iiinova — where your digital self keeps evolving

MaraverLab @maraverlab.bsky.social · 03/04/2025

This work was possible thanks to a fantastic group of colleagues from @ircm-mtp.bsky.social @ICM_Montpellier @umontpellier.bsky.social @goteborgsuni @cniostopcancer.bsky.social @CIMA_unav @H12Octubre @nyulangone Thanks a lot to all our great collaborators!! Together we are stronger!!!

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MaraverLab @maraverlab.bsky.social · 03/04/2025

This work was possible thanks to a fantastic and complementary group of colleagues from @IRCM_MTP @ICM_Montpellier @umontpellier @goteborgsuni @CNIOStopCancer @CIMA_unav @H12Octubre @nyulangone Thanks a lot to all our great collaborators!! Together we are stronger!!!

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MaraverLab @maraverlab.bsky.social · 03/04/2025

As you know, ferroptosis inhibitors are still far from being used in the clinic, but our findings provide a new way to sensitize cells against them which could facilitate their clinical translation, at least to treat the leading cause of death by cancer in the world, i.e., lung.

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MaraverLab @maraverlab.bsky.social · 03/04/2025

4. We further dissect the mechanism and uncovered that FMO4 binds MAT2A, leading to the stabilization of the MAT2A-MAT2B complex in order to promote the generation of cysteine that in turn regenerates reduced glutathione to allow GPX4-driven protection against ferroptosis.

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MaraverLab @maraverlab.bsky.social · 03/04/2025

2. We demonstrate that FMO is critically required for KRAS-driven lung cancer generation and maintenance in mice in vivo. 3. We found that FMO4 deletion in lung cancer sensitizes cells against ferroptosis both in vitro and in vivo, revealing FMO4 as an interesting target in lung cancer.

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MaraverLab @maraverlab.bsky.social · 03/04/2025

1. We first found that flavin containing monooxygenase 4 (FMO4) is highly expressed in lung tumors and very low expressed in healthy lung in mouse and lung cancer patients where its expression negatively correlates with patients’ survival.

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MaraverLab @maraverlab.bsky.social · 03/04/2025

Thrilled to present our study aiming to identify new vulnerabilities in lung cancer: www.biorxiv.org/content/10.1... Joining forces from mouse genetics, thoracic oncology, metabolism, and AlphaFold fields we dissected the role of a largely unknown but essential protein in cancer, FMO4.🧵

biorxiv.org

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Reposted by MaraverLab

Herranz Lab @herranzlab.bsky.social · 21/01/2025

Happy to share our latest findings @bloodneoplasia.bsky.social uncovering an ACLY-MYC feedforward loop in T-ALL, led by @dasilva-diz.bsky.social doi.org/10.1016/j.bn...

doi.org

Redirecting

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MaraverLab @maraverlab.bsky.social · 20/11/2024

it is funny because is true 😂😂

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MaraverLab @maraverlab.bsky.social · 20/11/2024

On my way to the 20th annual meeting Cancéropôle Grand Sud-Ouest to enjoy 2 days fully charged of super cool science!! Like in previous editions, we have fantastic national and international speakers and our lab will present several cool studies so stay tuned 😀

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Reposted by MaraverLab

Alexandre Djiane @adjiane.bsky.social · 18/11/2024

We are looking for our future colleagues. IRCM (www.ircm.fr) host labs studying cancer biology from basic to translational research. Montpellier has a thriving and very dynamic scientific life. Please forward to potential candidates.

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Reposted by MaraverLab

Lung Cancer Research Foundation @lcrf.org · 12/11/2024

November is Lung Cancer Awareness Month. One simple truth: if you have lungs, you can get lung cancer. In fact, 1 in 16 people will receive a #LungCancer diagnosis in their lifetime. Spread the word! Visit LCRF.org/LCAM to learn how. #LCAM2024

Graphic titled "If you have lungs, you can get lung cancer."

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MaraverLab @maraverlab.bsky.social · 15/11/2024

I cannot think a better way to start our communication in bsky than promoting the Lung Cancer Awareness Month (LCAM) with our commitment to tackle this deadly disease. And to remind you: "if you have lungs, you can have lung cancer" @lungcancerresearch.bsky.social and many more not yet @bsky.app

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