iiinova — where your digital self keeps evolving

Mass Lab @masslab.bsky.social · 06/12/2025

🧬🍽️ Your macrophages may be carrying your mother’s metabolic history! In our @cp-trendsimmuno.bsky.social article, we discuss how maternal diet programs lifelong immune function. authors.elsevier.com/sd/article/S... #ImmuneMemory #Macrophages #MaternalNutrition #DOHaD #EarlyLifeProgramming

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Mass Lab @masslab.bsky.social · 17/07/2025

🧠 New book chapter out! We review the developmental origin and functional diversity of #microglia - key players at the crossroads of #immunity and #neurodevelopment. 🔹 Ontogeny & specialization 🔹 Transcriptional & metabolic shifts 🔹 Roles in disease & repair 👉 authors.elsevier.com/a/1lKxcErwXf...

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Mass Lab @masslab.bsky.social · 18/06/2025

8/ Live-imaging of hepatocytes exposed to ApoE confirmed: → ApoE and ApoA1 alone was sufficient to cause lipid droplet accumulation

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Mass Lab @masslab.bsky.social · 18/06/2025

7/ Multi-omics profiling (bulk & single-nucleus RNA-seq + ATAC-seq + proteomics) revealed: ✅ Apolipoproteins ApoE and ApoA1 are upregulated in reprogrammed KCs ✅ They act via paracrine signaling to induce steatosis in hepatocytes

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Mass Lab @masslab.bsky.social · 18/06/2025

6/ Using a double fate-mapping model, we confirm that these disease-driving KCs remain yolk sac–derived — not replaced by monocyte-derived macrophages, as seen in diet-induced FLD.

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Mass Lab @masslab.bsky.social · 18/06/2025

3/ Using a mouse model, we show that maternal obesity causes long-term transcriptional, metabolic & epigenetic changes in KCs. These reprogrammed KCs persist into adulthood and promote lipid accumulation in hepatocytes, leading to fatty liver disease (FLD).

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Mass Lab @masslab.bsky.social · 07/05/2025

Just presented our story on #KupfferCells #liver & #microplastics togehter with @mariafviola.bsky.social in the basic science session @ #EASL2025 in #Amsterdam. Great format to promote ECRs and for fantastic discussions with scientists and clinicians!

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Mass Lab @masslab.bsky.social · 23/04/2025

Read our newest publication @jem.org about #microglia and #CD8Tcell interactions in spastic paraplegia! 💡Immune activation happens before #neuronal loss! 💡 Team effort with the labs of Marc Beyer and Ralf Stumm 👇 doi.org/10.1084/jem.... @limes-bonn.bsky.social @immunosens.bsky.social #immunosky

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Mass Lab @masslab.bsky.social · 18/03/2025

7/ ❗ The long-term problem: Even after a 6-month washout period, MNPs were still present in liver macrophages, although metabolism recovered. This raises concerns about cumulative effects over a lifetime.

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Mass Lab @masslab.bsky.social · 18/03/2025

6/ 🧠 Surprisingly, even though some NPs reached the brain, we found no major changes in behaviour or inflammation. The blood-brain barrier seems to limit MP entry, keeping the brain mostly protected - at least under healthy conditions.

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Mass Lab @masslab.bsky.social · 18/03/2025

5/ 🍔 When combined with a high-fat diet, MPs worsened liver fat storage, while NPs led to glucose intolerance. This suggests that chronic MNP exposure can amplify metabolic disorders.

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Mass Lab @masslab.bsky.social · 18/03/2025

4/ 🆚 Size matters! #Microplastics (MPs, 500 nm): Impair KC-dependent phagocytosis (platelet-depletion assay), increasing liver lipid accumulation (Oil-red-O, ORO staining). #Nanoplastics (NPs, 50 nm): Affect glucose metabolism and reach the brain, but don’t trigger neuroinflammation.

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Mass Lab @masslab.bsky.social · 18/03/2025

3/ 🔬 Using a chronic exposure model in mice, we found that liver-resident macrophages (Kupffer cells, KCs) are the primary site of MNP accumulation. Over time, this disrupts their function, leading to metabolic imbalances in the liver and beyond.

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Mass Lab @masslab.bsky.social · 11/02/2025

"Bacterial translocation promotes #trained #immunity" !!! 🤩 Check out our preview highlighting the beautiful peace @cp-immunity.bsky.social by the Sanches lab. With @mariafviola.bsky.social #macrophages #Mincle authors.elsevier.com/a/1kbBf3qNrU...

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Mass Lab @masslab.bsky.social · 12/01/2025

Only few more days left to apply! We have several #PhD #positions in the field of #immunology #development #cellbiology #macrophages! #FOR5775 is hiring!! Find details here: macrophagenetwork.com/news-2/ Pls repost👇 #immunosky

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Mass Lab @masslab.bsky.social · 27/11/2024

@haohuang0086.bsky.social presenting our maternal obesity @ #EMDS !! Check out also our poster about the role of microplastics in #Kupffer cells by @mariafviola.bsky.social

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