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Mark de Geus

@mardegeus.bsky.social

NWO Veni Fellow @TUDelft - (Dissociative) Bioorthogonal Chemistry | Bioconjugation | Antibody-Drug Conjugates (ADCs)

Mark de Geus @mardegeus.bsky.social · 10/06/2025

Excited to see this beautiful cover art by @barthvanrossum.bsky.social, which clearly illustrates our new bioconjugation chemistry for precise antibody modification in @jacs.acspublications.org! A big thank you to all co-authors @fmp-berlin.de & Tubulis GmbH and @humboldt-foundation.de for funding!

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Mark de Geus @mardegeus.bsky.social · 07/05/2025

Happy to share the publication of my postdoc research in the Hackenberger lab in @jacs.acspublications.org. Privileged to have worked alongside colleagues at @fmp-berlin.de and Tubulis GmbH. A big thank you to @humboldt-foundation.de for funding this exciting project!! pubs.acs.org/doi/10.1021/...

pubs.acs.org

Orthogonal Site-Specific Dual Bioconjugation of Aryl and Alkyl Thiols

We introduce aryl thiols as nucleophiles for site-specific protein and antibody bioconjugation, which allows the orthogonal labeling of native cysteines for double modification strategies. In a high-y...

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