Reposted by @mansoor-steven.bsky.socialcryoEM papers @cryoempapers.bsky.social · 12/04/2026A brain-penetrant P2X7R antagonist mitigates Alzheimer’s disease pathology www.biorxiv.org/content/10.64898/2026.04.06.716621v1 #cryoem 022
mansoor-steven.bsky.social @mansoor-steven.bsky.social · 09/04/2026Excited to see this work out as a preprint! Proud to be part of this incredible international, multidisciplinary collaboration spanning structural biology, chemical biology, neuroscience, and translational medicine. This journey started ~7 years ago, and it’s been amazing! 141
Reposted by @mansoor-steven.bsky.socialmansoorlabohsu.bsky.social @mansoorlabohsu.bsky.social · 08/10/2025link.growkudos.com/1eub610y1hclink.growkudos.comMolecular Structures of the Hearing Loss Associated Human P2X2 ReceptorATP is best known as the “fuel of the cell,” providing energy for nearly every biological process. But when ATP is released from cells, it takes on a very different role — acting as a danger signal th... 021
Reposted by @mansoor-steven.bsky.socialcryoEM papers @cryoempapers.bsky.social · 16/09/2025A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor pubmed.ncbi.nlm.nih.gov/40954149/ #cryoEM 022
Reposted by @mansoor-steven.bsky.socialmansoorlabohsu.bsky.social @mansoorlabohsu.bsky.social · 15/09/2025Another manuscript from our group this week with the first structures of the human P2X7 receptor facilitating development of a novel scaffold for P2X7R antagonists: urldefense.com/v3/__https:/... @pacificnwcryoem.bsky.social @ohsunews.bsky.social @ohsubrain.bsky.social 194
mansoor-steven.bsky.social @mansoor-steven.bsky.social · 14/09/2025A fantastic collaboration with Dr. Christa Müller from the University of Bonn. Congratulations to graduate students Franka Westermann and Adam Oken for their efforts on this manuscript. 020
mansoor-steven.bsky.social @mansoor-steven.bsky.social · 14/09/2025A fantastic collaboration with Dr. Christa Müller from the University of Bonn. Congratulations to graduate students Franka Westermann and Adam Oken for their efforts on this manuscript. 000
Reposted by @mansoor-steven.bsky.socialVollum Institute @volluminstitute.bsky.social · 15/08/2025@volluminstitute.bsky.social neuroscientist Dr. Eric Gouaux has earned a rare distinction as a two-time recipient of the Javits Neuroscience Investigator Award from the National Institute of Neurological Disorders and Stroke! Read the full article: bit.ly/4b9gOw9 021
mansoor-steven.bsky.social @mansoor-steven.bsky.social · 26/04/2025The KCVI research retreat was a great success this year. Very happy to participate. Looking forward to making this an annual event! 153
mansoor-steven.bsky.social @mansoor-steven.bsky.social · 30/03/2025Adam Oken from our lab gave a great presentation summarizing some of the work we have been doing. If you are interested, please watch a recording of his seminar, linked here: youtu.be/IdcoLJc7X8Myoutu.beMarch 27, 2025: Adam Oken, Oregon Health and Sciences UniversityYouTube video by CryoEM Service Centers 021
mansoor-steven.bsky.social @mansoor-steven.bsky.social · 02/03/2025A paper from our group published a couple of months ago. 021
mansoor-steven.bsky.social @mansoor-steven.bsky.social · 26/02/2025I am fortunate to have such a fantastic collaboration with amazing scientists from around the world. 021
