Reposted by @mansoorlabohsu.bsky.socialcryoEM papers @cryoempapers.bsky.social · 12/04/2026A brain-penetrant P2X7R antagonist mitigates Alzheimer’s disease pathology www.biorxiv.org/content/10.64898/2026.04.06.716621v1 #cryoem 022
mansoorlabohsu.bsky.social @mansoorlabohsu.bsky.social · 09/04/2026Excited to share our latest preprint on bioRxiv! www.biorxiv.org/content/10.6... An international, multidisciplinary collaboration spanning structural biology, chemical biology, neuroscience, and translational medicine. Grateful to everyone involved in making this work possible!biorxiv.org 041
mansoorlabohsu.bsky.social @mansoorlabohsu.bsky.social · 08/10/2025link.growkudos.com/1eub610y1hclink.growkudos.comMolecular Structures of the Hearing Loss Associated Human P2X2 ReceptorATP is best known as the “fuel of the cell,” providing energy for nearly every biological process. But when ATP is released from cells, it takes on a very different role — acting as a danger signal th... 021
Reposted by @mansoorlabohsu.bsky.socialcryoEM papers @cryoempapers.bsky.social · 16/09/2025A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor pubmed.ncbi.nlm.nih.gov/40954149/ #cryoEM 022
mansoorlabohsu.bsky.social @mansoorlabohsu.bsky.social · 15/09/2025Another manuscript from our group this week with the first structures of the human P2X7 receptor facilitating development of a novel scaffold for P2X7R antagonists: urldefense.com/v3/__https:/... @pacificnwcryoem.bsky.social @ohsunews.bsky.social @ohsubrain.bsky.social 194
Reposted by @mansoorlabohsu.bsky.socialcryoEM papers @cryoempapers.bsky.social · 13/09/2025Subtype-specific structural features of the hearing loss-associated human P2X2 receptor pubmed.ncbi.nlm.nih.gov/40938707/ #cryoEM 021
mansoorlabohsu.bsky.social @mansoorlabohsu.bsky.social · 14/09/2025Our latest work on the human P2X2 receptor. We identified an alternate desensitized state conformation that provides insight into how ATP enters and/or leaves the pocket. www.pnas.org/doi/10.1073/... @pacificnwcryoem.bsky.social @ohsunews.bsky.social @ohsubrain.bsky.social 071
Reposted by @mansoorlabohsu.bsky.socialOHSU Surgical Data and Decision Sciences Lab @ohsusurgdata.bsky.social · 25/04/2025A true Physician-Scientist and @OHSUSOM #MDPhD alum, Dr. Steve Mansoor, sharing details about how his lab uses #DrugDesign principles to fit the ligand into the target receptor like a jigsaw piece. 🧩Thank you for your presentation Dr. Mansoor! @OHSUNews @OHSUCardio @OHSUSOM 153
Reposted by @mansoorlabohsu.bsky.socialmansoor-steven.bsky.social @mansoor-steven.bsky.social · 26/04/2025The KCVI research retreat was a great success this year. Very happy to participate. Looking forward to making this an annual event! 153
Reposted by @mansoorlabohsu.bsky.socialmansoor-steven.bsky.social @mansoor-steven.bsky.social · 30/03/2025Adam Oken from our lab gave a great presentation summarizing some of the work we have been doing. If you are interested, please watch a recording of his seminar, linked here: youtu.be/IdcoLJc7X8Myoutu.beMarch 27, 2025: Adam Oken, Oregon Health and Sciences UniversityYouTube video by CryoEM Service Centers 021
Reposted by @mansoorlabohsu.bsky.socialmansoor-steven.bsky.social @mansoor-steven.bsky.social · 02/03/2025A paper from our group published a couple of months ago. 021
Reposted by @mansoorlabohsu.bsky.socialmansoor-steven.bsky.social @mansoor-steven.bsky.social · 26/02/2025I am fortunate to have such a fantastic collaboration with amazing scientists from around the world. 021
