/2025

Our new paper in Angew. Chem. introduces an enabling method to make catalysis with externally applied electric fields compatible with organic synthesis. onlinelibrary.wiley.com/doi/10.1002/...

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The Matile Group @matilegroup.bsky.social · 16/09/2025

For a great start into the new academic year, we climbed up to the largest glacier in the Alps, a UNESCO World Heritage Site.

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The Matile Group @matilegroup.bsky.social · 08/09/2025

This invited commentary in Angew. Chem. highlights the importance of translational supramolecular chemistry, and the power of the big yellow sulfur atom in this context, despite its diabolic reputation. onlinelibrary.wiley.com/doi/10.1002/...

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The Matile Group @matilegroup.bsky.social · 29/08/2025

Our new paper in Helv. Chim. Acta, the Journal of the Swiss Chemical Society, founded 1917, elaborates on unorthodox reversible Michael addition for cellular uptake; with the groups of @tbpoulsen.bsky.social‬ and @oliverthornseshold.bsky.social‬. onlinelibrary.wiley.com/doi/10.1002/...

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The Matile Group @matilegroup.bsky.social · 26/08/2025

552 flippers and a few crabs, what a cover, please enjoy Thank you, JACS Au: pubs.acs.org/doi/10.1021/...

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The Matile Group @matilegroup.bsky.social · 18/08/2025

Thank you so much for reading: Our new paper on photocatalytic microenvironment proteomics of thiol-mediated uptake still hangs on in the top 20 of JACS Au. It aims to give a better understanding of a process that might be more important than we all expected. pubs.acs.org/doi/10.1021/...

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The Matile Group @matilegroup.bsky.social · 06/08/2025

In our new paper in JACS Au, with the Sagara group from the Institute of Science Tokyo, we introduce flippers than respond to stretching rather than compression and applicability to the materials rather than the life sciences (GOA). pubs.acs.org/doi/10.1021/...

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The Matile Group @matilegroup.bsky.social · 02/07/2025

Photocatalytic microenvironment proteomics identifies proteins in thiol-mediated uptake by covalent labeling without disturbing exchange network dynamics. We hope our new paper will help the community to better understand, explore and use this enigmatic process. pubs.acs.org/doi/10.1021/...

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The Matile Group @matilegroup.bsky.social · 02/06/2025

Violating the EDB rules, access to intrinsically disfavored products increases with increasing electric fields applied to electromicrofluidic reactors with carbon nanotubes (besides conversion going from 0 to 100%). Now new in Chem. Sci., pubs.rsc.org/en/content/a..., Diamond Open Access, RSC

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The Matile Group @matilegroup.bsky.social · 28/05/2025

Thank you very much for highlighting our paper

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The Matile Group @matilegroup.bsky.social · 28/01/2025

Congratulations to Filipe Coelho for a great PhD defense, on uptake exchange partners, integrins, PDIs, cell motility, selenenylsulfides, and more. Many thanks for all and very best wishes for a bright future. Special thanks also to jury members, specially C. Hackenberger, who came from far.

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The Matile Group @matilegroup.bsky.social · 25/11/2024

An update on dynamic covalent cascade exchange chemistry, thiol-mediated uptake and the CH-ERC AdG TIMEUP, now new in Chimia, the POA Journal of the Swiss Chemical Society. www.chimia.ch/chimia/artic...

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The Matile Group @matilegroup.bsky.social · 22/11/2024

Congratulations, Angie - Dr. Gutiérrez-López for an excellent PhD defense on “Microfluidic Electric-Field Catalysis on Carbon Nanotubes and the Origin of Anion-π Autocatalysis” A big thank you for all and best wishes for the future! Many thanks also to the jury, M. Prato, C. Mazet, J. Lacour

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The Matile Group @matilegroup.bsky.social · 19/11/2024

Hello #ChemSky, we are a research group in Geneva, Switzerland, interested in translating principles from supramolecular chemistry to address significant challenges at the interface of organic chemistry, chemical biology and materials.

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