Reposted by Mark WagnerRui Ponte Costa @somnirons.bsky.social · 01/10/2026Great summary of our paper with @mark-j-wagner.bsky.social 0145
Mark Wagner @mark-j-wagner.bsky.social · 17/09/2026Thank you! Yes, given the similarities to cortex, we think it’s a network thing, but definitely could local contributions too! 010
Mark Wagner @mark-j-wagner.bsky.social · 16/09/2026In this case, we think it could be solving the local credit assignment problem! 150
Mark Wagner @mark-j-wagner.bsky.social · 16/09/2026At reward, climbing fibers carried strong instructive signals - and optogenetic climbing fiber activation reinforced the pushing behavior. Congratulations to lead author Benjamin Filio and the rest of the team! The Wagner Lab is recruiting postdocs and graduate trainees: mark.wagner@nih.gov 140
Mark Wagner @mark-j-wagner.bsky.social · 16/09/2026Granule cells formed dense, temporally extended predictive signals that bridged the delay. Individual cells rescaled when reward timing changed and generalized between water and dopamine rewards. Inhibiting granule cell activity during the delay disrupted push-for-dopamine learning and execution. 130
Mark Wagner @mark-j-wagner.bsky.social · 16/09/2026Mice learned to push for self-stimulation rewards delivered after a delay while we imaged cerebellar granule cells and climbing fibers. The two populations carried strikingly different signals across the action-to-reward interval. 110
Mark Wagner @mark-j-wagner.bsky.social · 16/09/2026Granule cells predict future dopamine reward. Delayed climbing-fiber signals can reinforce the action that precedes it. Our paper, led by Benjamin Filio, is out today in Nature Neuroscience. www.nature.com/articles/s41... Public PDF: rdcu.be/RscCNeXvkXAa 35913
Reposted by Mark WagnerEarl K. Miller @earlkmiller.bsky.social · 30/08/2026The cortex and cerebellum split the labor: the cortex provides a stable, general-purpose movement blueprint, while the cerebellum reorients that same blueprint differently for each context Granule cells reorient cortical trajectories to separate contexts www.nature.com/articles/s41... #neurosciencenature.comGranule cells reorient cortical trajectories to separate contexts - NatureSimultaneous imaging of premotor cortex and cerebellar granule cells in mice learning two skills in parallel shows that trajectories generalize in cortex but coherently reorient apart in granule cells... 0488
Reposted by Mark WagnerRui Ponte Costa @somnirons.bsky.social · 27/08/2026How does the brain continually adapt? Fresh in @natureportfolio.nature.com our super exciting collaboration with @mark-j-wagner.bsky.social showing that the cerebellum contextualises cortical dynamics enable multi-task learning: www.nature.com/articles/s41...nature.comGranule cells reorient cortical trajectories to separate contexts - NatureSimultaneous imaging of premotor cortex and cerebellar granule cells in mice learning two skills in parallel shows that trajectories generalize in cortex but coherently reorient apart in granule cells... 19628
Mark Wagner @mark-j-wagner.bsky.social · 26/08/2026How the cerebellum separates related contexts—now out in Nature! Martha Garcia-Garcia led this tour de force, with theory from @somnirons.bsky.social & Michał Wójcik. Martha is on the faculty market, and I could not recommend her more highly. My lab is also recruiting! www.nature.com/articles/s41... 16121
Mark Wagner @mark-j-wagner.bsky.social · 06/03/2026Zero cerebellum is actually amazingly rare, and probably leads to lots of compensatory changes, but my read is it causes far too many problems to isolate something this specific... 020
Mark Wagner @mark-j-wagner.bsky.social · 06/03/2026Shout-out to Flash & Hogan :) - here we're imagining the manifold as a temporal scaffold that you can map onto different outputs... 100
Mark Wagner @mark-j-wagner.bsky.social · 05/03/2026The cortex generates invariant dynamic primitives; the cerebellum reconfigures them to drive distinct policies. Huge congrats to first author Martha Garcia-Garcia for leading this tour de force, and @somnirons.bsky.social & Michal Wojcik for a great collaboration! www.biorxiv.org/content/10.6...biorxiv.org 3153
Mark Wagner @mark-j-wagner.bsky.social · 05/03/2026We simultaneously imaged premotor cortical output (L5PT) and cerebellar granule cells during VR & reaching tasks. The cortex reused manifolds. But the cerebellum didn't shatter them—it reoriented them, rotating them apart while perfectly preserving their geometry! 🤯 231
Mark Wagner @mark-j-wagner.bsky.social · 05/03/2026The Problem: The cortex uses low-dimensional manifolds to generalize learning. But to prevent interference, circuits must separate overlapping contexts. Dogma says the cerebellum "shatters" inputs to orthogonalize...but that destroys the smooth geometry needed for continuous prediction and control. 130
Mark Wagner @mark-j-wagner.bsky.social · 05/03/2026How does the brain generalize past experiences without confusing memories? 🧠 Our lab's newest preprint reveals a fundamental division of labor between the cortex and cerebellum that solves this problem. (Check out the cortex-cerebellum video below! 👇) 🧵 16819
