Novel mRNA treatment developed at UMass Chan Medical School eliminates pancreatic cancer tumors in 50 percent of treated mice.

Pancreatic ductal adenocarcinoma (PDAC) displays dismal immunotherapy outcomes in part through a lack of cytokine and antigen signals needed for anti-tumor immunity. The authors here develop a cocktai...

UMMS is hiring a Post Doc - Open Rank - Ruscetti Lab in Worcester, Massachusetts. Review all of the job details and apply today!

AbstractPatients with castration-resistant prostate cancer (CRPC) are generally unresponsive to tumor-targeted treatments and immunotherapies. Genetic alterations acquired during the evolution of CRPC...

AbstractPatients with castration-resistant prostate cancer (CRPC) are generally unresponsive to tumor-targeted treatments and immunotherapies. Genetic alterations acquired during the evolution of CRPC...

Abstract. Cellular senescence is a well-established tumor-suppressive cell cycle arrest program. However, chronic inflammation through the senescence-associated secretory phenotype (SASP) can alternat...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Nature - Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining...

Researchers at academic institutions nationwide say that U.S. science is being dismantled.

A dual recombinase-mediated genetic system for cell-type-specific lineage tracing, ablation, and gene manipulation of senescent cells reveals distinct roles of senescence across cell types.

Understanding the impact of senescence on disease is limited by the lack of tools to lineage label senescent cells. In a recent Cell issue, Zhao et al. create mouse models to genetically manipulate and trace p16+ cells, identifying contrasting roles for senescent macrophages and endothelial cells (ECs) in liver fibrosis.