iiinova — where your digital self keeps evolving

Mariel Kleer @marielkleer.bsky.social · 17/09/2026

So happy to have this story out! What started as a project about the protein products of a polycistronic mRNA ended up becoming a story about how RNA-mediated assembly of nuclear speckles promotes viral gene expression. What a ride, some very good days on the microscope!! 🔬 @corcoranlab.bsky.social

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Reposted by Mariel Kleer

Stern-Ginossar Lab @sginossarlab.bsky.social · 15/01/2026

Our new paper is out in Nature 🎉. We show that m1Ψ in mRNA vaccines doesn’t just quiet immunity, it also directly enhance translation by reshaping ribosome dynamics in a sequence-dependent way 🧬 Full paper : rdcu.be/eY5gx

rdcu.be

N1-Methylpseudouridine directly modulates translation dynamics

Nature - N1-Methylpseudouridine enhances the translation of synthetic mRNAs, independently of innate immunity.

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Reposted by Mariel Kleer

Craig McCormick @craigmccormick.bsky.social · 29/08/2025

A plea from a humble virologist. Worried about my team. Annoyed by interference from @dalhousie.bsky.social leadership. LOCKED OUT! @dalfaculty.bsky.social #KeepDalStrong

Sidewalk chalk message that says “Let me back in my lab”, as part of Dalhousie University faculty protest due to lockout.

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Reposted by Mariel Kleer

Corcoran Lab @corcoranlab.bsky.social · 27/02/2025

Our newest work reveals that SARS-CoV-2 evolved to produce a truncated version of its N protein to antagonize antiviral responses. This 'mini' N, called N*M210, sequesters dsRNA, blocks interferon activation, defeats RNaseL & disassembles stress granules and p-bodies. www.biorxiv.org/content/10.1...

biorxiv.org

A truncated SARS-CoV-2 nucleocapsid protein enhances virus fitness by evading antiviral responses

Viruses face a selective pressure to evade cellular antiviral responses to control the outcome of an infection. However, due to their limited genome size, viruses must adopt unique strategies to confr...

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