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Reposted by Marton Czikkely

Csaba Pal Laboratory @csabapallab.bsky.social · 24/02/2025

🚨 Our latest research in @naturecomms.bsky.social shows a promising strategy for less resistance-prone #antibiotics. For details, see the thread below and read the paper “Exploring the principles behind antibiotics with limited resistance” here: #MEvoSky www.nature.com/articles/s41...

nature.com

Exploring the principles behind antibiotics with limited resistance - Nature Communications

This study shows that only those dual-targeting antibiotics limit resistance in Gram-negative pathogens that also target the membrane of the bacteria. This mechanism provides a basis for designing fut...

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Reposted by Marton Czikkely

Csaba Pal Laboratory @csabapallab.bsky.social · 13/01/2025

For a similar study on Gram-positive bacteria, check out our previous thread: bsky.app/profile/csab...

041

Reposted by Marton Czikkely

Nature Microbiology @natmicrobiol.nature.com · 13/01/2025

💊🦠OUT NOW - comprehensive analysis of the propensity of ESKAPE pathogens to evolve resistance to new and in development antibiotics by Csaba Pal, Balint Kintses, Balazs Papp and colleagues. Dive in here... www.nature.com/articles/s41...

nature.com

ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro - Nature Microbiology

An extensive experimental analysis of resistance to antibiotics in development or introduced post-2017 in ESKAPE bacteria reveals the dynamics of resistance acquisition, mutational targets and the pre...

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