Our preprint is out! 🧠🎉
How can we watch a mammalian brain circuit assemble while preserving its native connectivity?
Hindbrain explants let us follow the olivo-cerebellar circuit from before synaptogenesis through functional maturation at single-cell resolution.
www.biorxiv.org/content/10.6...
biorxiv.org
Hindbrain explants enable multimodal and longitudinal analysis of the developing olivo-cerebellar circuit at single-cell resolution
Experimental models that preserve native mammalian CNS circuitry while enabling longitudinal analysis of circuit assembly at single-cell resolution remain scarce, limiting mechanistic studies and ther...
