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Marta Moreno Gonzalez

@martamorgonz.bsky.social

17 followers 13 following 4 posts

PhD student @ Kind lab, Hubrecht Institute 🧬 Single-cell epigenetics & 💻 Bioinformatics

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Marta Moreno Gonzalez @martamorgonz.bsky.social · 30/12/2025

📄 The paper: academic.oup.com/nargab/artic... 💻 Software: github.com/KindLab/SCIBED

academic.oup.com

A computational framework to dissect imputation strategies for single-cell histone modification data

Abstract. Single-cell profiling of histone post-translational modifications (scHPTMs) offers a powerful lens for dissecting epigenetic regulation and cellu

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Marta Moreno Gonzalez @martamorgonz.bsky.social · 30/12/2025

3/ In this study, we introduce SCIBED, a computational framework that uses realistic simulations and tailored evaluation metrics to evaluate and compare these methods, helping researchers to make informed choices.

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Marta Moreno Gonzalez @martamorgonz.bsky.social · 30/12/2025

2/ ❓What is it about? Single-cell data is inherently noisy and incomplete. Although numerous algorithms exist to fill in missing data in single-cell gene expression, their performance on single-cell histone data has not been systematically explored yet.

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Marta Moreno Gonzalez @martamorgonz.bsky.social · 30/12/2025

1/ 🧬 Very excited to share our work on dissecting imputation strategies for single-cell histone modification data! academic.oup.com/nargab/artic... A huge thank you to @robinhweide.bsky.social, @jopkind.bsky.social and Jeroen de Ridder for their collaboration in this project!

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